The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28277660 |
30 |
Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold. |
Shanghai Institute of Materia Medica |
28076827 |
27 |
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity. |
Universit£ |
27918994 |
18 |
Importance of 5/6-aryl substitution on the pharmacological profile of 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived PPAR¿ agonists. |
University of Innsbruck |
28117121 |
9 |
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPAR¿ and SUR agonists. |
Al-Azhar University |
27876250 |
60 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH |
Jagiellonian University Medical College |
27560282 |
11 |
Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR)¿ partial agonists. |
University of Innsbruck |
27569195 |
16 |
New telmisartan-derived PPAR¿ agonists: Impact of the 3D-binding mode on the pharmacological profile. |
Universit£T Innsbruck |
27815118 |
112 |
Discovery of phenoxyindazoles and phenylthioindazoles as ROR¿ inverse agonists. |
Galderma R & D |
27591006 |
24 |
Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptora/d (PPARa/d) dual agonistic activity. |
The University of Tokyo |
27326332 |
66 |
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist. |
Bristol-Myers Squibb |
26988801 |
55 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. |
Jagiellonian University Medical College |
26819660 |
82 |
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor. |
Central Pharmaceutical Research Institute |
27020685 |
4 |
Synthetic approaches to the 2014 new drugs. |
Pfizer |
26731300 |
3 |
Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
Max Planck Institute For Molecular Genetics |
26595749 |
77 |
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor¿ Modulators. |
Goethe-University Frankfurt |
26708109 |
10 |
Design and synthesis of novel Y-shaped barbituric acid derivatives as PPAR¿ activators. |
National Institute of Pharmaceutical Education and Research (NIPER) |
26707398 |
2 |
Characterization of isobutylhydroxyamides with NGF-potentiating activity from Zanthoxylum bungeanum. |
Northwest A & F University |
26258602 |
39 |
Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3. |
Pfizer |
26226490 |
23 |
Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation. |
Iqm-Csic |
26048793 |
91 |
Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. |
Genentech |
25982078 |
13 |
Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor¿/d agonists. |
Sookmyung Women'S University |
25583100 |
107 |
Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands. |
Goethe-University Frankfurt |
25262940 |
3 |
2-(2-Bromophenyl)-formononetin and 2-heptyl-formononetin are PPAR¿ partial agonists and reduce lipid accumulation in 3T3-L1 adipocytes. |
University of Copenhagen |
25938459 |
1 |
Amorfrutins Are Natural PPAR¿ Agonists with Potent Anti-inflammatory Properties. |
Max Planck Institute For Molecular Genetics |
25890697 |
6 |
Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions. |
Punjabi University |
25734377 |
11 |
Peroxisome Proliferator-Activated Receptor¿ (PPAR¿) and Ligand Choreography: Newcomers Take the Stage. |
Universitat Rovira I Virgili (Urv) |
25815144 |
17 |
Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist. |
Daiichi Sankyo |
25978962 |
8 |
Separation and peroxisome proliferator-activated receptor-¿ agonist activity evaluation of synthetic racemic bavachinin enantiomers. |
Shanghai University of Traditional Chinese Medicine |
25686852 |
191 |
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARa/¿ agonists. |
Bristol-Myers Squibb Research and Development (R & D) |
25575659 |
124 |
SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease. |
Goethe-University Frankfurt |
25497132 |
34 |
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptora/¿ ligand LT175. |
Universit£ |
25037914 |
76 |
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARa/¿ activation and dual 5-LO/mPGES-1 inhibition. |
Goethe-University Frankfurt |
25022880 |
24 |
Molecular determinants for improved activity at PPARa: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARa. |
Goethe-University Frankfurt |
25017035 |
20 |
Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPAR¿ agonists. |
Okayama University |
24881566 |
140 |
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). |
Glaxosmithkline |
25491112 |
19 |
Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-a (PPAR-a) agonists. |
National Institute of Pharmaceutical Education and Research (NIPER) |
25462281 |
17 |
Structural development studies of PPARs ligands based on tyrosine scaffold. |
Universit£&Quot;G. D'Annunzio&Quot |
25333853 |
6 |
Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects. |
Karl-Franzens-University Graz |
25305688 |
41 |
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t. |
Phenex Pharmaceuticals |
25255039 |
45 |
Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist. |
Goethe-University Frankfurt |
24821375 |
5 |
The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-a and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells. |
