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Patent code US8530652

Compile Data Set for Download or QSAR
Found 86 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101546
PNG
(US8530494, 211 | US8530652, 125 | US8530652, 73)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C25H29N7O2S/c1-15-26-18-11-12-35-20(18)23(27-15)28-22-17-13-32(25(2,3)21(17)29-30-22)24(33)34-19(14-31(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H2,26,27,28,29,30)/t19-/m1/s1
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 1.60n/an/an/a<3.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101542
PNG
(US8530494, 207 | US8530652, 121 | US8530652, 69)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3nc(C)nc4sccc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C25H29N7O2S/c1-15-26-21(17-11-12-35-23(17)27-15)28-22-18-13-32(25(2,3)20(18)29-30-22)24(33)34-19(14-31(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H2,26,27,28,29,30)/t19-/m1/s1
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 1.90n/an/an/a 3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101479
PNG
(US8524710, 56 | US8530652, 50 | US8530652, 6)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(Cl)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C24H27ClN8OS/c1-24(2)19-15(20(31-30-19)28-21-18-16(10-11-35-18)26-22(25)29-21)12-33(24)23(34)27-17(13-32(3)4)14-8-6-5-7-9-14/h5-11,17H,12-13H2,1-4H3,(H,27,34)(H2,26,28,29,30,31)/t17-/m1/s1
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 2.80n/an/an/a 0.940n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101537
PNG
(US8530494, 204 | US8530652, 115 | US8530652, 64)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(nc4ccccc34)C#N)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C27H29N9O/c1-27(2)23-19(15-36(27)26(37)30-21(16-35(3)4)17-10-6-5-7-11-17)25(34-33-23)32-24-18-12-8-9-13-20(18)29-22(14-28)31-24/h5-13,21H,15-16H2,1-4H3,(H,30,37)(H2,29,31,32,33,34)/t21-/m1/s1
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 3n/an/an/a<3.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM4838
PNG
(US8524710, 83 | US8530494, 13 | US8530652, 52)
Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2sccc2n1 |r|
Show InChI InChI=1S/C24H25N7OS/c1-13-25-17-9-10-33-19(17)22(26-13)28-21-16-12-31(24(2,3)20(16)29-30-21)23(32)27-18-11-15(18)14-7-5-4-6-8-14/h4-10,15,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t15-,18+/m0/s1
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 3.5n/an/an/a 19n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM4838
PNG
(US8524710, 83 | US8530494, 13 | US8530652, 52)
Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2sccc2n1 |r|
Show InChI InChI=1S/C24H25N7OS/c1-13-25-17-9-10-33-19(17)22(26-13)28-21-16-12-31(24(2,3)20(16)29-30-21)23(32)27-18-11-15(18)14-7-5-4-6-8-14/h4-10,15,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t15-,18+/m0/s1
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 3.5n/an/an/a 19n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101547
PNG
(US8530494, 212 | US8530652, 126 | US8530652, 74)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3nc(nc4ccccc34)C#N)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C27H28N8O2/c1-27(2)23-19(15-35(27)26(36)37-21(16-34(3)4)17-10-6-5-7-11-17)25(33-32-23)31-24-18-12-8-9-13-20(18)29-22(14-28)30-24/h5-13,21H,15-16H2,1-4H3,(H2,29,30,31,32,33)/t21-/m1/s1
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 3.60n/an/an/a<3.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101544
PNG
(US8530494, 105 | US8530652, 123 | US8530652, 71)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ncnc4sc(C)cc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C25H29N7O2S/c1-15-11-17-21(26-14-27-23(17)35-15)28-22-18-12-32(25(2,3)20(18)29-30-22)24(33)34-19(13-31(4)5)16-9-7-6-8-10-16/h6-11,14,19H,12-13H2,1-5H3,(H2,26,27,28,29,30)/t19-/m1/s1
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 5.20n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101548
PNG
(US8530494, 108 | US8530652, 127 | US8530652, 75)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ncnc4sccc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C24H27N7O2S/c1-24(2)19-17(21(29-28-19)27-20-16-10-11-34-22(16)26-14-25-20)12-31(24)23(32)33-18(13-30(3)4)15-8-6-5-7-9-15/h5-11,14,18H,12-13H2,1-4H3,(H2,25,26,27,28,29)/t18-/m1/s1
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 5.20n/an/an/a<3.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101541
PNG
(US8530494, 104 | US8530652, 120 | US8530652, 68)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ncnc4ccsc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C24H27N7O2S/c1-24(2)20-16(21(29-28-20)27-22-19-17(10-11-34-19)25-14-26-22)12-31(24)23(32)33-18(13-30(3)4)15-8-6-5-7-9-15/h5-11,14,18H,12-13H2,1-4H3,(H2,25,26,27,28,29)/t18-/m1/s1
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 6.70n/an/an/a 20n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101504
PNG
(US8524699, 91 | US8524710, 82 | US8530652, 31)
Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2ccsc2n1 |r|
