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Compile Data Set for Download or QSAR

Found 28 hits of ki for UniProtKB: P14679   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Homo sapiens (Human))
BDBM50559076
PNG
(CHEMBL4743159)
Show SMILES CC(C)C(=O)Nc1nc(cs1)-c1ccc(O)cc1O
KEGG

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250n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205807
PNG
(CHEMBL3978212)
Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1
Show InChI InChI=1S/C14H9NO5/c16-9-2-3-10-11(6-9)20-12(14(10)18)5-8-1-4-13(17)15(19)7-8/h1-7,16,19H/b12-5-
KEGG

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350n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
BindingDB Entry DOI: 10.7270/Q2CN77C2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205807
PNG
(CHEMBL3978212)
Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1
Show InChI InChI=1S/C14H9NO5/c16-9-2-3-10-11(6-9)20-12(14(10)18)5-8-1-4-13(17)15(19)7-8/h1-7,16,19H/b12-5-
KEGG

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350n/an/an/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205807
PNG
(CHEMBL3978212)
Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1
Show InChI InChI=1S/C14H9NO5/c16-9-2-3-10-11(6-9)20-12(14(10)18)5-8-1-4-13(17)15(19)7-8/h1-7,16,19H/b12-5-
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350n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
BindingDB Entry DOI: 10.7270/Q2CN77C2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205815
PNG
(CHEMBL3907670)
Show SMILES Oc1cccc2O\C(=C/c3ccc(=O)n(O)c3)C(=O)c12
Show InChI InChI=1S/C14H9NO5/c16-9-2-1-3-10-13(9)14(18)11(20-10)6-8-4-5-12(17)15(19)7-8/h1-7,16,19H/b11-6-
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1.02E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
BindingDB Entry DOI: 10.7270/Q2CN77C2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205815
PNG
(CHEMBL3907670)
Show SMILES Oc1cccc2O\C(=C/c3ccc(=O)n(O)c3)C(=O)c12
Show InChI InChI=1S/C14H9NO5/c16-9-2-1-3-10-13(9)14(18)11(20-10)6-8-4-5-12(17)15(19)7-8/h1-7,16,19H/b11-6-
KEGG

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1.02E+3n/an/an/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205815
PNG
(CHEMBL3907670)
Show SMILES Oc1cccc2O\C(=C/c3ccc(=O)n(O)c3)C(=O)c12
Show InChI InChI=1S/C14H9NO5/c16-9-2-1-3-10-13(9)14(18)11(20-10)6-8-4-5-12(17)15(19)7-8/h1-7,16,19H/b11-6-
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1.02E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
BindingDB Entry DOI: 10.7270/Q2CN77C2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205806
PNG
(CHEMBL3969839)
Show SMILES Oc1cc2O\C(=C/c3ccc(=O)n(O)c3)C(=O)c2c(O)c1
Show InChI InChI=1S/C14H9NO6/c16-8-4-9(17)13-10(5-8)21-11(14(13)19)3-7-1-2-12(18)15(20)6-7/h1-6,16-17,20H/b11-3-
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1.20E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
BindingDB Entry DOI: 10.7270/Q2CN77C2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205806
PNG
(CHEMBL3969839)
Show SMILES Oc1cc2O\C(=C/c3ccc(=O)n(O)c3)C(=O)c2c(O)c1
Show InChI InChI=1S/C14H9NO6/c16-8-4-9(17)13-10(5-8)21-11(14(13)19)3-7-1-2-12(18)15(20)6-7/h1-6,16-17,20H/b11-3-
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1.20E+3n/an/an/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205806
PNG
(CHEMBL3969839)
Show SMILES Oc1cc2O\C(=C/c3ccc(=O)n(O)c3)C(=O)c2c(O)c1
Show InChI InChI=1S/C14H9NO6/c16-8-4-9(17)13-10(5-8)21-11(14(13)19)3-7-1-2-12(18)15(20)6-7/h1-6,16-17,20H/b11-3-
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1.20E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
BindingDB Entry DOI: 10.7270/Q2CN77C2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50240041
PNG
(1-phenyl-2-thiourea | 1-phenylthiourea | CHEMBL263...)
Show SMILES NC(=S)Nc1ccccc1
Show InChI InChI=1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10)
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1.70E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Uncompetitive inhibition of recombinant human tyrosinase expressed in baculovirus infected sf9 cells using L-DOPA as substrate by double-reciprocal p...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50206007
PNG
(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)
Show SMILES Oc1cc2ccccc2oc1=O
Show InChI InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H
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3.40E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human tyrosinase expressed in Escherichia coli