Korea University |
24745969 |
36 |
Identification of the first potent, selective and bioavailable PPARa antagonist. |
Inception Sciences |
9836620 |
94 |
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. |
Glaxo Wellcome Research and Development |
23294830 |
88 |
Discovery of INT131: a selective PPAR¿ modulator that enhances insulin sensitivity. |
Amgen |
23286787 |
18 |
Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor¿. |
Helmholtz Centre For Infection Research |
23265844 |
18 |
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists. |
The University of Sydney |
23265881 |
49 |
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿. |
Pfizer |
24900572 |
54 |
Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes. |
Pfizer |
23171045 |
38 |
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptora/¿ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression. |
Universit� |
17533125 |
36 |
Co-crystal structure guided array synthesis of PPARgamma inverse agonists. |
Glaxosmithkline |
17482722 |
22 |
QSAR analysis of PPAR-gamma agonists as anti-diabetic agents. |
Central Drug Research Institute |
21414782 |
178 |
Phenoxyacetic acids as PPARd partial agonists: synthesis, optimization, and in vivo efficacy. |
Glaxosmithkline |
20444603 |
2 |
Flexible ligand recognition of peroxisome proliferator-activated receptor-gamma (PPARgamma). |
Rikkyo University |
20128594 |
51 |
Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist. |
Glaxosmithkline |
23186307 |
2 |
PPAR¿ agonist from Chromolaena odorata. |
Hebei Medical University |
23102891 |
34 |
Synthesis and structure-activity relationships of fibrate-based analogues inside PPARs. |
Universit£ |
23084275 |
48 |
Design, synthesis and evaluation of novel zwitterionic compounds as PPARa/¿ dual agonists (1). |
Daiichi Sankyo |
22081932 |
32 |
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. |
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot |
23130964 |
25 |
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors. |
Zafes/Liff/Osf Goethe-University Frankfurt |
22934537 |
4 |
Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor¿. |
Universit£ |
22424975 |
4 |
Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists. |
National Kaohsiung Normal University |
23031596 |
21 |
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-¿B activation and PPAR transcriptional activity. |
Chungnam National University |
23022278 |
14 |
Design, synthesis and in vitro evaluation of a series ofa-substituted phenylpropanoic acid PPAR¿ agonists to further investigate the stereochemistry-activity relationship. |
Okayama University |
21800856 |
50 |
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. |
University of Innsbruck |
22324546 |
55 |
Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors. |
Institut Pasteur Korea |
22260081 |
12 |
Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. |
Universit£ |
22582973 |
21 |
Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds. |
Trinity College |
22727448 |
16 |
Synthesis and biological evaluation of novel (-)-Cercosporamide derivatives as potent selective PPAR¿ modulators. |
Daiichi Sankyo |
22564380 |
624 |
Activity landscape modeling of PPAR ligands with dual-activity difference maps. |
Universidad Nacional Aut£Noma De M£Xico |
22534184 |
87 |
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptord agonists as potent anti-obesity agents in vivo. |
Seoul National University |
22424300 |
3 |
Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma. |
Korea University |
22579420 |
45 |
Total synthesis and dual PPARa/¿ agonist effects of amorphastilbol and its synthetic derivatives. |
Korea Institute of Science and Technology |
22503460 |
37 |
Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR)¿ Agonists. |
Takeda Pharmaceutical |
22381047 |
30 |
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii. |
Chungnam National University |
21218783 |
117 |
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents. |
Johnson & Johnson Pharmaceutical Research and Development |
21128600 |
16 |
Design, synthesis, and structural analysis of phenylpropanoic acid-type PPAR¿-selective agonists: discovery of reversed stereochemistry-activity relationship. |
Okayama University |
20527969 |
27 |
Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic acids as peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonists with comparable antidiabetic efficacy to rosiglitazone. |
Kyorin Pharmaceutical |
20299214 |
20 |
(S)-3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(piperazin-1-yl) propanoic acid compounds: synthesis and biological evaluation of dual PPARalpha/gamma agonists. |
Institute of Pharmacology and Toxicology |
20219371 |
22 |
Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives. |
Daiichi Sankyo |
19879669 |
3 |
Identification of (beta-carboxyethyl)-rhodanine derivatives exhibiting peroxisome proliferator-activated receptor gamma activity. |
Sookmyung Women'S University |
20138762 |
5 |
Acidic elements in histamine H(3) receptor antagonists. |
Johann Wolfgang Goethe University |
19574056 |