Show InChI InChI=1S/C24H25N7OS/c1-13-25-20(15-9-10-33-22(15)26-13)28-21-17-12-31(24(2,3)19(17)29-30-21)23(32)27-18-11-16(18)14-7-5-4-6-8-14/h4-10,16,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t16-,18+/m0/s1
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 7.20n/an/an/a 21n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101549
PNG
(US8530494, 109 | US8530652, 128 | US8530652, 76)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ccnc(n3)C(F)(F)F)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C23H26F3N7O2/c1-22(2)18-15(19(31-30-18)28-17-10-11-27-20(29-17)23(24,25)26)12-33(22)21(34)35-16(13-32(3)4)14-8-6-5-7-9-14/h5-11,16H,12-13H2,1-4H3,(H2,27,28,29,30,31)/t16-/m1/s1
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 8.30n/an/an/a<3.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101543
PNG
(US8530494, 206 | US8530652, 122 | US8530652, 70)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ccnc(n3)C#N)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C23H26N8O2/c1-23(2)20-16(21(29-28-20)27-18-10-11-25-19(12-24)26-18)13-31(23)22(32)33-17(14-30(3)4)15-8-6-5-7-9-15/h5-11,17H,13-14H2,1-4H3,(H2,25,26,27,28,29)/t17-/m1/s1
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 8.80n/an/an/a 1.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101476
PNG
(US8524710, 53 | US8530652, 3 | US8530652, 47)
Show SMILES CN1CCN([C@@H](Cc2ccccc2)C1)C(=O)N1Cc2c(Nc3nc(Cl)nc4ccsc34)[nH]nc2C1(C)C |r|
Show InChI InChI=1S/C26H29ClN8OS/c1-26(2)21-18(22(32-31-21)29-23-20-19(9-12-37-20)28-24(27)30-23)15-35(26)25(36)34-11-10-33(3)14-17(34)13-16-7-5-4-6-8-16/h4-9,12,17H,10-11,13-15H2,1-3H3,(H2,28,29,30,31,32)/t17-/m0/s1
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 11n/an/an/a 16n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101475
PNG
(US8524710, 52 | US8530652, 2 | US8530652, 46)
Show SMILES CC1(C)N(Cc2c(Nc3nc(Cl)nc4ccsc34)[nH]nc12)C(=O)NC1CC1c1ccccc1
Show InChI InChI=1S/C23H22ClN7OS/c1-23(2)18-14(11-31(23)22(32)26-16-10-13(16)12-6-4-3-5-7-12)19(30-29-18)27-20-17-15(8-9-33-17)25-21(24)28-20/h3-9,13,16H,10-11H2,1-2H3,(H,26,32)(H2,25,27,28,29,30)
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 14n/an/an/a 36n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101530
PNG
(US8530494, 29 | US8530494, 7 | US8530652, 57)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4n(C)cnc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C24H30N10O/c1-24(2)19-16(20(31-30-19)29-21-18-22(26-13-25-21)33(5)14-27-18)11-34(24)23(35)28-17(12-32(3)4)15-9-7-6-8-10-15/h6-10,13-14,17H,11-12H2,1-5H3,(H,28,35)(H2,25,26,29,30,31)/t17-/m1/s1
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 14n/an/an/a 2.5n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101535
PNG
(US8530494, 104 | US8530652, 113 | US8530652, 62)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4sc(C)cc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C25H30N8OS/c1-15-11-17-21(26-14-27-23(17)35-15)29-22-18-12-33(25(2,3)20(18)30-31-22)24(34)28-19(13-32(4)5)16-9-7-6-8-10-16/h6-11,14,19H,12-13H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1
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 15n/an/an/a 15n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101545
PNG
(US8530494, 107 | US8530652, 124 | US8530652, 72)
Show SMILES CCOc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)O[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 |r|
Show InChI InChI=1S/C24H30FN7O3/c1-6-34-22-26-12-17(25)21(28-22)27-20-16-13-32(24(2,3)19(16)29-30-20)23(33)35-18(14-31(4)5)15-10-8-7-9-11-15/h7-12,18H,6,13-14H2,1-5H3,(H2,26,27,28,29,30)/t18-/m1/s1
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 16n/an/an/a 4.40n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101515
PNG
(US8524699, 26 | US8530652, 42 | US8530670, 31)
Show SMILES CC1(C)N(Cc2c(Nc3ncnc4sccc34)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H23N7OS/c1-23(2)18-16(20(29-28-18)27-19-14-8-9-32-21(14)25-12-24-19)11-30(23)22(31)26-17-10-15(17)13-6-4-3-5-7-13/h3-9,12,15,17H,10-11H2,1-2H3,(H,26,31)(H2,24,25,27,28,29)/t15-,17+/m0/s1
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 16n/an/an/a 340n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101513
PNG
(US8524699, 18 | US8530652, 40 | US8530652, 85)
Show SMILES CC1(C)N(Cc2c(Nc3nc(nc4ccccc34)C#N)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C26H24N8O/c1-26(2)22-18(14-34(26)25(35)29-20-12-17(20)15-8-4-3-5-9-15)24(33-32-22)31-23-16-10-6-7-11-19(16)28-21(13-27)30-23/h3-11,17,20H,12,14H2,1-2H3,(H,29,35)(H2,28,30,31,32,33)/t17-,20+/m0/s1
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 18n/an/an/a 98n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101524
PNG
(US8530652, 51 | US8530652, 96)
Show SMILES CC1(C)N(Cc2c(Nc3ncnc4ccsc34)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H23N7OS/c1-23(2)19-15(20(29-28-19)27-21-18-16(8-9-32-18)24-12-25-21)11-30(23)22(31)26-17-10-14(17)13-6-4-3-5-7-13/h3-9,12,14,17H,10-11H2,1-2H3,(H,26,31)(H2,24,25,27,28,29)/t14-,17+/m0/s1
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 18n/an/an/a 31n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101504
PNG
