286 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28621538	63	Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.	Novartis Pharma
28089698	10	Novel 2,4-dichlorophenoxy acetic acid substituted thiazolidin-4-ones as anti-inflammatory agents: Design, synthesis and biological screening.	Jamia Hamdard (Hamdard University)
27894044	37	An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold.	University of Kwazulu-Natal
1995900	4	Romazarit: a potential disease-modifying antirheumatic drug.	Roche Products
2491889	1	Antiinflammatory 2,6-di-tert-butyl-4-(2-arylethenyl)phenols.	Boehringer Ingelheim Pharmaceuticals
3104589	2	Benzimidazole derivatives with atypical antiinflammatory activity.	TBA
27597418	16	Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.	Bhupat and Jyoti Mehta School of Biosciences
27842798	66	Synthesis, COX-1/2 inhibition activities and molecular docking study of isothiazolopyridine derivatives.	Wroclaw Medical University
27349331	42	Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis.	Nanjing University
27046190	10	Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design.	Tu Dortmund University
26372652	21	Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.	Rwth Aachen University
26123643	90	Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase.	University of Jena
26048794	22	Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2.	Bangalore University
25768707	17	General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.	Universit£
25866240	56	Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors.	The First Affiliated Hospital of Nanjing Medical University
24934992	50	Novel pyrazoline derivatives as bi-inhibitor of COX-2 and B-Raf in treating cervical carcinoma.	Second Affiliated Hospital of Southeast University
25453800	3	Synthesis and PGE2 production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells.	TBA
25442305	4	Bioactive compounds from the insect Aspongopus chinensis.	Chinese Academy of Sciences
25408841	108	Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.	Vanderbilt University School of Medicine
25313331	34	Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties.	Institutes of Biomedicine and Health
24920381	77	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.	University Jena
24836072	38	Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression.	Jamia Hamdard (Hamdard University)
23473947	28	Synthesis, cyclooxygenase inhibitory effects, and molecular modeling study of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and -2-alkylsulfonyl-1H-imidazole derivatives.	Tehran University of Medical Sciences
23534442	32	Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.	Universit£
23454516	92	Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.	University of Auckland
23353741	117	Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents.	Hefei University of Technology
23432095	160	Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17ß-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.	Vanderbilt University School of Medicine
15603946	67	QSAR studies on structurally similar 2-(4-methanesulfonylphenyl)pyran-4-ones as selective COX-2 inhibitors: a Hansch approach.	Devi Ahilya Vishwavidyalaya
14552773	59	Exploring selectivity requirements for COX-2 versus COX-1 binding of 3,4-diaryloxazolones using E-state index.	Jadavpur University
23146282	3	Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones.	Devi Ahilya Vishwavidyalaya
21413808	170	Synopsis of some recent tactical application of bioisosteres in drug design.	Bristol-Myers Squibb Pharmaceutical Research and Development
22652053	6	Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins.	Rwth Aachen University
23062711	42	Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors.	Nanjing University
24900267	9	Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable ¿-Secretase Modulator.	TBA
22404396	16	Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity.	Keio University
22263894	23	Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.	Vanderbilt Institute of Chemical Biology
22236250	16	Exploring activity cliffs in medicinal chemistry.	Rheinische Friedrich-Wilhelms-Universit£T
22507964	17	Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.	Perelman School of Medicine University of Pennsylvania
22469703	32	Isoquinoline derivatives as potent CRTH2 receptor antagonists: synthesis and SAR.	Taisho Pharmaceutical
22386242	13	N-Caffeoyl serotonin as selective COX-2 inhibitor.	Kinki University
20576329	14	3-Formylchromones: potential antiinflammatory agents.	University of Karachi
20451397	55	Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines.	Universit£
19791801	86	Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors.	University of Liege
11858749	32	Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.	University of Illinois At Chicago
9784154	12	Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis.	Uppsala University
16038536	88	Expanding the ChemGPS chemical space with natural products.	Uppsala University
18363350	60	Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.	Okayama University Graduate School of Medicine
18077363	314	A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.	University of Oxford
18191402	4	Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems.	University of Sciences and Technology Houari Boum£Di£Ne
18063374	68	Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides.	Taipei Medical University
17994684	48	Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.	Nitromed
17517512	33	Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system.	Universitat De Barcelona
17346963	12	Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).	Institute For Natural Product Research and Infection Biology
16220969	219	Designed multiple ligands. An emerging drug discovery paradigm.	Organon Laboratories
12672248	50	Kinase inhibitors: not just for kinases anymore.	Northwestern University