25 |
Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. |
Chinese Academy of Sciences |
18329752 |
14 |
Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. |
Graduate School of The Chinese Academy of Sciences |
18976908 |
18 |
Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety. |
Zydus Research Centre |
18826205 |
61 |
Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists. |
Seoul National University |
18511276 |
86 |
Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists. |
Bristol-Myers Squibb R & D |
18272370 |
2 |
Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha. |
Usda-Ars |
17062777 |
32 |
Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling. |
Bristol-Myers Squibb |
18155554 |
87 |
Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists. |
Johnson & Johnson Pharmaceutical Research and Development |
17964792 |
31 |
Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists. |
Nippon Shinyaku |
18162399 |
37 |
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail. |
University of Tokyo |
18280733 |
27 |
Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists. |
Nippon Shinyaku |
18083521 |
4 |
Omega-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents. |
Central Drug Research Institute |
18291645 |
108 |
Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists. |
Bristol-Myers Squibb Research and Development |
18029176 |
66 |
Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. |
Johnson & Johnson |
17560785 |
12 |
Design of a partial PPARdelta agonist. |
Novo Nordisk |
17010604 |
3 |
Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I). |
Fudan University |
17005393 |
35 |
Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents. |
Eli Lilly |
16821769 |
16 |
Design and synthesis of the first generation of dithiolane thiazolidinedione- and phenylacetic acid-based PPARgamma agonists. |
University of Mississippi |
16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
12951090 |
57 |
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists. |
Merck Research Laboratories |
10714503 |
18 |
Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship. |
Sankyo |
22342624 |
2 |
Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes. |
Korea University |
22341573 |
39 |
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptorsa/¿ dual agonists. |
Universit£ |
22225641 |
13 |
Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR¿ partial agonists. |
Daiichi Sankyo |
22070604 |
150 |
Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators. |
Merck Research Laboratories |
22209730 |
73 |
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR)¿ agonists: design and synthesis of benzylpyrazole acylsulfonamides. |
Takeda Pharmaceutical |
22197396 |
57 |
Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor¿ selective agonists with protein-tyrosine phosphatase 1B inhibition. |
Kyoto Pharmaceutical Industries |
22133631 |
76 |
Discovery of cyclic amine-substituted benzoic acids as PPARa agonists. |
Kyorin Pharmaceutical |
22051054 |
18 |
Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516. |
University of Oslo |
21873070 |
29 |
SAR studies of acidic dual¿-secretase/PPAR¿ modulators. |
Goethe-University Frankfurt |
21514830 |
39 |
Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: relationship between absolute configuration and subtype selectivity. |
The University of Tokyo |
21450468 |
22 |
Revisiting glitazars: thiophene substituted oxazole containinga-ethoxy phenylpropanoic acid derivatives as highly potent PPARa/¿ dual agonists devoid of adverse effects in rodents. |
Zydus Research Centre |
20850970 |
27 |
Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators. |
Inha University |
21557540 |
39 |
Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿. |
Pfizer |
21482446 |
55 |
Discovery of new nanomolar peroxisome proliferator-activated receptor κ activators via elaborate ligand-based modeling. |
Universiti Sains Malaysia |
19423341 |
6 |
Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives. |
Guiyang Medical College |
21530275 |
42 |
Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR)a-selective agonists. |
Okayama University |
21515063 |
60 |
Biological evaluation of novel benzisoxazole derivatives as PPARd agonists. |
Nippon Chemiphar |
21377875 |
19 |
Synthesis and pharmacological evaluation of novel benzoylazole-based PPARa/κ activators. |
Dainippon Sumitomo Pharma |
21094606 |
24 |
Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARd agonists. |
Astrazeneca R&D Charnwood |
21130649 |
11 |
Development of a new class of benzoylpyrrole-based PPARa/¿ activators. |
Dainippon Sumitomo Pharma |
21112784 |
15 |
Synthesis of a novel human PPARd selective agonist and its stimulatory effect on oligodendrocyte differentiation. |
Nippon Chemiphar |
21215640 |
21 |
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists. |
Zydus Research Centre |
21074432 |
25 |
Selective peroxisome proliferator-activated receptord isosteric selenium agonists as potent anti-atherogenic agents in vivo. |
Seoul National University |
21030263 |
5 |
