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Compile Data Set for Download or QSAR

Found 63 hits Enz. Inhib. hit(s) with all data for entry = 3042   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389576
PNG
(N-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quinaz...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN)c3cc(Br)ccc3n2)cc1
Show InChI InChI=1S/C20H21BrN4O/c1-26-16-7-3-14(4-8-16)5-10-19-24-18-9-6-15(21)13-17(18)20(25-19)23-12-2-11-22/h3-10,13H,2,11-12,22H2,1H3,(H,23,24,25)/b10-5+
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n/an/a 74n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389583
PNG
(N-{2-[(E)-2-(4- methoxyphenyl)vinyl]quinazolin-4- ...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN)c3ccccc3n2)cc1
Show InChI InChI=1S/C20H22N4O/c1-25-16-10-7-15(8-11-16)9-12-19-23-18-6-3-2-5-17(18)20(24-19)22-14-4-13-21/h2-3,5-12H,4,13-14,21H2,1H3,(H,22,23,24)/b12-9+
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n/an/a 134n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389615
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H23ClN4O2S/c1-26(2)13-12-23-21-18-14-16(22)7-10-19(18)24-20(25-21)11-6-15-4-8-17(9-5-15)29(3,27)28/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-6+
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n/an/a 246n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389591
PNG
(N'-{2-[(E)-2-(4- isopropylphenyl)vinyl]quinazolin-...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C23H28N4/c1-17(2)19-12-9-18(10-13-19)11-14-22-25-21-8-6-5-7-20(21)23(26-22)24-15-16-27(3)4/h5-14,17H,15-16H2,1-4H3,(H,24,25,26)/b14-11+
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n/an/a 258n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389604
PNG
(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylsulfonyl)phen...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccccc12
Show InChI InChI=1S/C21H24N4O2S/c1-25(2)15-14-22-21-18-6-4-5-7-19(18)23-20(24-21)13-10-16-8-11-17(12-9-16)28(3,26)27/h4-13H,14-15H2,1-3H3,(H,22,23,24)/b13-10+
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n/an/a 326n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389608
PNG
(N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C23H27ClN4/c1-16(2)18-8-5-17(6-9-18)7-12-22-26-21-11-10-19(24)15-20(21)23(27-22)25-13-14-28(3)4/h5-12,15-16H,13-14H2,1-4H3,(H,25,26,27)/b12-7+
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n/an/a 412n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389616
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12
Show InChI InChI=1S/C23H27ClN4O2S/c1-4-28(5-2)15-14-25-23-20-16-18(24)9-12-21(20)26-22(27-23)13-8-17-6-10-19(11-7-17)31(3,29)30/h6-13,16H,4-5,14-15H2,1-3H3,(H,25,26,27)/b13-8+
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n/an/a 440n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389586
PNG
(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...)
Show SMILES CSc1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C21H24N4S/c1-25(2)15-14-22-21-18-6-4-5-7-19(18)23-20(24-21)13-10-16-8-11-17(26-3)12-9-16/h4-13H,14-15H2,1-3H3,(H,22,23,24)/b13-10+
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n/an/a 461n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389611
PNG
(N'-{6-fluoro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCN(C)C)c3cc(F)ccc3n2)cc1
Show InChI InChI=1S/C23H27FN4/c1-16(2)18-8-5-17(6-9-18)7-12-22-26-21-11-10-19(24)15-20(21)23(27-22)25-13-14-28(3)4/h5-12,15-16H,13-14H2,1-4H3,(H,25,26,27)/b12-7+
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n/an/a 582n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389574
PNG
(N'-{2-[(E)-2-(4- fluorophenyl)vinyl]quinazolin-4-y...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(F)cc2)nc2ccccc12
Show InChI InChI=1S/C20H21FN4/c1-25(2)14-13-22-20-17-5-3-4-6-18(17)23-19(24-20)12-9-15-7-10-16(21)11-8-15/h3-12H,13-14H2,1-2H3,(H,22,23,24)/b12-9+
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n/an/a 811n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389613
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12
Show InChI InChI=1S/C22H25ClN4O2S/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(10-6-16)30(3,28)29/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
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n/an/a 873n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389612
PNG
(N,N-diethyl-N'-{6-fluoro-2-[(E)-2-(4- isopropylphe...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccc(F)cc12
Show InChI InChI=1S/C25H31FN4/c1-5-30(6-2)16-15-27-25-22-17-21(26)12-13-23(22)28-24(29-25)14-9-19-7-10-20(11-8-19)18(3)4/h7-14,17-18H,5-6,15-16H2,1-4H3,(H,27,28,29)/b14-9+
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n/an/a 874n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389585
PNG
(N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]benzo[...)