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50248158
PNG
(CHEMBL450195 | N-butylresorcinol | US8993596, 4-Bu...)
Show SMILES CCCCc1ccc(O)cc1O
Show InChI InChI=1S/C10H14O2/c1-2-3-4-8-5-6-9(11)7-10(8)12/h5-7,11-12H,2-4H2,1H3
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9.10E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50198715
PNG
((2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)pr...)
Show SMILES N[C@@H](Cn1ccc(=O)c(O)c1)C(O)=O
Show InChI InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
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1.03E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected sf9 cells using L-DOPA as substrate by double-reciprocal plo...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50330108
PNG
(2-(ethylthiomethyl)-5-hydroxy-4H-pyran-4-one | CHE...)
Show SMILES CCSCc1cc(=O)c(O)co1
Show InChI InChI=1S/C8H10O3S/c1-2-12-5-6-3-7(9)8(10)4-11-6/h3-4,10H,2,5H2,1H3
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1.90E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM240731
PNG
(US9422261, 4-(1- phenylethyl) benzene-1,3- diol)
Show SMILES CC(c1ccccc1)c1ccc(O)cc1O
Show InChI InChI=1S/C14H14O2/c1-10(11-5-3-2-4-6-11)13-8-7-12(15)9-14(13)16/h2-10,15-16H,1H3
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2.40E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50330109
PNG
(5-hydroxy-2-(propylthiomethyl)-4H-pyran-4-one | CH...)
Show SMILES CCCSCc1cc(=O)c(O)co1
Show InChI InChI=1S/C9H12O3S/c1-2-3-13-6-7-4-8(10)9(11)5-12-7/h4-5,11H,2-3,6H2,1H3
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2.70E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50292636
PNG
(4-hexyl resorcinol | ACRISORCIN | CHEMBL443605)
Show SMILES CCCCCCc1ccc(O)cc1O
Show InChI InChI=1S/C12H18O2/c1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h7-9,13-14H,2-6H2,1H3
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3.90E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50330111
PNG
(5-hydroxy-2-(pentylthiomethyl)-4H-pyran-4-one | CH...)
Show SMILES CCCCCSCc1cc(=O)c(O)co1
Show InChI InChI=1S/C11H16O3S/c1-2-3-4-5-15-8-9-6-10(12)11(13)7-14-9/h6-7,13H,2-5,8H2,1H3
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4.60E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50559094
PNG
(CHEMBL4751526)
Show SMILES CSCc1cc(=O)c(O)co1
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4.60E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50559095
PNG
(CHEMBL4746238)
Show SMILES CC(C)SCc1cc(=O)c(O)co1
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5.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50559087
PNG
(CHEMBL4794995)
Show SMILES CCCn1cc(O)c(=O)cc1C
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7.50E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50559088
PNG
(CHEMBL4777553)
Show SMILES CCCCn1cc(O)c(=O)cc1C
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1.00E+5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205814
PNG
(CHEMBL3898657)
Show SMILES Oc1cccc[n+]1[O-]
Show InChI InChI=1S/C5H5NO2/c7-5-3-1-2-4-6(5)8/h1-4,7H
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1.28E+5n/an/an/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205814
PNG
(CHEMBL3898657)
Show SMILES Oc1cccc[n+]1[O-]
Show InChI InChI=1S/C5H5NO2/c7-5-3-1-2-4-6(5)8/h1-4,7H
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UniChem
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1.28E+5n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human tyrosinase


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
BindingDB Entry DOI: 10.7270/Q2CN77C2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205814
PNG
(CHEMBL3898657)
Show SMILES Oc1cccc[n+]1[O-]
Show InChI InChI=1S/C5H5NO2/c7-5-3-1-2-4-6(5)8/h1-4,7H
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1.28E+5n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human tyrosinase


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
BindingDB Entry DOI: 10.7270/Q2CN77C2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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Article
PubMed
3.50E+5n/an/an/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM197302
PNG
(Benzoic acid | SAMPL4, O1)
Show SMILES OC(=O)c1ccccc1
Show InChI InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)
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5.20E+5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Mixed inhibition of recombinant human tyrosinase expressed in baculovirus infected sf9 cells using L-DOPA as substrate by double-reciprocal plot anal...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00994
BindingDB Entry DOI: 10.7270/Q2PV6Q29
More data for this
Ligand-Target Pair