1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPAR¿ partial agonists. |
Sookmyung Women'S University |
20656494 |
11 |
Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode. |
Freie UniversitäT Berlin |
20638278 |
145 |
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. |
Phenex Pharmaceuticals |
20503989 |
29 |
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity. |
Zafes/Liff/Goethe University Frankfurt |
20471839 |
4 |
Synthesis and anti-inflammatory activity of new arylidene-thiazolidine-2,4-diones as PPARgamma ligands. |
Universidade Federal De Pernambuco |
20452212 |
26 |
Glycine amides as PPARalpha agonists. |
Bayer-Schering Pharma |
20356736 |
48 |
Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation. |
Bristol-Myers Squibb R & D |
20347594 |
7 |
Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators. |
Goethe-University Frankfurt |
20307981 |
16 |
Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator. |
Goethe-University Frankfurt |
20218621 |
131 |
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). |
Bristol-Myers Squibb |
19928766 |
425 |
Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists. |
The Genomics Institute of The Novartis Research Foundation |
19853439 |
21 |
Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists. |
The University of Tokyo |
20022492 |
29 |
Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARalpha agonists. |
Zydus Research Centre |
20079636 |
78 |
Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators. |
Glaxosmithkline |
19807106 |
11 |
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists. |
The University of Sydney |
19775169 |
41 |
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function. |
Universit£ |
19556125 |
42 |
Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists. |
Goethe-University Frankfurt |
19719236 |
23 |
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation. |
Wake Forest University |
19376700 |
21 |
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations. |
Umr Gicc |
19530681 |
79 |
Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia. |
Merck Research Laboratories |
| 22 |
Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands |
TBA |
| 4 |
Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids1 |
TBA |
| 9 |
Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids |
TBA |
19507861 |
18 |
Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma a |
Merck Research Laboratories |
19349176 |
137 |
Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes. |
F. Hoffmann-La Roche |
19301897 |
63 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists. |
National Health Research Institutes |
19275963 |
26 |
Selective, potent PPARgamma agonists with cyclopentenone core structure. |
Universidade De Vigo |
19201606 |
86 |
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. |
Bristol-Myers Squibb Research and Development |
18947994 |
102 |
The discovery of equipotent PPARalpha/gamma dual activators. |
Glaxosmithkline |
18835719 |
42 |
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity. |
Università |
18821746 |
10 |
Discovery of novel PPAR ligands by a virtual screening approach based on pharmacophore modeling, 3D shape, and electrostatic similarity screening. |
University of Innsbruck |
18809325 |
13 |
Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma. |
National Health Research Institutes |
18805005 |
8 |
Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent. |
Zydus Research Centre |
18771917 |
68 |
Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists. |
Yuhan Research Institute |
18701276 |
97 |
Highly functionalized 7-azaindoles as selective PPAR gamma modulators. |
Merck Research Laboratories |
18665581 |
23 |
Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition. |
Vanderbilt University Center For Structural Biology |
18662876 |
45 |
Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part. |
The University of Tokyo |
18625559 |
16 |
Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists. |
Zydus Research Centre |
18477507 |
1 |
Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells. |
Kyoto Pharmaceutical University |
18329751 |
40 |
Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists. |
Graduate School of The Chinese Academy of Sciences |
18321611 |
64 |
CoMFA analysis of dual/multiple PPAR activators. |
National Institute of Pharmaceutical Education and Research |
16643023 |
2 |
Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
University of Mississippi |
11975517 |
3 |
Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma. |
Korea Research Institute of Bioscience and Biotechnology |
18255290 |
28 |
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation. |
Spot-Ea3857 |
18060776 |
100 |
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
Glaxosmithkline |
18044841 |
12 |
Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation. |
Boehringer Ingelheim Pharma |
18029178 |
188 |
Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists. |
Eli Lilly |
18023179 |
58 |
Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity. |
Wyeth Pharmaceuticals |