Show SMILES CN(C)CCNc1nc(\C=C\c2cccs2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C22H22N4S/c1-26(2)12-11-23-22-19-14-16-6-3-4-7-17(16)15-20(19)24-21(25-22)10-9-18-8-5-13-27-18/h3-10,13-15H,11-12H2,1-2H3,(H,23,24,25)/b10-9+
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n/an/a 950n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389610
PNG
(N'-{6-fluoro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(F)ccc3n2)cc1
Show InChI InChI=1S/C24H29FN4/c1-17(2)19-9-6-18(7-10-19)8-13-23-27-22-12-11-20(25)16-21(22)24(28-23)26-14-5-15-29(3)4/h6-13,16-17H,5,14-15H2,1-4H3,(H,26,27,28)/b13-8+
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n/an/a 1.26E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389602
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylthio)phenyl]vinyl...)
Show SMILES CSc1ccc(\C=C\c2nc(NCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C21H23ClN4S/c1-26(2)13-12-23-21-18-14-16(22)7-10-19(18)24-20(25-21)11-6-15-4-8-17(27-3)9-5-15/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-6+
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n/an/a 1.26E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389606
PNG
(N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C24H29ClN4/c1-17(2)19-9-6-18(7-10-19)8-13-23-27-22-12-11-20(25)16-21(22)24(28-23)26-14-5-15-29(3)4/h6-13,16-17H,5,14-15H2,1-4H3,(H,26,27,28)/b13-8+
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n/an/a 1.27E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389559
PNG
(N'-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quina...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(Br)ccc3n2)cc1
Show InChI InChI=1S/C22H25BrN4O/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(28-3)10-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
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n/an/a 1.39E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389609
PNG
(N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccc(Cl)cc12
Show InChI InChI=1S/C25H31ClN4/c1-5-30(6-2)16-15-27-25-22-17-21(26)12-13-23(22)28-24(29-25)14-9-19-7-10-20(11-8-19)18(3)4/h7-14,17-18H,5-6,15-16H2,1-4H3,(H,27,28,29)/b14-9+
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n/an/a 1.40E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389558
PNG
(N'-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quina...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(F)ccc3n2)cc1
Show InChI InChI=1S/C22H25FN4O/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(28-3)10-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
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n/an/a 1.42E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389590
PNG
(N,N-diethyl-N'-{2-[(E)-2-(4- isopropylphenyl)vinyl...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccccc12
Show InChI InChI=1S/C26H34N4/c1-5-30(6-2)19-9-18-27-26-23-10-7-8-11-24(23)28-25(29-26)17-14-21-12-15-22(16-13-21)20(3)4/h7-8,10-17,20H,5-6,9,18-19H2,1-4H3,(H,27,28,29)/b17-14+
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n/an/a 1.51E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389603
PNG
(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylsulfonyl)phen...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccccc12
Show InChI InChI=1S/C22H26N4O2S/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(13-10-17)29(3,27)28/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25)/b14-11+
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n/an/a 1.51E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389562
PNG
(N'-{6-bromo-2-[(E)-2-(4- fluorophenyl)vinyl]quinaz...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(Br)cc12
Show InChI InChI=1S/C21H22BrFN4/c1-27(2)13-3-12-24-21-18-14-16(22)7-10-19(18)25-20(26-21)11-6-15-4-8-17(23)9-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,24,25,26)/b11-6+
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n/an/a 1.55E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389582
PNG