11906292	32	4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1).	Central Pharmaceutical Research Institute
11101350	72	1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite.	Institut De Recherche Servier
10649977	72	Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors.	RhôNe-Poulenc Rorer
10197970	88	2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
10508425	68	Mixture-based synthetic combinatorial libraries.	Torrey Pines Institute For Molecular Studies
1635053	47	5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.	Wyeth-Ayerst Research
3918169	24	Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors.	TBA
15177483	33	SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity.	Novartis Institutes For Biomedical Research
10406640	31	The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.	Merck Frosst Centre For Therapeutic Research
	6	The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries	TBA
22373734	42	Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug.	Pfizer
21602044	6	Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo.	Shanghai Haini Pharmaceutical
24900317	11	Indomethacin Analogues that Enhance Doxorubicin Cytotoxicity in Multidrug Resistant Cells without Cox Inhibitory Activity.	TBA
22189137	2	Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation.	University of Genoa
21992176	52	Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.	Sapienza University of Rome
22059882	206	5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.	Amira Pharmaceuticals
22000948	50	Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors.	Nanjing University
21958738	6	Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.	Universiti Putra Malaysia
21868137	69	Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.	Gazi University
21752640	6	Bioactive sulfoximines: syntheses and properties of Vioxx analogs.	Rwth Aachen University
21570308	55	Synthesis and biological evaluation of loxoprofen derivatives.	Kumamoto University
21542630	135	Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase.	Peking University
21345672	28	Synthesis, biological evaluation and molecular docking studies of stellatin derivatives as cyclooxygenase (COX-1, COX-2) inhibitors and anti-inflammatory agents.	National Institute of Pharmaceutical Education and Research (NIPER)
21215625	40	Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors.	Pfizer
21211969	42	Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.	Amira Pharmaceuticals
21106277	1	Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.	Aristotelian University of Thessaloniki
20970223	10	Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents.	Alexandria University
20709553	72	The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life.	Pfizer
21055613	31	The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate.	Pfizer
20728356	68	The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: the three microdose candidates.	Pfizer
20954731	18	Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities.	Kumamoto University
20813948	63	Spiroindolones, a potent compound class for the treatment of malaria.	Swiss Tropical and Public Health Institute
20566292	6	5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.	Amira Pharmaceuticals
20540535	48	Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity.	Peking University Health Science Center
20144869	90	Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template.	Pfizer
20056549	12	Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.	National Taiwan University
19957931	66	Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.	Sapienza University of Rome
19540763	4	Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.	University of Arizona
19527929	1	Design, synthesis and evaluation of aspirin analogues having an additional carboxylate substituent for antithrombotic activity.	Royal College of Surgeons In Ireland
19523822	33	Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.	Glaxosmithkline
19520573	108	Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.	Glaxosmithkline
19739647	52	5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).	Amira Pharmaceuticals
19427206	5	The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives.	Vanderbilt University School of Medicine
19191553	1	Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.	The Scripps Research Institute
	22	3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2	TBA
	49	A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles	TBA
	46	Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors	TBA
	30	Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors	TBA
	25	Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors	TBA
	2	Syntheses and biological evaluation of two new naproxen analogs	TBA
	48	Synthesis and biological evaluation of 2,3-diarylthiophenes as selective cox-2 inhibitors. part II: Replacing the heterocycle	TBA
	20	Selective cyclooxygenase inhibitors: Novel 4-spiro 1,2-diarylcyclopentenes are potent and orally active cox-2 inhibitors	TBA
	18	3,4-diarylthiophenes are selective COX-2 inhibitors	TBA
	16	Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors	TBA
	51	Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors	TBA
	21	1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitor	TBA
19286379	8	Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.	Chinese Academy of Medical Sciences
19157881	28	Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives.	University of Alberta
19135376	4	Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.	Universidade Federal Do Rio De Janeiro
19056264	6	Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors.	Institute
19053765	15	New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide.	Martin-Luther-Universitaet
18976930	10	Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.	National Institute of Advanced Industrial Science and Technology (Aist)
18811132	1	Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.	The Scripps Research Institute