17624777 |
31 |
Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists. |
Korea Research Institute of Chemical Technology |
17618115 |
1 |
Mycophenolic acid as a latent agonist of PPARgamma. |
Hokkaido University |
17601734 |
102 |
Indanylacetic acids as PPAR-delta activator insulin sensitizers. |
Bayer Research Center |
17574414 |
15 |
Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARgamma activators. |
National Institute of Pharmaceutical Education and Research |
17553681 |
50 |
Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety. |
Re&D Vufb |
17553678 |
97 |
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists. |
Kowa |
17532641 |
57 |
Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists. |
University of Tokyo |
17524643 |
14 |
Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists. |
Nagoya City University |
17524639 |
73 |
Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists. |
Johnson and Johnson Pharmaceutical Research and Development |
17512197 |
101 |
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists. |
Pfizer |
17507225 |
34 |
Design, synthesis, and structure-activity relationship of carbamate-tethered aryl propanoic acids as novel PPARalpha/gamma dual agonists. |
Seoul National University |
17498950 |
69 |
Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists. |
Pfizer |
17379517 |
45 |
Design of potent PPARalpha agonists. |
Novo Nordisk |
17343371 |
27 |
Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo. |
Novo Nordisk |
17292606 |
91 |
Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
17129725 |
90 |
Design and synthesis of a novel class of dual PPARgamma/delta agonists. |
Eli Lilly |
17034149 |
22 |
Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists. |
National Health Research Institutes |
17005394 |
49 |
Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands. |
Eli Lilly |
16979341 |
59 |
Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents. |
Pfizer |
16973358 |
113 |
Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents. |
Pfizer |
16970391 |
88 |
Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile. |
Eli Lilly |
16919947 |
30 |
Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. |
Procter and Gamble Pharmaceuticals |
16854085 |
11 |
Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. |
Korea Research Institute of Chemical Technology |
16797985 |
26 |
Studies towards the conception of new selective PPARbeta/delta ligands. |
Université |
16750626 |
51 |
3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1. |
The Genomics Institute of The Novartis Research Foundation |
16737814 |
112 |
Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists. |
F. Hoffmann-La Roche |
16640330 |
5 |
Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities. |
National Health Research Institutes |
16546385 |
81 |
1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists. |
The Genomics Institute of The Novartis Research Foundation |
16529931 |
139 |
SAR studies: designing potent and selective LXR agonists. |
Merck Research Laboratories |
16451087 |
41 |
Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies. |
National Health Research Institutes |
16384704 |
86 |
Design and synthesis of potent and subtype-selective PPARalpha agonists. |
Merck Research Laboratories |
16366601 |
82 |
Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities. |
National Health Research Institutes |
16275080 |
174 |
Substituted indanylacetic acids as PPAR-alpha-gamma activators. |
Bayer Research Center |
16275077 |
27 |
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists. |
University of Tokyo |
16153845 |
81 |
Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists. |
Merck Research Laboratories |
16137885 |
59 |
Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs. |
Cnrs Umr 6052 |
16107159 |
106 |
Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity. |
Merck Research Laboratories |
16107150 |
39 |
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity. |
Università |
15974597 |
96 |
Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity. |
Merck Research Laboratories |
15950464 |
146 |
(2R)-2-methylchromane-2-carboxylic acids: discovery of selective PPARalpha agonists as hypolipidemic agents. |
Merck Research Laboratories |
15863293 |
30 |
Selective PPARgamma modulators with improved pharmacological profiles. |
Merck Research Laboratories |
15801817 |
32 |
Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia. |
Merck Research Laboratories |
15771468 |
19 |
Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
15603954 |
37 |
Benzoyl 2-methyl indoles as selective PPARgamma modulators. |
Merck Research Laboratories |
15582409 |
46 |
2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents. |
Eli Lilly |
15293980 |
47 |
Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes. |
Glaxosmithkline |
15177462 |
38 |
Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators. |
Research Institute of Tsinghua University |
15163205 |
94 |
(2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents. |
Merck Research Laboratories |
15115385 |