(N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]benzo[...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2cccs2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C23H24N4S/c1-27(2)13-6-12-24-23-20-15-17-7-3-4-8-18(17)16-21(20)25-22(26-23)11-10-19-9-5-14-28-19/h3-5,7-11,14-16H,6,12-13H2,1-2H3,(H,24,25,26)/b11-10+
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n/an/a 1.64E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389581
PNG
(N'-{6-chloro-2-[(E)-2-(3,4- difluorophenyl)vinyl]q...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C20H19ClF2N4/c1-27(2)10-9-24-20-15-12-14(21)5-7-18(15)25-19(26-20)8-4-13-3-6-16(22)17(23)11-13/h3-8,11-12H,9-10H2,1-2H3,(H,24,25,26)/b8-4+
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n/an/a 1.70E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389578
PNG
(N,N-diethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]vi...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(SC)cc2)nc2ccccc12
Show InChI InChI=1S/C23H28N4S/c1-4-27(5-2)17-16-24-23-20-8-6-7-9-21(20)25-22(26-23)15-12-18-10-13-19(28-3)14-11-18/h6-15H,4-5,16-17H2,1-3H3,(H,24,25,26)/b15-12+
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n/an/a 1.76E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389554
PNG
(N'-{6-chloro-2-[(E)-2-(4- methoxyphenyl)vinyl]quin...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C22H25ClN4O/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(28-3)10-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
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n/an/a 1.91E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389560
PNG
(N'-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quina...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(OC)cc2)nc2ccc(Br)cc12
Show InChI InChI=1S/C24H29BrN4O/c1-4-29(5-2)16-6-15-26-24-21-17-19(25)10-13-22(21)27-23(28-24)14-9-18-7-11-20(30-3)12-8-18/h7-14,17H,4-6,15-16H2,1-3H3,(H,26,27,28)/b14-9+
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n/an/a 1.96E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389614
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12
Show InChI InChI=1S/C24H29ClN4O2S/c1-4-29(5-2)16-6-15-26-24-21-17-19(25)10-13-22(21)27-23(28-24)14-9-18-7-11-20(12-8-18)32(3,30)31/h7-14,17H,4-6,15-16H2,1-3H3,(H,26,27,28)/b14-9+
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n/an/a 1.98E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389573
PNG
(N'-{6-bromo-2-[(E)-2-(3,4- difluorophenyl)vinyl]qu...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccc(Br)cc12
Show InChI InChI=1S/C20H19BrF2N4/c1-27(2)10-9-24-20-15-12-14(21)5-7-18(15)25-19(26-20)8-4-13-3-6-16(22)17(23)11-13/h3-8,11-12H,9-10H2,1-2H3,(H,24,25,26)/b8-4+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389589
PNG
(N'-{2-[(E)-2-(4- isopropylphenyl)vinyl]quinazolin-...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C24H30N4/c1-18(2)20-13-10-19(11-14-20)12-15-23-26-22-9-6-5-8-21(22)24(27-23)25-16-7-17-28(3)4/h5-6,8-15,18H,7,16-17H2,1-4H3,(H,25,26,27)/b15-12+
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n/an/a 2.02E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389575
PNG
(N,N-diethyl-N'-{2-[(E)-2-(4- fluorophenyl)vinyl]qu...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(F)cc2)nc2ccccc12
Show InChI InChI=1S/C22H25FN4/c1-3-27(4-2)16-15-24-22-19-7-5-6-8-20(19)25-21(26-22)14-11-17-9-12-18(23)13-10-17/h5-14H,3-4,15-16H2,1-2H3,(H,24,25,26)/b14-11+
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n/an/a 2.12E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389567
PNG
(N'-{6-chloro-2-[(E)-2-(4- fluorophenyl)vinyl]quina...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C23H26ClFN4/c1-3-29(4-2)15-5-14-26-23-20-16-18(24)9-12-21(20)27-22(28-23)13-8-17-6-10-19(25)11-7-17/h6-13,16H,3-5,14-15H2,1-2H3,(H,26,27,28)/b13-8+
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n/an/a 2.26E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389565
PNG
(N'-{6-bromo-2-[(E)-2-(4- fluorophenyl)vinyl]quinaz...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(Br)cc12