(US8524699, 91 | US8524710, 82 | US8530652, 31)
Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2ccsc2n1 |r|
Show InChI InChI=1S/C24H25N7OS/c1-13-25-20(15-9-10-33-22(15)26-13)28-21-17-12-31(24(2,3)19(17)29-30-21)23(32)27-18-11-16(18)14-7-5-4-6-8-14/h4-10,16,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t16-,18+/m0/s1
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 20n/an/an/a 103n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101536
PNG
(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1
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 20n/an/an/a<3.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101507
PNG
(US8524710, 86 | US8530652, 34 | US8530652, 79)
Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)cc(n1)N1CCOCC1 |r|
Show InChI InChI=1S/C26H32N8O2/c1-16-27-21(14-22(28-16)33-9-11-36-12-10-33)30-24-19-15-34(26(2,3)23(19)31-32-24)25(35)29-20-13-18(20)17-7-5-4-6-8-17/h4-8,14,18,20H,9-13,15H2,1-3H3,(H,29,35)(H2,27,28,30,31,32)/t18-,20+/m0/s1
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 21n/an/an/a 778n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101534
PNG
(US8530494, 202 | US8530652, 112 | US8530652, 61)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4sccc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C24H28N8OS/c1-24(2)19-17(21(30-29-19)28-20-16-10-11-34-22(16)26-14-25-20)12-32(24)23(33)27-18(13-31(3)4)15-8-6-5-7-9-15/h5-11,14,18H,12-13H2,1-4H3,(H,27,33)(H2,25,26,28,29,30)/t18-/m1/s1
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 22n/an/an/a 19n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101514
PNG
(US8524699, 22 | US8530652, 41 | US8530652, 86)
Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)C3(C)C)c2sccc2n1 |r|
Show InChI InChI=1S/C24H25N7OS/c1-13-25-17-9-10-33-19(17)22(26-13)28-21-16-12-31(24(2,3)20(16)29-30-21)23(32)27-18-11-15(18)14-7-5-4-6-8-14/h4-10,15,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t15-,18+/m1/s1
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 24n/an/an/a 147n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101518
PNG
(US8524699, 46 | US8530652, 45 | US8530652, 90)
Show SMILES CC1(C)N(Cc2c(Nc3nc(nc4ccsc34)C(F)(F)F)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C24H22F3N7OS/c1-23(2)18-14(11-34(23)22(35)29-16-10-13(16)12-6-4-3-5-7-12)19(33-32-18)30-20-17-15(8-9-36-17)28-21(31-20)24(25,26)27/h3-9,13,16H,10-11H2,1-2H3,(H,29,35)(H2,28,30,31,32,33)/t13-,16+/m0/s1
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 25n/an/an/a 32n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101639
PNG
(US8530652, 84)
Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@H]2c2ccccc2)C3(C)C)c2ccccc2n1 |r|
Show InChI InChI=1S/C26H27N7O/c1-15-27-20-12-8-7-11-17(20)23(28-15)30-24-19-14-33(26(2,3)22(19)31-32-24)25(34)29-21-13-18(21)16-9-5-4-6-10-16/h4-12,18,21H,13-14H2,1-3H3,(H,29,34)(H2,27,28,30,31,32)/t18-,21?/m0/s1
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 34n/an/an/a 455n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101485
PNG
(US8524710, 62 | US8530652, 12 | US8530652, 56)
Show SMILES CC1(C)N(Cc2c(Nc3nc(Cl)nc4ccccc34)[nH]nc12)C(=O)NC1CC1c1ccccc1
Show InChI InChI=1S/C25H24ClN7O/c1-25(2)20-17(13-33(25)24(34)28-19-12-16(19)14-8-4-3-5-9-14)22(32-31-20)29-21-15-10-6-7-11-18(15)27-23(26)30-21/h3-11,16,19H,12-13H2,1-2H3,(H,28,34)(H2,27,29,30,31,32)
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 38n/an/an/a 78n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101552
PNG
(US8530494, 214 | US8530652, 131 | US8530652, 79)
Show SMILES COc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)O[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 |r|
Show InChI InChI=1S/C23H28FN7O3/c1-23(2)18-15(19(29-28-18)26-20-16(24)11-25-21(27-20)33-5)12-31(23)22(32)34-17(13-30(3)4)14-9-7-6-8-10-14/h6-11,17H,12-13H2,1-5H3,(H2,25,26,27,28,29)/t17-/m1/s1
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 39n/an/an/a>3.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101533
PNG
(US8530494, 103 | US8530652, 111 | US8530652, 60)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ccnc(n3)C#N)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C23H27N9O/c1-23(2)20-16(21(30-29-20)28-18-10-11-25-19(12-24)27-18)13-32(23)22(33)26-17(14-31(3)4)15-8-6-5-7-9-15/h5-11,17H,13-14H2,1-4H3,(H,26,33)(H2,25,27,28,29,30)/t17-/m1/s1
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 40n/an/an/a<3.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101556
PNG
(US8530652, 1)
Show SMILES CC1(C)N(Cc2c(Nc3ncnc4ccsc34)[nH]nc12)C(=O)N[C@H]1CC1c1ccccc1 |r|
Show InChI InChI=1S/C23H23N7OS/c1-23(2)19-15(20(29-28-19)27-21-18-16(8-9-32-18)24-12-25-21)11-30(23)22(31)26-17-10-14(17)13-6-4-3-5-7-13/h3-9,12,14,17H,10-11H2,1-2H3,(H,26,31)(H2,24,25,27,28,29)/t14?,17-/m0/s1
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 41n/an/an/a>2.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101506
PNG
(US8524710, 85 | US8530652, 33 | US8530652, 78)
Show SMILES CC1(C)N(Cc2c(Nc3ccnc(n3)C#N)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C22H22N8O/c1-22(2)19-15(20(29-28-19)27-17-8-9-24-18(11-23)26-17)12-30(22)21(31)25-16-10-14(16)13-6-4-3-5-7-13/h3-9,14,16H,10,12H2,1-2H3,(H,25,31)(H2,24,26,27,28,29)/t14-,16+/m0/s1