68 |
Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists. |
Eli Lilly |
14695833 |
46 |
Benzoxazinones as PPARgamma agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model. |
Johnson and Johnson Pharmaceutical Research and Development |
14613314 |
53 |
Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. |
Eli Lilly |
14592510 |
150 |
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
Ligand Pharmaceuticals |
14584939 |
32 |
Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo. |
Novo Nordisk |
14505666 |
99 |
Aryloxazolidinediones: identification of potent orally active PPAR dual alpha/gamma agonists. |
Merck Research Laboratories |
12951091 |
36 |
Design and synthesis of fluorinated RXR modulators. |
Eli Lilly |
12904063 |
69 |
Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators. |
Kyorin Pharmaceutical |
12873517 |
90 |
5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents. |
Merck Research Laboratories |
12801232 |
71 |
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
Ligand Pharmaceuticals |
12729668 |
106 |
5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists. |
Merck Research Laboratories |
12699745 |
49 |
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. |
Glaxosmithkline |
12672231 |
18 |
Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar. |
Novo Nordisk |
12657263 |
46 |
Phenylacetic acid derivatives as hPPAR agonists. |
Merck Research Laboratories |
12617924 |
140 |
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists. |
Merck Research Laboratories |
12482434 |
52 |
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template. |
Novo Nordisk |
12443777 |
63 |
Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators. |
Biovitrum |
11906293 |
7 |
Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. |
Takeda Chemical Industries |
11831892 |
46 |
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity. |
Novo Nordisk |
11814790 |
8 |
Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha. |
Kyorin Pharmaceutical |
11738577 |
19 |
Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators. |
Kyorin Pharmaceutical |
11720854 |
48 |
Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight. |
Glaxosmithkline |
11677135 |
21 |
Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis. |
Glaxosmithkline |
11527737 |
70 |
Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta. |
Glaxosmithkline |
32356658 |
32 |
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR?. |
Goethe-University Frankfurt |
11405642 |
33 |
Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists. |
Eli Lilly |
32008883 |
41 |
Anti-diabetic drugs recent approaches and advancements. |
Mizoram University |
11354382 |
42 |
Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
Glaxosmithkline |
32315173 |
8 |
The Oxidation of Phytocannabinoids to Cannabinoquinoids. |
Universit£ |
32435362 |
21 |
Sulfonimide and Amide Derivatives as Novel PPAR? Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies. |
"G. D'Annunzio" University of Chieti-Pescara |
32129622 |
1 |
Polyacetylenes from |
University of Vienna |
31889664 |
20 |
Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPAR? modulators. |
Mitobridge |
31806266 |
17 |
Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor ?. |
Seoul National University |
30776227 |
38 |
Discovery of Second Generation ROR? Inhibitors Composed of an Azole Scaffold. |
Kyoto Prefectural University of Medicine |
27503683 |
12 |
Non-canonical modulators of nuclear receptors. |
Vitae Pharmaceuticals |
31253533 |
14 |
Discovery of BR102375, a new class of non-TZD PPAR? full agonist for the treatment of type 2 diabetes. |
Boryung Pharmaceuticals |
30996794 |
27 |
Novel Phenyldiazenyl Fibrate Analogues as PPAR ?/?/? Pan-Agonists for the Amelioration of Metabolic Syndrome. |
University of Chieti "G. D.Annunzio |
27622746 |
18 |
Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor ?/? (PPAR?/?) dual agonists. |
The University of Tokyo |
30605833 |
68 |
Discovery of first-in-class thiazole-based dual FFA1/PPAR? agonists as potential anti-diabetic agents. |
Guangdong Pharmaceutical University |
30702885 |
256 |
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation. |
Goethe University Frankfurt |
30676741 |
24 |
Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPAR? Drug Pioglitazone. |
The Scripps Research Institute |
10691680 |
72 |
The PPARs: from orphan receptors to drug discovery. |
Glaxo Wellcome Research & Development |
31629632 |
3 |
Novel berberine-based derivatives with potent hypoglycemic activity. |
Guizhou Medical University |
10612594 |
32 |
Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. |
Glaxo Wellcome Research and Development |
31330449 |
9 |
Role of sulphur-heterocycles in medicinal chemistry: An update. |
Maharaja Ranjit Singh Punjab Technical University |
31940200 |
62 |
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. |
Genomics Institute of The Novartis Research Foundation (Gnf) |
10508427 |
42 |
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
Glaxo Wellcome Research & Development |
31471102 |
1 |
