130 articles for thisTarget

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PMID	Data	Article Title	Organization
27282741	15	New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation.	Alexandru Ioan Cuza University
26774924	22	Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.	Cnrs Upr2301
25453818	21	Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase.	Alexandru Ioan Cuza University
15267228	20	Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1.	Leiden University
15780629	38	Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.	Bristol-Myers Squibb Pharmaceutical Research Institute
15341963	1	Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate.	University of Kentucky
15055985	22	Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?	Merck Research Laboratories
12825937	63	Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.	Merck Research Laboratories
11784157	14	Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.	Universit£
10508429	14	Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation.	Parke-Davis Pharmaceutical Research
10464022	25	Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase.	Merck Research Laboratories
9804689	40	Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase.	Merck Research Laboratories
9651171	29	N-Arylalkyl pseudopeptide inhibitors of farnesyltransferase.	Merck Research Laboratories
9622548	8	Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.	3-Dimensional Pharmaceuticals
9003517	63	Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase.	Warner-Lambert
9301658	53	Ras farnesyltransferase: a new therapeutic target.	Warner-Lambert
8568811	22	Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.	University of Pittsburgh
11755366	24	Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase.	University College London
11992789	2	Aromatic farnesyl diphosphate analogues: vinyl triflate-mediated synthesis and preliminary enzymatic evaluation.	Wayne State University
11294379	63	2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.	Merck Research Laboratories
10937743	10	Grignard-mediated synthesis and preliminary biological evaluation of novel 3-substituted farnesyl diphosphate analogues.	Wayne State University
9873725	28	Potent, non-thiol inhibitors of farnesyltransferase.	Merck Research Laboratories
	7	Peptidomimetic inhibitors of p21ras farnesyltransferase: Hydrophobic functionalization leads to disruption of p21ras membrane association in whole cells	TBA
20822181	189	Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.	Yale University
	2	Sch 207278: a novel farnesyl protein transferase inhibitor from an unidentified fungus	TBA
	10	Synthesis of triphosphonate analogues of farnesyl pyrophosphate. Inhibitors of squalene synthase and protein:farnesyl transferase	TBA
	3	A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli	TBA
	32	Novel tricyclic aminoacetyl and sulfonamide inhibitors of Ras farnesyl protein transferase	TBA
	4	Oreganic acid: a potent novel inhibitor of ras farnesyl-protein transferase from an endophytic fungus	TBA
	23	Local constrained shifty pseudopeptides inhibitors of rasfarnesyl transferase	TBA
	51	Cysteine and methionine linked by carbon pseudopeptides inhibit farnesyl transferase	TBA
	14	Rational design of potent carboxylic acid based bisubstrate inhibitors of ras farnesyl protein transferase	TBA
16442288	30	Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase.	Keimyung University
16298128	4	Enhanced FTase activity achieved via piperazine interaction with catalytic zinc.	Schering-Plough Research Institute
16289818	90	Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc.	Pharmacopeia
16216509	18	Novel triazole based inhibitors of Ras farnesyl transferase.	Janssen Research Foundation
16202593	8	Surfing the piperazine core of tricyclic farnesyltransferase inhibitors.	Pharmacopeia
15745827	10	Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I.	Janssen Research Foundation
15582430	123	Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.	Abbott Laboratories
15501065	6	Bridgehead modification of trihalocycloheptabenzopyridine leads to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability.	Schering-Plough Research Institute
15380198	46	Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.	Abbott Laboratories
14741286	31	Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors.	Institut De Recherches Servier
14741259	62	Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.	Merck Research Laboratories
14711313	8	Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.	Yale University
14643335	12	Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.	Università
14643327	17	Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.	Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd)
14643326	10	4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.	Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd)
14592494	123	Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.	Abbott Laboratories
14552788	36	Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor.	Abbott Laboratories
14552752	16	Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.	Imperial College
12852971	8	Improvement of biological activity and proteolytic stability of peptides by coupling with a cyclic peptide.	Kyowa Hakko Kogyo
12749902	5	Antifungal activity of a Candida albicans GGTase I inhibitor-alanine conjugate. Inhibition of Rho1p prenylation in C. albicans.	Gpc Biotech
12699751	18	5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.	Johnson & Johnson Pharmaceutical Research & Development
12699746	7	A novel metal-chelating inhibitor of protein farnesyltransferase.	Kumamoto University
12668012	15	From pure FPP to mixed FPP and CAAX competitive inhibitors of farnesyl protein transferase.	Centre De Recherche Pierre Fabre
12657283	37	Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.	Abbott Laboratories
12657267	65	Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.	Abbott Laboratories
12190309	14	Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.	Schering-Plough Research Institute
12113834	64	The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.	Merck Research Laboratories
11965368	64	Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.	Merck Research Laboratories
11844687	11	A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor.	Banyu Tsukuba Research Institute
11844681	45	Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.	Schering-Plough Research Institute
11754590	53	Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.	Yale University
11714612	19	A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase).	Lgci