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 47n/an/an/a 618n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101641
PNG
(US8530652, 86)
Show SMILES CC1(C)N(Cc2c(Nc3nc(nc4ccccc34)C3CC3)[nH]nc12)C(=O)NC1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C28H29N7O/c1-28(2)23-20(15-35(28)27(36)30-22-14-19(22)16-8-4-3-5-9-16)26(34-33-23)32-25-18-10-6-7-11-21(18)29-24(31-25)17-12-13-17/h3-11,17,19,22H,12-15H2,1-2H3,(H,30,36)(H2,29,31,32,33,34)/t19-,22?/m0/s1
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 55n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101638
PNG
(US8530652, 83)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4ccoc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C24H28N8O2/c1-24(2)20-16(21(30-29-20)28-22-19-17(10-11-34-19)25-14-26-22)12-32(24)23(33)27-18(13-31(3)4)15-8-6-5-7-9-15/h5-11,14,18H,12-13H2,1-4H3,(H,27,33)(H2,25,26,28,29,30)/t18-/m1/s1
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 58n/an/an/a 84n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101526
PNG
(US8530494, 11 | US8530652, 53 | US8530652, 98)
Show SMILES CC1(C)N(Cc2c(Nc3ncnc4ccoc34)n[nH]c12)C(=O)N[C@H]1C[C@@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H23N7O2/c1-23(2)19-15(20(29-28-19)27-21-18-16(8-9-32-18)24-12-25-21)11-30(23)22(31)26-17-10-14(17)13-6-4-3-5-7-13/h3-9,12,14,17H,10-11H2,1-2H3,(H,26,31)(H2,24,25,27,28,29)/t14-,17+/m1/s1
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 67n/an/an/a 1.75E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101489
PNG
(US8524710, 67 | US8530652, 16 | US8530652, 60)
Show SMILES COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(n1)N1CCC[C@H]1CO |r|
Show InChI InChI=1S/C26H33N9O3/c1-26(2)20-18(13-35(26)25(37)27-19-12-17(19)15-8-5-4-6-9-15)21(33-32-20)28-22-29-23(31-24(30-22)38-3)34-11-7-10-16(34)14-36/h4-6,8-9,16-17,19,36H,7,10-14H2,1-3H3,(H,27,37)(H2,28,29,30,31,32,33)/t16-,17+,19?/m0/s1
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 76n/an/an/a 1.27E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101503
PNG
(US8524710, 81 | US8530652, 30 | US8530652, 74)
Show SMILES CC1(C)N(Cc2c(Nc3ccnc(n3)C(F)(F)F)[nH]nc12)C(=O)NC1C[C@@H]1c1ccccc1 |r|
Show InChI InChI=1S/C22H22F3N7O/c1-21(2)17-14(18(31-30-17)28-16-8-9-26-19(29-16)22(23,24)25)11-32(21)20(33)27-15-10-13(15)12-6-4-3-5-7-12/h3-9,13,15H,10-11H2,1-2H3,(H,27,33)(H2,26,28,29,30,31)/t13-,15?/m1/s1
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 80n/an/an/a 968n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101554
PNG
(US8530494, 210 | US8530652, 134 | US8530652, 81)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(Nc3ncnc4c(C)csc34)[nH]nc2C1(C)C |r|
Show InChI InChI=1S/C23H30N8OS/c1-13-11-33-18-17(13)24-12-25-21(18)26-20-16-10-31(23(3,4)19(16)27-28-20)22(32)30-9-15-6-5-7-29(15)8-14(30)2/h11-12,14-15H,5-10H2,1-4H3,(H2,24,25,26,27,28)/t14-,15-/m0/s1
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 84n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101480
PNG
(US8524710, 57 | US8530652, 51 | US8530652, 7)
Show SMILES CCCOc1nc(Cl)nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)n1
Show InChI InChI=1S/C23H27ClN8O2/c1-4-10-34-21-28-19(24)27-20(29-21)26-18-15-12-32(23(2,3)17(15)30-31-18)22(33)25-16-11-14(16)13-8-6-5-7-9-13/h5-9,14,16H,4,10-12H2,1-3H3,(H,25,33)(H2,26,27,28,29,30,31)
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 87n/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101488
PNG
(US8524710, 66 | US8530652, 15 | US8530652, 59)
Show SMILES CN(C)c1nc(Cl)nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)n1
Show InChI InChI=1S/C22H26ClN9O/c1-22(2)16-14(17(30-29-16)25-19-26-18(23)27-20(28-19)31(3)4)11-32(22)21(33)24-15-10-13(15)12-8-6-5-7-9-12/h5-9,13,15H,10-11H2,1-4H3,(H,24,33)(H2,25,26,27,28,29,30)
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 90n/an/an/a 500n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM4827
PNG
(US8530652, 20)
Show SMILES COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(n1)N1CCCC1C#N
Show InChI InChI=1S/C26H30N10O2/c1-26(2)20-18(14-36(26)25(37)28-19-12-17(19)15-8-5-4-6-9-15)21(34-33-20)29-22-30-23(32-24(31-22)38-3)35-11-7-10-16(35)13-27/h4-6,8-9,16-17,19H,7,10-12,14H2,1-3H3,(H,28,37)(H2,29,30,31,32,33,34)
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 90n/an/an/a 1.20E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101550
PNG
(US8530494, 110 | US8530652, 129 | US8530652, 77)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ncnc(C)c3F)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C23H28FN7O2/c1-14-18(24)21(26-13-25-14)27-20-16-11-31(23(2,3)19(16)28-29-20)22(32)33-17(12-30(4)5)15-9-7-6-8-10-15/h6-10,13,17H,11-12H2,1-5H3,(H2,25,26,27,28,29)/t17-/m1/s1
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 93n/an/an/a 69n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101515
PNG
(US8524699, 26 | US8530652, 42 | US8530670, 31)