Novel thiazolidines: Synthesis, antiproliferative properties and 2D-QSAR studies. |
University of Texas-Arlington |
31112893 |
8 |
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands. |
Universit£ |
31351846 |
2 |
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPAR?-selective agonist. |
University of Oslo |
31082765 |
11 |
Structure-activity relationship and synthetic methodologies of ?-santonin derivatives with diverse bioactivities: A mini-review. |
Shanghai Ocean University |
31320147 |
22 |
Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPAR?)-selective agonists. |
Okayama University |
10098657 |
2 |
(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents. |
Kyorin Pharmaceutical |
31821760 |
53 |
Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor ?t (ROR?t) Inverse Agonists. |
Technische Universiteit Eindhoven |
9934490 |
4 |
Differential activity of rosiglitazone enantiomers at PPAR gamma. |
Glaxo Wellcome Research and Development |
31648125 |
8 |
Overcoming imatinib resistance in chronic myelogenous leukemia cells using non-cytotoxic cell death modulators. |
University of Innsbruck |
31548084 |
28 |
Structure optimization of a new class of PPAR? antagonists. |
Fraunhofer Institute For Molecular Biology and Applied Ecology Ime |
31591015 |
34 |
Design, synthesis, and evaluation of potent novel peroxisome proliferator-activated receptor ? indole partial agonists. |
The University of Oklahoma Health Science Center |
32267688 |
52 |
A Selective Modulator of Peroxisome Proliferator-Activated Receptor ? with an Unprecedented Binding Mode. |
Goethe-University Frankfurt |
31009912 |
5 |
Multitarget PPAR? agonists as innovative modulators of the metabolic syndrome. |
University of Chieti "G. D.Annunzio |
32096640 |
48 |
Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPAR? Agonists as Leads for Retinal Disorders. |
University of Oklahoma |
31930920 |
69 |
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. |
Terns Pharmaceuticals |
31268307 |
10 |
Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPAR?/PPAR? Agonist Activity and Anti-inflammatory Effect. |
University of Valencia |
32071676 |
52 |
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as ROR??t Allosteric Inhibitors for Autoimmune Diseases |
Merck |
30672698 |
5 |
Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of Aquilaria malaccensis. |
Seoul National University |
30594433 |
90 |
Discovery of potent and selective PPAR?/? dual antagonists and initial biological studies. |
Inception Sciences |
30594432 |
30 |
Identification of BR101549 as a lead candidate of non-TZD PPAR? agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. |
Boryung Pharmaceuticals |
31729873 |
43 |
Structure-Based and Property-Driven Optimization of |
Global Discovery Chemistry |
31294974 |
62 |
Mechanistic Insight on the Mode of Action of Colletoic Acid. |
The University of Tennessee Health Science Center |
31623970 |
31 |
Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold. |
Hokkaido University |
31312410 |
24 |
Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor ?/? Agonist for the Treatment of Primary Biliary Cirrhosis. |
Wuxi Apptec (Shanghai) Co. |
26355531 |
7 |
Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo. |
Ume£ |
26616289 |
8 |
Identification of dual PPAR?/? agonists and their effects on lipid metabolism. |
The University of Sydney |
26443549 |
2 |
Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5. |
Universit£ |
26396687 |
95 |
Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPAR? Antagonists. |
The Scripps Research Institute |
25437304 |
12 |
Sterol fatty acid esters from the mushroom Hericium erinaceum and their PPAR transactivational effects. |
Yeungnam University |
24900619 |
42 |
Diphenylpropane Derivatives as Agonist of PPAR Nuclear Receptors. |
Dart Neuroscience |
24075729 |
4 |
Structure-based identification of novel PPAR gamma ligands. |
Universidade Federal Do Abc |
23910984 |
1 |
Adipogenetic effects of retrofractamide A derivatives in 3T3-L1 cells. |
Kyoto Pharmaceutical University |
23731946 |
3 |
Discovery of new PPAR? agonists based on arylopeptoids. |
University of Copenhagen |
23502212 |
53 |
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors ?/? agonists. |
Universit£ |
23490155 |
13 |
Design and synthesis of a series of ?-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility. |
Okayama University |
22364952 |
4 |
Synthesis and antidiabetic performance of ?-amino ketone containing nabumetone moiety. |
Southwest University |
9836622 |
138 |
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent. |
Glaxo Wellcome Research and Development |
9836621 |
181 |
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety. |
Glaxo Wellcome Research and Development |
30351933 |
21 |
Development of Dihydrodibenzooxepine Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Ligands of a Novel Binding Mode as Anticancer Agents: Effective Mimicry of Chiral Structures by Olefinic E/ Z-Isomers. |
Fuji Research Park, R&D Division |
30362739 |
2 |
