The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28621538 |
63 |
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. |
Novartis Pharma |
28089698 |
10 |
Novel 2,4-dichlorophenoxy acetic acid substituted thiazolidin-4-ones as anti-inflammatory agents: Design, synthesis and biological screening. |
Jamia Hamdard (Hamdard University) |
27894044 |
37 |
An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. |
University of Kwazulu-Natal |
27597418 |
16 |
Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins. |
Bhupat and Jyoti Mehta School of Biosciences |
27842798 |
66 |
Synthesis, COX-1/2 inhibition activities and molecular docking study of isothiazolopyridine derivatives. |
Wroclaw Medical University |
27349331 |
42 |
Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis. |
Nanjing University |
27046190 |
10 |
Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design. |
Tu Dortmund University |
26372652 |
21 |
Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities. |
Rwth Aachen University |
26123643 |
90 |
Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase. |
University of Jena |
26048794 |
22 |
Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2. |
Bangalore University |
25768707 |
17 |
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model. |
Universit£ |
25866240 |
56 |
Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors. |
The First Affiliated Hospital of Nanjing Medical University |
24934992 |
50 |
Novel pyrazoline derivatives as bi-inhibitor of COX-2 and B-Raf in treating cervical carcinoma. |
Second Affiliated Hospital of Southeast University |
25453800 |
3 |
Synthesis and PGE2 production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells. |
TBA |
25442305 |
4 |
Bioactive compounds from the insect Aspongopus chinensis. |
Chinese Academy of Sciences |
25408841 |
108 |
Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors. |
Vanderbilt University School of Medicine |
25313331 |
34 |
Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
Institutes of Biomedicine and Health |
24920381 |
77 |
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. |
University Jena |
24836072 |
38 |
Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression. |
Jamia Hamdard (Hamdard University) |
23473947 |
28 |
Synthesis, cyclooxygenase inhibitory effects, and molecular modeling study of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and -2-alkylsulfonyl-1H-imidazole derivatives. |
Tehran University of Medical Sciences |
23534442 |
32 |
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors. |
Universit£ |
23454516 |
92 |
Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3. |
University of Auckland |
23353741 |
117 |
Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents. |
Hefei University of Technology |
23432095 |
160 |
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17ß-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. |
Vanderbilt University School of Medicine |
15603946 |
67 |
QSAR studies on structurally similar 2-(4-methanesulfonylphenyl)pyran-4-ones as selective COX-2 inhibitors: a Hansch approach. |
Devi Ahilya Vishwavidyalaya |
14552773 |
59 |
Exploring selectivity requirements for COX-2 versus COX-1 binding of 3,4-diaryloxazolones using E-state index. |
Jadavpur University |
23146282 |
3 |
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones. |
Devi Ahilya Vishwavidyalaya |
21413808 |
170 |
Synopsis of some recent tactical application of bioisosteres in drug design. |
Bristol-Myers Squibb Pharmaceutical Research and Development |
22652053 |
6 |
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins. |
Rwth Aachen University |
23062711 |
42 |
Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors. |
Nanjing University |
24900267 |
9 |
Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable ¿-Secretase Modulator. |
TBA |
22404396 |
16 |
Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity. |
Keio University |
22263894 |
23 |
Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. |
Vanderbilt Institute of Chemical Biology |
22236250 |
16 |
Exploring activity cliffs in medicinal chemistry. |
Rheinische Friedrich-Wilhelms-Universit£T |
22507964 |
17 |
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer. |
Perelman School of Medicine University of Pennsylvania |
22469703 |
32 |
Isoquinoline derivatives as potent CRTH2 receptor antagonists: synthesis and SAR. |
Taisho Pharmaceutical |
22386242 |
13 |
N-Caffeoyl serotonin as selective COX-2 inhibitor. |
Kinki University |
20576329 |
14 |
3-Formylchromones: potential antiinflammatory agents. |
University of Karachi |
20451397 |
55 |
Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. |
Universit£ |
19791801 |
86 |
Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors. |
University of Liege |
11858749 |
32 |
Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. |
University of Illinois At Chicago |
9784154 |
12 |
Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. |
Uppsala University |
16038536 |
88 |
Expanding the ChemGPS chemical space with natural products. |
Uppsala University |
18363350 |
60 |
Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. |
Okayama University Graduate School of Medicine |
18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
University of Oxford |
18191402 |
4 |
Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems. |
University of Sciences and Technology Houari Boum£Di£Ne |
18063374 |
68 |
Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. |
Taipei Medical University |
17994684 |
48 |
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors. |
Nitromed |
17517512 |
33 |
Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system. |
Universitat De Barcelona |
17346963 |
12 |
Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill). |
Institute For Natural Product Research and Infection Biology |
16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
12672248 |
50 |
Kinase inhibitors: not just for kinases anymore. |
Northwestern University |
11906292 |
32 |
4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1). |
Central Pharmaceutical Research Institute |
11101350 |
72 |
1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite. |
Institut De Recherche Servier |
10649977 |
72 |
Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors. |
RhôNe-Poulenc Rorer |
10197970 |
88 |
2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
10508425 |
68 |
Mixture-based synthetic combinatorial libraries. |
Torrey Pines Institute For Molecular Studies |
15177483 |
33 |
SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity. |
Novartis Institutes For Biomedical Research |
10406640 |
31 |
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor. |
Merck Frosst Centre For Therapeutic Research |
| 6 |
The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries |
TBA |
22373734 |
42 |
Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug. |
Pfizer |
21602044 |
6 |
Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo. |
Shanghai Haini Pharmaceutical |
24900317 |
11 |
Indomethacin Analogues that Enhance Doxorubicin Cytotoxicity in Multidrug Resistant Cells without Cox Inhibitory Activity. |
TBA |
22189137 |
2 |
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation. |
University of Genoa |
21992176 |
52 |
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties. |
Sapienza University of Rome |
22059882 |
206 |
5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. |
Amira Pharmaceuticals |
22000948 |
50 |
Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors. |
Nanjing University |
21958738 |
6 |
Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase. |
Universiti Putra Malaysia |
21868137 |
69 |
Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils. |
Gazi University |
21752640 |
6 |
Bioactive sulfoximines: syntheses and properties of Vioxx analogs. |
Rwth Aachen University |
21570308 |
55 |
Synthesis and biological evaluation of loxoprofen derivatives. |
Kumamoto University |
21542630 |
135 |
Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase. |
Peking University |
21345672 |
28 |
Synthesis, biological evaluation and molecular docking studies of stellatin derivatives as cyclooxygenase (COX-1, COX-2) inhibitors and anti-inflammatory agents. |
National Institute of Pharmaceutical Education and Research (NIPER) |
21215625 |
40 |
Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors. |
Pfizer |
21211969 |
42 |
Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist. |
Amira Pharmaceuticals |
21106277 |
1 |
Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities. |
Aristotelian University of Thessaloniki |
20970223 |
10 |
Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents. |
Alexandria University |
20709553 |
72 |
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
Pfizer |
21055613 |
31 |
The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate. |
Pfizer |
20728356 |
68 |
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: the three microdose candidates. |
Pfizer |
20954731 |
18 |
Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities. |
Kumamoto University |
20813948 |
63 |
Spiroindolones, a potent compound class for the treatment of malaria. |
Swiss Tropical and Public Health Institute |
20566292 |
6 |
5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration. |
Amira Pharmaceuticals |
20540535 |
48 |
Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity. |
Peking University Health Science Center |
20144869 |
90 |
Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template. |
Pfizer |
20056549 |
12 |
Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production. |
National Taiwan University |
19957931 |
66 |
Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation. |
Sapienza University of Rome |
19540763 |
4 |
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. |
University of Arizona |
19527929 |
1 |
Design, synthesis and evaluation of aspirin analogues having an additional carboxylate substituent for antithrombotic activity. |
Royal College of Surgeons In Ireland |
19523822 |
33 |
Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach. |
Glaxosmithkline |
19520573 |
108 |
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors. |
Glaxosmithkline |
19739647 |
52 |
5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). |
Amira Pharmaceuticals |
19427206 |
5 |
The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives. |
Vanderbilt University School of Medicine |
19191553 |
1 |
Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. |
The Scripps Research Institute |
| 22 |
3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2 |
TBA |
| 49 |
A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles |
TBA |
| 46 |
Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors |
TBA |
| 30 |
Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors |
TBA |
| 25 |
Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors |
TBA |
| 2 |
Syntheses and biological evaluation of two new naproxen analogs |
TBA |
| 48 |
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective cox-2 inhibitors. part II: Replacing the heterocycle |
TBA |
| 20 |
Selective cyclooxygenase inhibitors: Novel 4-spiro 1,2-diarylcyclopentenes are potent and orally active cox-2 inhibitors |
TBA |
| 18 |
3,4-diarylthiophenes are selective COX-2 inhibitors |
TBA |
| 16 |
Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors |
TBA |
| 51 |
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors |
TBA |
19286379 |
8 |
Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib. |
Chinese Academy of Medical Sciences |
19157881 |
28 |
Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives. |
University of Alberta |
19135376 |
4 |
Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates. |
Universidade Federal Do Rio De Janeiro |
19056264 |
6 |
Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors. |
Institute |
19053765 |
15 |
New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. |
Martin-Luther-Universitaet |
18976930 |
10 |
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. |
National Institute of Advanced Industrial Science and Technology (Aist) |
18811132 |
1 |
Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. |
The Scripps Research Institute |
18752957 |
44 |
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. |
Sapienza University of Rome |
18667313 |
22 |
New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines. |
Université |
18650097 |
4 |
Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor. |
Institute of Radiopharmacy |
18598017 |
28 |
Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity. |
Universita Di Siena |
18487053 |
55 |
Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. |
Purdue University |
18457385 |
41 |
Recent developments in fragment-based drug discovery. |
Astex Therapeutics |
18262309 |
24 |
2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols. |
Guru Nanak Dev University |
17532544 |
10 |
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. |
University of Alexandria |
16252917 |
8 |
Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum. |
Chinese Academy of Sciences |
12444669 |
10 |
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. |
Uppsala University |
11170689 |
6 |
Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures. |
University of Illinois At Chicago |
10650073 |
2 |
Dimerization of resveratrol by the grapevine pathogen Botrytis cinerea. |
University of Louisiana At Monroe |
10075763 |
6 |
Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. |
Department of Horticulture and National Food Safety and Toxicology Center |
9544564 |
16 |
5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea. |
Heinrich-Heine-UniversitäT DüSseldorf |
18095641 |
1 |
Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. |
The Scripps Research Institute |
17915854 |
38 |
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. |
Sapienza University of Rome |
17822894 |
10 |
Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors. |
Shaheed Beheshti University of Medical Sciences |
17480099 |
14 |
Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities. |
Chiang Mai University |
17378609 |
29 |
Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. |
Tahitian Noni International |
17341061 |
21 |
Structural and functional basis of cyclooxygenase inhibition. |
Institute For Chemical Biology and Center In Molecular Toxicology |
17335184 |
26 |
NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties. |
Università |
16814546 |
41 |
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. |
National Research Institute of Chinese Medicine |
16753296 |
25 |
Discovery of potent CRTh2 (DP2) receptor antagonists. |
Astrazeneca R&D Charnwood |
16455248 |
3 |
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. |
Merck Research Laboratories |
16290144 |
17 |
Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones. |
Universidad De Santiago De Compostela |
16275073 |
16 |
Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids. |
Universidad De Santiago De Compostela |
16190777 |
6 |
Synthesis and pharmacological evaluation of 1H-imidazoles as ligands for the estrogen receptor and cytotoxic inhibitors of the cyclooxygenase. |
Free University of Berlin |
15993594 |
4 |
In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I. |
Università |
15936193 |
4 |
Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia. |
Merck Research Laboratories |
15916445 |
8 |
3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone as a potent and orally active cyclooxygenase-2 selective inhibitor: synthesis and biological evaluation. |
Nitromed |
15837305 |
4 |
Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor. |
Merck Research Laboratories |
15615524 |
58 |
Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors. |
Université |
15566290 |
60 |
New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy. |
Université |
15546727 |
6 |
3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors. |
Nitromed |
15454242 |
48 |
Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors. |
Glaxosmithkline |
15369392 |
22 |
Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. |
Università |
15324899 |
83 |
Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors. |
Roche Palo Alto |
15324885 |
56 |
Exploring QSAR with E-state index: selectivity requirements for COX-2 versus COX-1 binding of terphenyl methyl sulfones and sulfonamides. |
Jadavpur University |
15239665 |
83 |
Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors. |
RhôNe-Poulenc Rorer |
15177482 |
90 |
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis. |
Novartis Institutes For Biomedical Research |
15084117 |
10 |
Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazoles. |
Nitromed |
14980665 |
33 |
Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. |
Merck Frosst Centre For Therapeutic Research |
14640557 |
19 |
Synthesis and structure-activity relationship of novel, highly potent metharyl and methcycloalkyl cyclooxygenase-2 (COX-2) selective inhibitors. |
Nitromed |
12877584 |
182 |
Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles. |
Domp&Egrove |
12729631 |
16 |
Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors. |
Dr. Reddy'S Laboratories |
12643942 |
82 |
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility. |
Merck Frosst Centre For Therapeutic Research |
12639552 |
25 |
Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors. |
Vittal Mallya Scientific Research Foundation |
12639538 |
90 |
Pyridazinones as selective cyclooxygenase-2 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
12408728 |
6 |
Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors. |
Université |
12392741 |
7 |
Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile. |
Merck Frosst Centre For Therapeutic Research |
12217369 |
16 |
Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors. |
University of Alberta |
11906281 |
22 |
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. |
Laboratorios Menarini |
11859001 |
30 |
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor. |
Laboratoires Innothera |
11844666 |
31 |
Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. |
Laboratorios Menarini |
11738574 |
36 |
4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors. |
Central Pharmaceutical Research Institute |
11520213 |
12 |
Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere. |
University of Alberta |
11520200 |
17 |
Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity. |
University of Alberta |
32127262 |
40 |
Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. |
Assiut University |
11462976 |
20 |
Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines. |
J. Uriach & CíA. |
11412982 |
2 |
Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata. |
University of Illinois At Chicago |
11392547 |
15 |
Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors. |
Abbott Laboratories |
32551603 |
185 |
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. |
Novartis Institutes For Biomedical Research |
11327589 |
11 |
In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663). |
Merck Frosst Centre For Therapeutic Research |
11262075 |
3 |
Perspectives in animal health: old targets and new opportunities. |
Merck Research Laboratories |
11229771 |
38 |
Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship. |
Seoul National University |
11128651 |
18 |
Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx). |
Merck Frosst Centre For Therapeutic Research |
10956225 |
106 |
Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents. |
Pfizer |
10937738 |
38 |
Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors. |
University of Barcelona |
10841807 |
6 |
Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity of ketoprofen analogues. |
Laboratorios Menarini |
10794682 |
4 |
N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration. |
Pfizer |
10741562 |
60 |
1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2. |
The R. W. Johnson Pharmaceutical Research Institute |
10715145 |
9 |
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. |
Searle Research and Development |
31436984 |
54 |
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. |
Goethe-University Frankfurt |
31255927 |
34 |
Human disorders associated with inflammation and the evolving role of natural products to overcome. |
University of Delhi |
10576685 |
63 |
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
10576684 |
67 |
A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
10465547 |
24 |
SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor. |
Merck Frosst Centre For Therapeutic Research |
30928706 |
30 |
New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES. |
Cairo University |
10397507 |
42 |
2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
31160177 |
26 |
Chalcone derivatives bearing chromen or benzo[f]chromen moieties: Design, synthesis, and evaluations of anti-inflammatory, analgesic, selective COX-2 inhibitory activities. |
Zhejiang Ocean University |
31345747 |
29 |
COX-1/COX-2 inhibition activities and molecular docking study of newly designed and synthesized pyrrolo[3,4-c]pyrrole Mannich bases. |
Wroclaw Medical University |
10328307 |
24 |
Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors. |
G.D. Searle-Monsanto |
10328306 |
58 |
Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors. |