Show InChI InChI=1S/C23H26BrFN4/c1-3-29(4-2)15-5-14-26-23-20-16-18(24)9-12-21(20)27-22(28-23)13-8-17-6-10-19(25)11-7-17/h6-13,16H,3-5,14-15H2,1-2H3,(H,26,27,28)/b13-8+
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n/an/a 2.28E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389595
PNG
(N'-{6-chloro-2-[(E)-2-(2- thienyl)vinyl]quinazolin...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2cccs2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C20H23ClN4S/c1-3-25(4-2)12-11-22-20-17-14-15(21)7-9-18(17)23-19(24-20)10-8-16-6-5-13-26-16/h5-10,13-14H,3-4,11-12H2,1-2H3,(H,22,23,24)/b10-8+
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n/an/a 2.31E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389584
PNG
(N,N-diethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]benzo[g...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2cccs2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C25H28N4S/c1-3-29(4-2)15-8-14-26-25-22-17-19-9-5-6-10-20(19)18-23(22)27-24(28-25)13-12-21-11-7-16-30-21/h5-7,9-13,16-18H,3-4,8,14-15H2,1-2H3,(H,26,27,28)/b13-12+
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n/an/a 2.33E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389599
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylthio)phenyl]vinyl...)
Show SMILES CSc1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C22H25ClN4S/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(28-3)10-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
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n/an/a 2.39E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389566
PNG
(N'-{6-chloro-2-[(E)-2-(4- fluorophenyl)vinyl]quina...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H22ClFN4/c1-27(2)13-3-12-24-21-18-14-16(22)7-10-19(18)25-20(26-21)11-6-15-4-8-17(23)9-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,24,25,26)/b11-6+
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n/an/a 2.39E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389594
PNG
(N'-{6-chloro-2-[(E)-2-(2- thienyl)vinyl]quinazolin...)
Show SMILES CN(C)CCNc1nc(\C=C\c2cccs2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C18H19ClN4S/c1-23(2)10-9-20-18-15-12-13(19)5-7-16(15)21-17(22-18)8-6-14-4-3-11-24-14/h3-8,11-12H,9-10H2,1-2H3,(H,20,21,22)/b8-6+
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n/an/a 2.93E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389607
PNG
(N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccc(Cl)cc12
Show InChI InChI=1S/C26H33ClN4/c1-5-31(6-2)17-7-16-28-26-23-18-22(27)13-14-24(23)29-25(30-26)15-10-20-8-11-21(12-9-20)19(3)4/h8-15,18-19H,5-7,16-17H2,1-4H3,(H,28,29,30)/b15-10+
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n/an/a 2.97E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389563
PNG
(N'-{2-[(E)-2-(4- fluorophenyl)vinyl]quinazolin-4-y...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccccc12
Show InChI InChI=1S/C21H23FN4/c1-26(2)15-5-14-23-21-18-6-3-4-7-19(18)24-20(25-21)13-10-16-8-11-17(22)12-9-16/h3-4,6-13H,5,14-15H2,1-2H3,(H,23,24,25)/b13-10+
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n/an/a 3.08E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389588
PNG
(N'-{2-[(E)-2-(3,4- difluorophenyl)vinyl]quinazolin...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccccc12
Show InChI InChI=1S/C22H24F2N4/c1-3-28(4-2)14-13-25-22-17-7-5-6-8-20(17)26-21(27-22)12-10-16-9-11-18(23)19(24)15-16/h5-12,15H,3-4,13-14H2,1-2H3,(H,25,26,27)/b12-10+
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n/an/a 3.25E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389577
PNG
(N-[3-({6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]qu...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCNC(C)=O)c3cc(Br)ccc3n2)cc1
Show InChI InChI=1S/C22H23BrN4O2/c1-15(28)24-12-3-13-25-22-19-14-17(23)7-10-20(19)26-21(27-22)11-6-16-4-8-18(29-2)9-5-16/h4-11,14H,3,12-13H2,1-2H3,(H,24,28)(H,25,26,27)/b11-6+
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n/an/a 3.70E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389605
PNG
(2-{(E)-2-[4- (methylsulfonyl)phenyl]vinyl}-N- prop...)