Show SMILES CC1(C)N(Cc2c(Nc3ncnc4sccc34)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H23N7OS/c1-23(2)18-16(20(29-28-18)27-19-14-8-9-32-21(14)25-12-24-19)11-30(23)22(31)26-17-10-15(17)13-6-4-3-5-7-13/h3-9,12,15,17H,10-11H2,1-2H3,(H,26,31)(H2,24,25,27,28,29)/t15-,17+/m0/s1
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 94n/an/an/a 610n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101511
PNG
(US8524699, 7 | US8530652, 38 | US8530652, 83)
Show SMILES CN(C)c1cc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)nc(C)n1 |r|
Show InChI InChI=1S/C24H30N8O/c1-14-25-19(12-20(26-14)31(4)5)28-22-17-13-32(24(2,3)21(17)29-30-22)23(33)27-18-11-16(18)15-9-7-6-8-10-15/h6-10,12,16,18H,11,13H2,1-5H3,(H,27,33)(H2,25,26,28,29,30)/t16-,18+/m0/s1
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 96n/an/an/a 1.47E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101640
PNG
(US8530652, 85)
Show SMILES CC1(C)N(Cc2c(Nc3ncnc4ccccc34)[nH]nc12)C(=O)NC1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C25H25N7O/c1-25(2)21-18(13-32(25)24(33)28-20-12-17(20)15-8-4-3-5-9-15)23(31-30-21)29-22-16-10-6-7-11-19(16)26-14-27-22/h3-11,14,17,20H,12-13H2,1-2H3,(H,28,33)(H2,26,27,29,30,31)/t17-,20?/m0/s1
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 100n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101477
PNG
(US8524710, 54 | US8530652, 4 | US8530652, 48)
Show SMILES CC1(C)N(Cc2c(Nc3cc(Cl)nc(Cl)n3)[nH]nc12)C(=O)NC1C[C@@H]1c1ccccc1 |r|
Show InChI InChI=1S/C21H21Cl2N7O/c1-21(2)17-13(18(29-28-17)26-16-9-15(22)25-19(23)27-16)10-30(21)20(31)24-14-8-12(14)11-6-4-3-5-7-11/h3-7,9,12,14H,8,10H2,1-2H3,(H,24,31)(H2,25,26,27,28,29)/t12-,14?/m1/s1
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 110n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101553
PNG
(US8530494, 215 | US8530652, 132 | US8530652, 80)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ncncc3F)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C22H26FN7O2/c1-22(2)18-15(19(28-27-18)26-20-16(23)10-24-13-25-20)11-30(22)21(31)32-17(12-29(3)4)14-8-6-5-7-9-14/h5-10,13,17H,11-12H2,1-4H3,(H2,24,25,26,27,28)/t17-/m1/s1
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 120n/an/an/a 20n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101483
PNG
(US8524710, 60 | US8530652, 10 | US8530652, 54)
Show SMILES COc1nc(Cl)nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)n1
Show InChI InChI=1S/C21H23ClN8O2/c1-21(2)15-13(16(29-28-15)24-18-25-17(22)26-19(27-18)32-3)10-30(21)20(31)23-14-9-12(14)11-7-5-4-6-8-11/h4-8,12,14H,9-10H2,1-3H3,(H,23,31)(H2,24,25,26,27,28,29)
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 120n/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101496
PNG
(US8524710, 74 | US8530652, 23 | US8530652, 67)
Show SMILES CN(C)c1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(n1)N1CCC[C@H]1CO |r|
Show InChI InChI=1S/C27H36N10O2/c1-27(2)21-19(14-37(27)26(39)28-20-13-18(20)16-9-6-5-7-10-16)22(34-33-21)29-23-30-24(35(3)4)32-25(31-23)36-12-8-11-17(36)15-38/h5-7,9-10,17-18,20,38H,8,11-15H2,1-4H3,(H,28,39)(H2,29,30,31,32,33,34)/t17-,18+,20?/m0/s1
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 140n/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101527
PNG
(US8530494, 12 | US8530652, 105 | US8530652, 54)
Show SMILES CCc1cc(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)ncn1 |r|
Show InChI InChI=1S/C24H32N8O/c1-6-17-12-20(26-15-25-17)28-22-18-13-32(24(2,3)21(18)29-30-22)23(33)27-19(14-31(4)5)16-10-8-7-9-11-16/h7-12,15,19H,6,13-14H2,1-5H3,(H,27,33)(H2,25,26,28,29,30)/t19-/m1/s1
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 140n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101522
PNG
(US8530652, 49 | US8530652, 94 | US8530670, 4)
Show SMILES Cc1csc2c(Nc3[nH]nc4c3CN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)C4(C)C)ncnc12 |r|
Show InChI InChI=1S/C24H25N7OS/c1-13-11-33-19-18(13)25-12-26-22(19)28-21-16-10-31(24(2,3)20(16)29-30-21)23(32)27-17-9-15(17)14-7-5-4-6-8-14/h4-8,11-12,15,17H,9-10H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t15-,17+/m1/s1
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 160n/an/an/a 332n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101539
PNG
(US8530494, 106 | US8530652, 117 | US8530652, 66)
Show SMILES COc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 |r|
Show InChI InChI=1S/C23H29FN8O2/c1-23(2)18-15(19(30-29-18)27-20-16(24)11-25-21(28-20)34-5)12-32(23)22(33)26-17(13-31(3)4)14-9-7-6-8-10-14/h6-11,17H,12-13H2,1-5H3,(H,26,33)(H2,25,27,28,29,30)/t17-/m1/s1
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 170n/an/an/a<3.90n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101532
PNG
(US8530494, 201 | US8530652, 110 | US8530652, 59)
Show SMILES CCOc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 |r|
Show InChI InChI=1S/C24H31FN8O2/c1-6-35-22-26-12-17(25)21(29-22)28-20-16-13-33(24(2,3)19(16)30-31-20)23(34)27-18(14-32(4)5)15-10-8-7-9-11-15/h7-12,18H,6,13-14H2,1-5H3,(H,27,34)(H2,26,28,29,30,31)/t18-/m1/s1
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 170n/an/an/a 2.40n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101492
PNG
(US8524710, 70 | US8530652, 19 | US8530652, 63)