18752957	44	Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.	Sapienza University of Rome
18667313	22	New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines.	Université
18650097	4	Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor.	Institute of Radiopharmacy
18598017	28	Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.	Universita Di Siena
18487053	55	Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB.	Purdue University
18457385	41	Recent developments in fragment-based drug discovery.	Astex Therapeutics
18262309	24	2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols.	Guru Nanak Dev University
17532544	10	Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.	University of Alexandria
16252917	8	Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum.	Chinese Academy of Sciences
12444669	10	Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.	Uppsala University
11170689	6	Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures.	University of Illinois At Chicago
10650073	2	Dimerization of resveratrol by the grapevine pathogen Botrytis cinerea.	University of Louisiana At Monroe
10075763	6	Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries.	Department of Horticulture and National Food Safety and Toxicology Center
9544564	16	5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea.	Heinrich-Heine-UniversitäT DüSseldorf
18095641	1	Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.	The Scripps Research Institute
17915854	38	Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.	Sapienza University of Rome
17822894	10	Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.	Shaheed Beheshti University of Medical Sciences
17480099	14	Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities.	Chiang Mai University
17378609	29	Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.	Tahitian Noni International
17341061	21	Structural and functional basis of cyclooxygenase inhibition.	Institute For Chemical Biology and Center In Molecular Toxicology
17335184	26	NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties.	Università
16814546	41	Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.	National Research Institute of Chinese Medicine
16753296	25	Discovery of potent CRTh2 (DP2) receptor antagonists.	Astrazeneca R&D Charnwood
16455248	3	The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.	Merck Research Laboratories
16290144	17	Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.	Universidad De Santiago De Compostela
16275073	16	Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids.	Universidad De Santiago De Compostela
16190777	6	Synthesis and pharmacological evaluation of 1H-imidazoles as ligands for the estrogen receptor and cytotoxic inhibitors of the cyclooxygenase.	Free University of Berlin
15993594	4	In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I.	Università
15936193	4	Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia.	Merck Research Laboratories
15916445	8	3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone as a potent and orally active cyclooxygenase-2 selective inhibitor: synthesis and biological evaluation.	Nitromed
15837305	4	Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.	Merck Research Laboratories
15615524	58	Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.	Université
15566290	60	New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.	Université
15546727	6	3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.	Nitromed
15454242	48	Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.	Glaxosmithkline
15369392	22	Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal.	Università
15324899	83	Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors.	Roche Palo Alto
15324885	56	Exploring QSAR with E-state index: selectivity requirements for COX-2 versus COX-1 binding of terphenyl methyl sulfones and sulfonamides.	Jadavpur University
15239665	83	Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors.	RhôNe-Poulenc Rorer
15177482	90	Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.	Novartis Institutes For Biomedical Research
15084117	10	Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazoles.	Nitromed
14980665	33	Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.	Merck Frosst Centre For Therapeutic Research
14640557	19	Synthesis and structure-activity relationship of novel, highly potent metharyl and methcycloalkyl cyclooxygenase-2 (COX-2) selective inhibitors.	Nitromed
12877584	182	Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.	Domp&Egrove
12729631	16	Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors.	Dr. Reddy'S Laboratories
12643942	82	3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.	Merck Frosst Centre For Therapeutic Research
12639552	25	Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors.	Vittal Mallya Scientific Research Foundation
12639538	90	Pyridazinones as selective cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
12408728	6	Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.	Université
12392741	7	Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.	Merck Frosst Centre For Therapeutic Research
12217369	16	Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors.	University of Alberta
11906281	22	Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.	Laboratorios Menarini
11859001	30	Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.	Laboratoires Innothera
11844666	31	Structure-based design of cyclooxygenase-2 selectivity into ketoprofen.	Laboratorios Menarini
11738574	36	4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.	Central Pharmaceutical Research Institute
11520213	12	Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere.	University of Alberta
11520200	17	Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity.	University of Alberta
32127262	40	Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.	Assiut University
11462976	20	Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.	J. Uriach & CíA.