11677136	13	3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors.	Lgci
11520202	130	Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.	Merck Research Laboratories
11459639	74	Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.	Merck Research Laboratories
11392531	79	Diaryl ether inhibitors of farnesyl-protein transferase.	Merck Research Laboratories
11378366	40	Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.	Merck Research Laboratories
11277514	23	Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.	Yale University
11229765	16	Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.	Merck Research Laboratories
11212127	7	Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1.	Philipps-UniversitäT Marburg
11020273	33	Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.	Bristol-Myers Squibb Pharmaceutical Research Institute
10794697	13	Multivariate data analysis using D-optimal designs, partial least squares, and response surface modeling: A directional approach for the analysis of farnesyltransferase inhibitors.	RhôNe-Poulenc Rorer
10698452	7	3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors.	Bristol-Myers Squibb Pharmaceutical Research Institute
10612589	22	Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase.	Merck Research Laboratories
10602709	43	Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase.	Bristol-Myers Squibb Pharmaceutical Research Institute
10508426	13	N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.	Merck Research Laboratories
10450968	22	Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.	Merck Research Laboratories
10411485	46	Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities.	Schering-Plough Research Institute
10406658	7	Analogs of 4-(3-bromo-8-methyl-10-methoxy-6,11-dihydro-5H-benzo[5,6]-cyclo hepta[1,2-b]pyridin-11-yl)-1-(4-pyridinylacetyl)piperidine N-oxide as inhibitors of farnesyl protein transferase.	Schering-Plough Research Institute
10377218	13	Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships.	Schering-Plough Research Institute
10328287	46	Potent and orally bioavailable noncysteine-containing inhibitors of protein farnesyltransferase.	Abbott Laboratories
10212118	44	Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.	Yale University
10201832	34	Potent inhibitors of protein farnesyltransferase: heteroarenes as cysteine replacements.	Abbott Laboratories
30469042	9	Pharmaceutical significance of azepane based motifs for drug discovery: A critical review.	Wuhan Institute of Technology
9873573	35	Inhibitors of farnesyl protein transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11-dihydro[1]benzthiepin, benzoxepin, and benzazepin [4,3-b]pyridine ring system.	Schering-Plough Research Institute
9873488	4	Kampanols: novel Ras farnesyl-protein transferase inhibitors from Stachybotrys kampalensis.	Merck Research Laboratories
9572881	4	Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity.	Schering-Plough Research Institute
30954427	5	Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives.	Yonsei University
9526562	257	Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine.	Schering-Plough Research Institute
9435898	32	Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.	Schering-Plough Research Institute
9406600	102	Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods.	Schering-Plough Research Institute
30366253	11	Naphthalene, a versatile platform in medicinal chemistry: Sky-high perspective.	Indian Institute of Technology (Bhu)
9191950	20	Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase.	Centre De Recherches De Vitry-Alfortville
8691464	9	Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins.	Università
8691462	14	2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.	Merck Research Laboratories
8568812	36	Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.	Bristol-Myers Squibb Pharmaceutical Research Institute
8558502	17	Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.	Bristol-Myers Squibb Pharmaceutical Research Institute
26372651	8	Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.	Alexandru Ioan Cuza University
24821376	2	Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds.	Universit£
25530833	30	Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.	University of Minnesota
24462667	28	New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents.	Merck Research Laboratories
24054122	26	Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors.	'Al. I. Cuza' University of Iasi
23880542	4	Neuroactive diol and acyloin metabolites from cone snail-associated bacteria.	University of Utah
23107667	5	Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors.	Osaka University
23207411	18	Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors.	Al. I. Cuza University of Iasi
23036952	4	Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors.	'Al. I. Cuza' University of Iasi
22738631	6	New farnesyltransferase inhibitors in the phenothiazine series.	Al. I. Cuza University of Iasi
21306898	13	Synthesis and anti-migrative evaluation of moverastin derivatives.	Keio University
20036564	27	Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues.	Centre De Recherche De Gif-Sur-Yvette
19217288	30	Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors.	Chugai Pharmaceutical
7561907	1	Barceloneic acid A, a new farnesyl-protein transferase inhibitor from a Phoma species.	Merck Research Laboratories
17827015	9	Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors.	Universit£
17722901	19	Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.	University of Washington
17555307	3	Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as farnesyltransferase inhibitors.	Purdue University
16455255	42	3D-QSAR studies of farnesyltransferase inhibitors: a comparative molecular field analysis approach.	The M.S. University of Baroda
29456111	1	Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells.	Korea University of Science and Technology
28505447	30	Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.	Temple University
22233543	70	New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis.	Centre De Recherche De Gif
19246009	10	Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.	Duke University Medical Center
11196150	3	Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.	Janssen Research Foundation
16517596	2	A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.	Duke University Medical Center
9822558	25	(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.	Schering-Plough Research Institute
12036349	58	3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.	Merck Research Laboratories