Show SMILES COc1nc(Nc2n[nH]c3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(n1)N1CCCC1
Show InChI InChI=1S/C25H31N9O2/c1-25(2)19-17(14-34(25)24(35)26-18-13-16(18)15-9-5-4-6-10-15)20(32-31-19)27-21-28-22(30-23(29-21)36-3)33-11-7-8-12-33/h4-6,9-10,16,18H,7-8,11-14H2,1-3H3,(H,26,35)(H2,27,28,29,30,31,32)
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 190n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101500
PNG
(US8524710, 78 | US8530652, 27 | US8530652, 71)
Show SMILES CC1(C)N(Cc2c(Nc3cccc(n3)C(F)(F)F)[nH]nc12)C(=O)NC1C[C@@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H23F3N6O/c1-22(2)19-15(20(31-30-19)29-18-10-6-9-17(28-18)23(24,25)26)12-32(22)21(33)27-16-11-14(16)13-7-4-3-5-8-13/h3-10,14,16H,11-12H2,1-2H3,(H,27,33)(H2,28,29,30,31)/t14-,16?/m1/s1
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 200n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101499
PNG
(US8524710, 77 | US8530652, 26 | US8530652, 70)
Show SMILES Cc1cc(cc(Nc2n[nH]c3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)n1)C(F)(F)F |r|
Show InChI InChI=1S/C24H25F3N6O/c1-13-9-15(24(25,26)27)10-19(28-13)30-21-17-12-33(23(2,3)20(17)31-32-21)22(34)29-18-11-16(18)14-7-5-4-6-8-14/h4-10,16,18H,11-12H2,1-3H3,(H,29,34)(H2,28,30,31,32)/t16-,18?/m1/s1
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 220n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101478
PNG
(US8524710, 55 | US8530652, 49 | US8530652, 5)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4ccsc34)n[nH]c2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C24H28N8OS/c1-24(2)20-16(21(30-29-20)28-22-19-17(10-11-34-19)25-14-26-22)12-32(24)23(33)27-18(13-31(3)4)15-8-6-5-7-9-15/h5-11,14,18H,12-13H2,1-4H3,(H,27,33)(H2,25,26,28,29,30)/t18-/m1/s1
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 220n/an/an/a 87n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101517
PNG
(US8524699, 44 | US8530652, 44 | US8530652, 89)
Show SMILES Cc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)n1 |r|
Show InChI InChI=1S/C22H24FN7O/c1-12-24-10-16(23)20(25-12)27-19-15-11-30(22(2,3)18(15)28-29-19)21(31)26-17-9-14(17)13-7-5-4-6-8-13/h4-8,10,14,17H,9,11H2,1-3H3,(H,26,31)(H2,24,25,27,28,29)/t14-,17+/m0/s1
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 230n/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101493
PNG
(US8524710, 151 | US8524710, 71 | US8530652, 21 | U...)
Show SMILES COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(n1)N1CCC[C@H]1C(N)=O |r|
Show InChI InChI=1S/C26H32N10O3/c1-26(2)19-16(13-36(26)25(38)28-17-12-15(17)14-8-5-4-6-9-14)21(34-33-19)29-22-30-23(32-24(31-22)39-3)35-11-7-10-18(35)20(27)37/h4-6,8-9,15,17-18H,7,10-13H2,1-3H3,(H2,27,37)(H,28,38)(H2,29,30,31,32,33,34)/t15?,17?,18-/m0/s1
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 240n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101529
PNG
(US8530494, 8 | US8530652, 107 | US8530652, 56)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc(C)c3F)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C23H29FN8O/c1-14-18(24)21(26-13-25-14)28-20-16-11-32(23(2,3)19(16)29-30-20)22(33)27-17(12-31(4)5)15-9-7-6-8-10-15/h6-10,13,17H,11-12H2,1-5H3,(H,27,33)(H2,25,26,28,29,30)/t17-/m1/s1
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 240n/an/an/a 570n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101508
PNG
(US8524710, 87 | US8530652, 35 | US8530652, 80)
Show SMILES Cc1cc2c(Nc3[nH]nc4c3CN(C(=O)N[C@@H]3C[C@H]3c3ccccc3)C4(C)C)ncnc2s1 |r|
Show InChI InChI=1S/C24H25N7OS/c1-13-9-16-20(25-12-26-22(16)33-13)28-21-17-11-31(24(2,3)19(17)29-30-21)23(32)27-18-10-15(18)14-7-5-4-6-8-14/h4-9,12,15,18H,10-11H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t15-,18+/m0/s1
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 260n/an/an/a 262n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101501
PNG
(US8524710, 79 | US8530652, 28 | US8530652, 72)
Show SMILES CC1(C)N(Cc2c(Nc3nccc(n3)C(F)(F)F)[nH]nc12)C(=O)NC1C[C@@H]1c1ccccc1 |r|
Show InChI InChI=1S/C22H22F3N7O/c1-21(2)17-14(18(31-30-17)29-19-26-9-8-16(28-19)22(23,24)25)11-32(21)20(33)27-15-10-13(15)12-6-4-3-5-7-12/h3-9,13,15H,10-11H2,1-2H3,(H,27,33)(H2,26,28,29,30,31)/t13-,15?/m1/s1
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 270n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101510
PNG
(US8524699, 6 | US8530652, 37 | US8530652, 82)
Show SMILES CCOc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)n1 |r|
Show InChI InChI=1S/C23H26FN7O2/c1-4-33-21-25-11-16(24)20(28-21)27-19-15-12-31(23(2,3)18(15)29-30-19)22(32)26-17-10-14(17)13-8-6-5-7-9-13/h5-9,11,14,17H,4,10,12H2,1-3H3,(H,26,32)(H2,25,27,28,29,30)/t14-,17+/m0/s1
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 270n/an/an/a 805n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101482
PNG
(US8524710, 59 | US8530652, 53 | US8530652, 9)
Show SMILES CC1(C)N(Cc2c(Nc3nc(Cl)nc(Cl)n3)[nH]nc12)C(=O)NC1CC1c1ccccc1
Show InChI InChI=1S/C20H20Cl2N8O/c1-20(2)14-12(15(29-28-14)24-18-26-16(21)25-17(22)27-18)9-30(20)19(31)23-13-8-11(13)10-6-4-3-5-7-10/h3-7,11,13H,8-9H2,1-2H3,(H,23,31)(H2,24,25,26,27,28,29)