11412982	2	Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata.	University of Illinois At Chicago
11392547	15	Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.	Abbott Laboratories
32551603	185	Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.	Novartis Institutes For Biomedical Research
11327589	11	In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).	Merck Frosst Centre For Therapeutic Research
11262075	3	Perspectives in animal health: old targets and new opportunities.	Merck Research Laboratories
11229771	38	Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship.	Seoul National University
32142276	2	Distribution of Bibenzyls, Prenyl Bibenzyls, Bis-bibenzyls, and Terpenoids in the Liverwort Genus	Tokushima Bunri University
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10956225	106	Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.	Pfizer
10937738	38	Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors.	University of Barcelona
10841807	6	Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity of ketoprofen analogues.	Laboratorios Menarini
10794682	4	N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.	Pfizer
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10715145	9	4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.	Searle Research and Development
31436984	54	Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.	Goethe-University Frankfurt
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10576685	63	Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
10576684	67	A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
10465547	24	SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.	Merck Frosst Centre For Therapeutic Research
30928706	30	New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES.	Cairo University
10397507	42	2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
31160177	26	Chalcone derivatives bearing chromen or benzo[f]chromen moieties: Design, synthesis, and evaluations of anti-inflammatory, analgesic, selective COX-2 inhibitory activities.	Zhejiang Ocean University
31345747	29	COX-1/COX-2 inhibition activities and molecular docking study of newly designed and synthesized pyrrolo[3,4-c]pyrrole Mannich bases.	Wroclaw Medical University
10328307	24	Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors.	G.D. Searle-Monsanto
10328306	58	Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors.	G.D. Searle-Monsanto
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10197959	92	Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.	Warner-Lambert
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10021918	59	Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.	Merck Frosst Centre For Therapeutic Research
9873621	48	2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
31185168	144	Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.	Rti International
9871731	14	Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2.	Boehringer Ingelheim Pharmaceuticals
9871612	8	Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.	Abbott Laboratories
31383589	6	Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity.	California Institute of Technology
9784093	2	6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2, 3-b]pyridine (RWJ 68354): a potent and selective p38 kinase inhibitor.	The R. W. Johnson Pharmaceutical Research Institute
30904755	26	Synthesis and biological evaluation of pyridazinone derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents.	Cairo University
30877972	89	Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents.	Nanjing University
9719605	62	New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.	Procter & Gamble Pharmaceuticals
9544212	37	New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.	Procter & Gamble Pharmaceuticals
9544211	39	New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent.	Procter & Gamble Pharmaceuticals
31401465	52	Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.	Julius Maximilian University of W£Rzburg
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9083488	29	Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.	Boehringer Ingelheim Pharmaceuticals
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31655429	42	Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency.	Umm Al-Qura University
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23680444	36	A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.	Universit£
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3669017	8	Phenylephrine derivatives as leukotriene D4 antagonists.	Wyeth Laboratories
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3346867	6	Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.	Wellcome Research Laboratories
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