Show SMILES CCCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccccc12
Show InChI InChI=1S/C20H21N3O2S/c1-3-14-21-20-17-6-4-5-7-18(17)22-19(23-20)13-10-15-8-11-16(12-9-15)26(2,24)25/h4-13H,3,14H2,1-2H3,(H,21,22,23)/b13-10+
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n/an/a 3.82E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389568
PNG
(N'-{6-fluoro-2-[(E)-2-(4- fluorophenyl)vinyl]quina...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(F)cc12
Show InChI InChI=1S/C21H22F2N4/c1-27(2)13-3-12-24-21-18-14-17(23)9-10-19(18)25-20(26-21)11-6-15-4-7-16(22)8-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,24,25,26)/b11-6+
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n/an/a 4.20E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389579
PNG
(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...)
Show SMILES CSc1ccc(\C=C\c2nc(NCCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C22H26N4S/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25)/b14-11+
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n/an/a 4.50E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389569
PNG
(N,N-diethyl-N'-{6-fluoro-2-[(E)-2-(4- fluorophenyl...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(F)cc12
Show InChI InChI=1S/C23H26F2N4/c1-3-29(4-2)15-5-14-26-23-20-16-19(25)11-12-21(20)27-22(28-23)13-8-17-6-9-18(24)10-7-17/h6-13,16H,3-5,14-15H2,1-2H3,(H,26,27,28)/b13-8+
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n/an/a 4.76E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389561
PNG
(N'-{2-[(E)-2-(4- methoxyphenyl)vinyl]quinazolin-4-...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C22H26N4O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25)/b14-11+
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MCE
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UniChem
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n/an/a 5.11E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389600
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylthio)phenyl]vinyl...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(SC)cc2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C24H29ClN4S/c1-4-29(5-2)16-6-15-26-24-21-17-19(25)10-13-22(21)27-23(28-24)14-9-18-7-11-20(30-3)12-8-18/h7-14,17H,4-6,15-16H2,1-3H3,(H,26,27,28)/b14-9+
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n/an/a 5.62E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389598
PNG
(N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]quinaz...)
Show SMILES CN(C)CCNc1nc(\C=C\c2cccs2)nc2ccccc12
Show InChI InChI=1S/C18H20N4S/c1-22(2)12-11-19-18-15-7-3-4-8-16(15)20-17(21-18)10-9-14-6-5-13-23-14/h3-10,13H,11-12H2,1-2H3,(H,19,20,21)/b10-9+
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n/an/a 6.29E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM389580
PNG
(N'-{6-chloro-2-[(E)-2-(3,4- difluorophenyl)vinyl]q...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H21ClF2N4/c1-28(2)11-3-10-25-21-16-13-15(22)6-8-19(16)26-20(27-21)9-5-14-4-7-17(23)18(24)12-14/h4-9,12-13H,3,10-11H2,1-2H3,(H,25,26,27)/b9-5+
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n/an/a 6.32E+3n/an/an/an/an/an/a



Georgia Institute of Technology



Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...

J Med Chem 52: 456-68 (2009)


BindingDB Entry DOI: 10.7270/Q2NG4T0S
More data for this
Ligand-Target Pair
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