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 270n/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101487
PNG
(US8524710, 65 | US8530652, 14 | US8530652, 58)
Show SMILES COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(OC)n1 |r|
Show InChI InChI=1S/C22H26N8O3/c1-22(2)16-14(17(29-28-16)24-18-25-19(32-3)27-20(26-18)33-4)11-30(22)21(31)23-15-10-13(15)12-8-6-5-7-9-12/h5-9,13,15H,10-11H2,1-4H3,(H,23,31)(H2,24,25,26,27,28,29)/t13-,15?/m1/s1
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 270n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101540
PNG
(US8530494, 205 | US8530652, 118 | US8530652, 67)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncncc3F)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C22H27FN8O/c1-22(2)18-15(19(29-28-18)27-20-16(23)10-24-13-25-20)11-31(22)21(32)26-17(12-30(3)4)14-8-6-5-7-9-14/h5-10,13,17H,11-12H2,1-4H3,(H,26,32)(H2,24,25,27,28,29)/t17-/m1/s1
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 280n/an/an/a 20n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101551
PNG
(US8530494, 213 | US8530652, 130 | US8530652, 78)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ncnc4n(C)cnc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C24H29N9O2/c1-24(2)19-16(20(30-29-19)28-21-18-22(26-13-25-21)32(5)14-27-18)11-33(24)23(34)35-17(12-31(3)4)15-9-7-6-8-10-15/h6-10,13-14,17H,11-12H2,1-5H3,(H2,25,26,28,29,30)/t17-/m1/s1
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 330n/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101491
PNG
(US8524710, 69 | US8530652, 18 | US8530652, 62)
Show SMILES COc1nc(Nc2n[nH]c3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(n1)N1CC1C
Show InChI InChI=1S/C24H29N9O2/c1-13-11-32(13)21-27-20(28-22(29-21)35-4)26-19-16-12-33(24(2,3)18(16)30-31-19)23(34)25-17-10-15(17)14-8-6-5-7-9-14/h5-9,13,15,17H,10-12H2,1-4H3,(H,25,34)(H2,26,27,28,29,30,31)
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 340n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101520
PNG
(US8530652, 47 | US8530670, 15)
Show SMILES Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)C3(C)C)c2ccsc2n1
Show InChI InChI=1S/C17H11F2N3O2/c18-11-3-1-2-10(16(11)19)17-14(23)7-15(24)22(17)9-4-5-12-13(6-9)21-8-20-12/h1-6,8,17H,7H2,(H,20,21)
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 370n/an/an/a 401n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101516
PNG
(US8524699, 28 | US8530652, 43 | US8530652, 88)
Show SMILES COc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)n1 |r|
Show InChI InChI=1S/C22H24FN7O2/c1-22(2)17-14(18(29-28-17)26-19-15(23)10-24-20(27-19)32-3)11-30(22)21(31)25-16-9-13(16)12-7-5-4-6-8-12/h4-8,10,13,16H,9,11H2,1-3H3,(H,25,31)(H2,24,26,27,28,29)/t13-,16+/m0/s1
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 450n/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101481
PNG
(US8524710, 58 | US8530652, 52 | US8530652, 8)
Show SMILES CC1(C)N(Cc2c(Nc3nc(N)nc(Cl)n3)[nH]nc12)C(=O)NC1CC1c1ccccc1
Show InChI InChI=1S/C20H22ClN9O/c1-20(2)14-12(15(29-28-14)24-18-26-16(21)25-17(22)27-18)9-30(20)19(31)23-13-8-11(13)10-6-4-3-5-7-10/h3-7,11,13H,8-9H2,1-2H3,(H,23,31)(H4,22,24,25,26,27,28,29)
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 610n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101497
PNG
(US8524710, 75 | US8530652, 24 | US8530652, 68)
Show SMILES Cc1cc(C)nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)n1 |r|
Show InChI InChI=1S/C23H27N7O/c1-13-10-14(2)25-21(24-13)27-20-17-12-30(23(3,4)19(17)28-29-20)22(31)26-18-11-16(18)15-8-6-5-7-9-15/h5-10,16,18H,11-12H2,1-4H3,(H,26,31)(H2,24,25,27,28,29)/t16-,18?/m1/s1
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 640n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101502
PNG
(US8524710, 80 | US8530652, 29 | US8530652, 73)
Show SMILES CC1(C)N(Cc2c(Nc3cc(ccn3)[N+]#[C-])[nH]nc12)C(=O)NC1C[C@@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H23N7O/c1-23(2)20-17(21(29-28-20)27-19-11-15(24-3)9-10-25-19)13-30(23)22(31)26-18-12-16(18)14-7-5-4-6-8-14/h4-11,16,18H,12-13H2,1-2H3,(H,26,31)(H2,25,27,28,29)/t16-,18?/m1/s1
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 660n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101538
PNG
(US8530494, 208 | US8530652, 116 | US8530652, 65)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ccnc(C)n3)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C23H30N8O/c1-15-24-12-11-19(25-15)27-21-17-13-31(23(2,3)20(17)28-29-21)22(32)26-18(14-30(4)5)16-9-7-6-8-10-16/h6-12,18H,13-14H2,1-5H3,(H,26,32)(H2,24,25,27,28,29)/t18-/m1/s1
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 680n/an/an/a 67.1n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101495
PNG
(US8524710, 73 | US8530652, 22 | US8530652, 66)
Show SMILES CN(C)c1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(n1)N1CCC[C@H]1C(N)=O |r|
Show InChI InChI=1S/C27H35N11O2/c1-27(2)20-17(14-38(27)26(40)29-18-13-16(18)15-9-6-5-7-10-15)22(35-34-20)30-23-31-24(36(3)4)33-25(32-23)37-12-8-11-19(37)21(28)39/h5-7,9-10,16,18-19H,8,11-14H2,1-4H3,(H2,28,39)(H,29,40)(H2,30,31,32,33,34,35)/t16-,18?,19+/m1/s1