Stereoselective Synthesis of the Isomers of Notoincisol A: Assigment of the Absolute Configuration of this Natural Product and Biological Evaluation. |
Vienna University of Technology |
30296685 |
86 |
Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPAR? and PPAR?. |
Guangdong Pharmaceutical University |
30177375 |
16 |
Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPAR? derived from the AT1R antagonist, Fimasartan. |
Boryung Pharmaceuticals |
30429097 |
29 |
PPAR?-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development. |
Sptanis Pharmachem Consulting |
29878767 |
21 |
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology. |
Goethe University Frankfurt |
30199253 |
18 |
Identification of the First PPAR?/? Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR? and To Inhibit Its Cdk5-Mediated Phosphorylation. |
Universit£ |
30054191 |
66 |
Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor ? agonist. |
Daegu-Gyeongbuk Medical Innovation Foundation |
30001846 |
3 |
Design, synthesis, and evaluation of novel l-phenylglycine derivatives as potential PPAR? lead compounds. |
Southwest University |
29628329 |
19 |
Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPAR? selective agonists: New leads for oculovascular conditions. |
University of Oklahoma |
29571573 |
34 |
Sulfoximines as potent ROR? inverse agonists. |
Nestle Skin Health |
28667876 |
10 |
A novel structural class of coumarin-chalcone fibrates as PPAR?/? agonists with potent antioxidant activities: Design, synthesis, biological evaluation and molecular docking studies. |
Shenyang Pharmaceutical University |
29398443 |
2 |
2-Formyl-komarovicine promotes adiponectin production in human mesenchymal stem cells through PPAR? partial agonism. |
Seoul National University |
29103972 |
53 |
Novel highly selective peroxisome proliferator-activated receptor ? (PPAR?) modulators with pharmacokinetic properties suitable for once-daily oral dosing. |
Mitobridge |
30241907 |
78 |
Discovery of DS-6930, a potent selective PPAR? modulator. Part I: Lead identification. |
Daiichi Sankyo |
30220602 |
67 |
Discovery of DS-6930, a potent selective PPAR? modulator. Part II: Lead optimization. |
Daiichi Sankyo |
29259758 |
26 |
SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists. |
Sungkyunkwan University |
28609708 |
39 |
Anti-diabetic activity of fused PPAR?-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression. |
University of Lille |
28735214 |
54 |
Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents. |
Janssen Research and Development |
29615345 |
11 |
Synthesis, biological evaluation, and molecular docking investigation of benzhydrol- and indole-based dual PPAR-?/FFAR1 agonists. |
Suez Canal University |
28720328 |
29 |
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of quinazolin-4(3H)-one derivatives as potential PPAR? and SUR agonists. |
Al-Azhar University |
28112924 |
149 |
Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode. |
Bristol-Myers Squibb |
29446942 |
98 |
Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR)?/?/? Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate. |
Inventiva |
29316397 |
47 |
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists. |
Bristol-Myers Squibb |
28539218 |
25 |
Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor?/? (PPAR?/?) dual agonists. |
The University of Tokyo |
28465099 |
26 |
Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression. |
The University of Tokyo |
28845983 |
81 |
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis. |
Goethe-University Frankfurt |
28799755 |
51 |
Polypharmacology of N |
Sahmyook University |
28485590 |
15 |
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPAR?-Targeted Antidiabetics. |
The Scripps Research Institute |
11160654 |
10 |
Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea. |
Kitasato University |
10991998 |
32 |
Cannabinoid agonist signal transduction in rat brain: comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition. |
Wake Forest University |
21671327 |
5 |
Triptolide directly inhibits dCTP pyrophosphatase. |
Yale University |
8474008 |
58 |
Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities. |
Virginia Commonwealth University |
20373302 |
5 |
The identification of a novel natural activator of p300 histone acetyltranferase provides new insights into the modulation mechanism of this enzyme. |
Universitá |
19827080 |
10 |
A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry. |
University of Cambridge |
19954435 |
116 |
Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. |
Queen'S University |
19843080 |
43 |
The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay. |
Pfizer |
8461029 |
21 |
Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese hamster ovary cells. [3H]spiperone discriminates between the G-protein-coupled and -uncoupled forms. |
University of Canterbury |
8413837 |
45 |
[3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments. |
Boots Pharmaceuticals |
8394987 |
32 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. |
Cnrs |
18089721 |
10 |
New inhibitors of ABCG2 identified by high-throughput screening. |
Saic-Frederick |