G.D. Searle-Monsanto |
10197960 |
171 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series. |
Warner-Lambert |
10197959 |
92 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series. |
Warner-Lambert |
30300845 |
43 |
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
Universit£ |
10021918 |
59 |
Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class. |
Merck Frosst Centre For Therapeutic Research |
9873621 |
48 |
2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
31185168 |
144 |
Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor. |
Rti International |
9871731 |
14 |
Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2. |
Boehringer Ingelheim Pharmaceuticals |
9871612 |
8 |
Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry. |
Abbott Laboratories |
31383589 |
6 |
Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
California Institute of Technology |
9784093 |
2 |
6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2, 3-b]pyridine (RWJ 68354): a potent and selective p38 kinase inhibitor. |
The R. W. Johnson Pharmaceutical Research Institute |
30904755 |
26 |
Synthesis and biological evaluation of pyridazinone derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents. |
Cairo University |
30877972 |
89 |
Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents. |
Nanjing University |
9719605 |
62 |
New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position. |
Procter & Gamble Pharmaceuticals |
9544212 |
37 |
New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring. |
Procter & Gamble Pharmaceuticals |
9544211 |
39 |
New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent. |
Procter & Gamble Pharmaceuticals |
31401465 |
52 |
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
Julius Maximilian University of W£Rzburg |
9171873 |
192 |
1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents. |
Searle Research and Development |
9171872 |
85 |
1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2. |
Searle Research and Development |
9135032 |
217 |
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). |
Searle Research and Development |
9083488 |
29 |
Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. |
Boehringer Ingelheim Pharmaceuticals |
9057869 |
25 |
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors. |
Abbott Laboratories |
31655429 |
42 |
Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency. |
Umm Al-Qura University |
8627608 |
100 |
Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents. |
Searle Research and Development |
8568815 |
70 |
Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships. |
Searle Research and Development |
8523403 |
50 |
Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives. |
Merck Frosst Centre For Therapeutic Research |
24602792 |
6 |
Benzimidazole: an emerging scaffold for analgesic and anti-inflammatory agents. |
Asbasjsm College of Pharmacy |
24440378 |
42 |
N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism. |
University of Li£Ge |
24531199 |
16 |
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles. |
University of Bari "A. Moro |
24373735 |
48 |
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. |
Universit£ |
24211633 |
14 |
Synthesis of novel 1,2,3-triazole based benzoxazolinones: their TNF-? based molecular docking with in-vivo anti-inflammatory, antinociceptive activities and ulcerogenic risk evaluation. |
Jamia Hamdard (Hamdard University) |
24088053 |
11 |
Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching. |
E£Tv£S Lor£Nd University |
7966148 |
40 |
Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors. |
Searle Research & Development |
23680444 |
36 |
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity. |
Universit£ |
23651359 |
56 |
Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors. |
Universit£ |
7473585 |
70 |
1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents. |
Searle Research and Development |
12542354 |
3 |
Chemical and biological investigation of the fungus Pulveroboletus ravenelii. |
The University of Mississippi |
17618015 |
13 |
Bioactive peroxides as potential therapeutic agents. |
The Hebrew University of Jerusalem |
30344915 |
45 |
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides. |
University of Cagliari |
30031652 |
62 |
Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition. |
Nanjing University |
29032033 |
8 |
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier. |
University of Bari "Aldo Moro |
29031075 |
42 |
Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities. |
Damanhour University |
30017112 |
36 |
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery. |
Abbottabad University of Science and Technology |
28720504 |
63 |
Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX. |
Nanjing University |
28475316 |
34 |
Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation. |
Guangzhou Institutes of Biomedicine and Health |
28427813 |
14 |
Novel pyrazoles and pyrazolo[1,2-a]pyridazines as selective COX-2 inhibitors; Ultrasound-assisted synthesis, biological evaluation, and DFT calculations. |
Suez Canal University |
28400234 |
66 |
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E |
Glenmark Pharmaceuticals |
26642829 |
34 |
Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects. |
Atat£Rk University |