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 720n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101490
PNG
(US8524710, 68 | US8530652, 17 | US8530652, 61)
Show SMILES CNC(=O)[C@@H]1CCCN1c1nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(OC)n1 |r|
Show InChI InChI=1S/C27H34N10O3/c1-27(2)20-17(14-37(27)26(39)29-18-13-16(18)15-9-6-5-7-10-15)21(35-34-20)30-23-31-24(33-25(32-23)40-4)36-12-8-11-19(36)22(38)28-3/h5-7,9-10,16,18-19H,8,11-14H2,1-4H3,(H,28,38)(H,29,39)(H2,30,31,32,33,34,35)/t16?,18?,19-/m0/s1
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 770n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101498
PNG
(US8524710, 76 | US8530652, 25 | US8530652, 69)
Show SMILES CC1(C)N(Cc2c(Nc3cc(ccn3)C(F)(F)F)n[nH]c12)C(=O)NC1C[C@@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H23F3N6O/c1-22(2)19-16(20(31-30-19)29-18-10-14(8-9-27-18)23(24,25)26)12-32(22)21(33)28-17-11-15(17)13-6-4-3-5-7-13/h3-10,15,17H,11-12H2,1-2H3,(H,28,33)(H2,27,29,30,31)/t15-,17?/m1/s1
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 780n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101530
PNG
(US8530494, 29 | US8530494, 7 | US8530652, 57)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4n(C)cnc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C24H30N10O/c1-24(2)19-16(20(31-30-19)29-21-18-22(26-13-25-21)33(5)14-27-18)11-34(24)23(35)28-17(12-32(3)4)15-9-7-6-8-10-15/h6-10,13-14,17H,11-12H2,1-5H3,(H,28,35)(H2,25,26,29,30,31)/t17-/m1/s1
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 940n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101484
PNG
(US8524710, 61 | US8530652, 11 | US8530652, 55)
Show SMILES CSc1nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)cc(n1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N7OS/c1-22(2)18-14(11-33(22)21(34)27-15-9-13(15)12-7-5-4-6-8-12)19(32-31-18)29-17-10-16(23(24,25)26)28-20(30-17)35-3/h4-8,10,13,15H,9,11H2,1-3H3,(H,27,34)(H2,28,29,30,31,32)
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 960n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101521
PNG
(US8530652, 48 | US8530652, 93 | US8530670, 3)
Show SMILES CC1(C)N(Cc2c(Nc3ncncc3F)[nH]nc12)C(=O)N[C@H]1C[C@@H]1c1ccccc1 |r|
Show InChI InChI=1S/C21H22FN7O/c1-21(2)17-14(18(28-27-17)26-19-15(22)9-23-11-24-19)10-29(21)20(30)25-16-8-13(16)12-6-4-3-5-7-12/h3-7,9,11,13,16H,8,10H2,1-2H3,(H,25,30)(H2,23,24,26,27,28)/t13-,16+/m1/s1
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 1.00E+3n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101555
PNG
(US8530494, 111 | US8530652, 135)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(Nc3ncnc(C)c3F)[nH]nc2C1(C)C |r|
Show InChI InChI=1S/C21H29FN8O/c1-12-8-28-7-5-6-14(28)9-29(12)20(31)30-10-15-17(21(30,3)4)26-27-18(15)25-19-16(22)13(2)23-11-24-19/h11-12,14H,5-10H2,1-4H3,(H2,23,24,25,26,27)/t12-,14-/m0/s1
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 2.50E+3n/an/an/an/an/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101528
PNG
(US8530494, 6 | US8530652, 106 | US8530652, 55)
Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ccnc(n3)C(F)(F)F)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C23H27F3N8O/c1-22(2)18-15(19(32-31-18)29-17-10-11-27-20(30-17)23(24,25)26)12-34(22)21(35)28-16(13-33(3)4)14-8-6-5-7-9-14/h5-11,16H,12-13H2,1-4H3,(H,28,35)(H2,27,29,30,31,32)/t16-/m1/s1
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n/an/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101512
PNG
(US8524699, 16 | US8530652, 39 | US8530652, 84)
Show SMILES Cc1nccc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)n1 |r|
Show InChI InChI=1S/C22H25N7O/c1-13-23-10-9-18(24-13)26-20-16-12-29(22(2,3)19(16)27-28-20)21(30)25-17-11-15(17)14-7-5-4-6-8-14/h4-10,15,17H,11-12H2,1-3H3,(H,25,30)(H2,23,24,26,27,28)/t15-,17+/m0/s1
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n/an/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101486
PNG
(US8524710, 63 | US8530652, 13 | US8530652, 57)
Show SMILES CC1(C)N(Cc2c(Nc3nc(Cl)nc(n3)N3CCC[C@H]3C(N)=O)[nH]nc12)C(=O)NC1C[C@@H]1c1ccccc1 |r|
Show InChI InChI=1S/C25H29ClN10O2/c1-25(2)18-15(12-36(25)24(38)28-16-11-14(16)13-7-4-3-5-8-13)20(34-33-18)29-22-30-21(26)31-23(32-22)35-10-6-9-17(35)19(27)37/h3-5,7-8,14,16-17H,6,9-12H2,1-2H3,(H2,27,37)(H,28,38)(H2,29,30,31,32,33,34)/t14-,16?,17+/m1/s1
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n/an/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM101509
PNG
(US8524699, 3 | US8530652, 36 | US8530652, 81)
Show SMILES Cn1cnc2c(Nc3[nH]nc4c3CN(C(=O)N[C@@H]3C[C@H]3c3ccccc3)C4(C)C)ncnc12 |r|
Show InChI InChI=1S/C23H25N9O/c1-23(2)18-15(10-32(23)22(33)27-16-9-14(16)13-7-5-4-6-8-13)19(30-29-18)28-20-17-21(25-11-24-20)31(3)12-26-17/h4-8,11-12,14,16H,9-10H2,1-3H3,(H,27,33)(H2,24,25,28,29,30)/t14-,16+/m0/s1
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US Patent
n/an/an/an/a>4.00E+3n/an/an/an/a



Agouron Pharmaceuticals, Inc.; Pfizer Inc.

US Patent


Assay Description
The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...

US Patent US8530652 (2013)


BindingDB Entry DOI: 10.7270/Q2F18XC4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%