The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28318942 |
10 |
Cyclic mu-opioid receptor ligands containing multiple N-methylated amino acid residues. |
Medical University of Lodz |
| 27721146 |
22 |
(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/s |
University of Catania |
| 28435535 |
8 |
Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge. |
Universit£ |
| 2153204 |
6 |
Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules. |
Creighton University |
| 2709383 |
39 |
Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines. |
Anaquest Pharmaceuticals |
| 2536439 |
10 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist. |
University of Innsbruck |
| 3039139 |
3 |
X-ray crystal structure of the opioid ligand naltrexonazine. |
TBA |
| 3012085 |
3 |
Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity. |
TBA |
| 3009813 |
3 |
Probes for narcotic receptor mediated phenomena. 9. Synthesis of (+/-)-(3 alpha,6a alpha,11a beta)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a- methanobenzofuro[2,3-c]azocin-10-ol, an oxide-bridged 5-(m-hydroxyphenyl)morphan. |
TBA |
| 3023609 |
14 |
Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology. |
TBA |
| 2876106 |
6 |
3,7-Diazabicyclane: a new narcotic analgesic. |
TBA |
| 3020246 |
11 |
Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine. |
TBA |
| 2863378 |
7 |
Acylmorphinans. A novel class of potent analgesic agents. |
TBA |
| 2409280 |
35 |
Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone. |
TBA |
| 2999399 |
4 |
Novel nonnarcotic analgesics with an improved therapeutic ratio. Structure-activity relationships of 8-(methylthio)- and 8-(acylthio)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines. |
TBA |
| 6094809 |
32 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones. |
TBA |
| 6315939 |
2 |
14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone. |
TBA |
| 6600791 |
32 |
Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties. |
TBA |
| 6288945 |
28 |
Potential affinity labels for the opiate receptor based on fentanyl and related compounds. |
TBA |
| 6276546 |
12 |
Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone. |
TBA |
| 6268789 |
22 |
Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. |
TBA |
| 6268786 |
27 |
Opiate receptor interaction of compounds derived from or structurally related to fentanyl. |
TBA |
| 6273560 |
16 |
Preparation and analgesic properties of amino acid derivatives of (-)-5,9 alpha-diethyl-2'-hydroxybenzomorphan. |
TBA |
| 6249930 |
7 |
Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo[3.2.1]octanes. |
TBA |
| 6248644 |
4 |
Some spiro analogues of the potent analgesic ketobemidone. |
TBA |
| 28105278 |
10 |
Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds. |
Mossakowski Medical Research Centre Polish Academy of Sciences |
| 27676089 |
35 |
A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinityµ Opioid Receptor Antagonists. |
Clinical Research Institute of Montreal |
| 27301366 |
30 |
[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1. |
Nanjing Medical University |
| 27148755 |
75 |
Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacyµ-Opioid Receptor (MOR)/d-Opioid Receptor (DOR) Ligands. |
University of Michigan |
| 27234885 |
31 |
Evaluation of N-substituent structural variations in opioid receptor profile of LP1. |
University of Catania |
| 26713106 |
59 |
Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics. |
Vrije Universiteit Brussel |
| 26713104 |
24 |
Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics. |
University of Michigan |
| 26944625 |
26 |
Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs. |
Medical University of Lodz |
| 26785295 |
35 |
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration. |
Medical University of Lodz |
| 26656913 |
85 |
Multitarget opioid ligands in pain relief: New players in an old game. |
University of Catania |
| 26789491 |
44 |
Potentµ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation. |
Torrey Pines Institute For Molecular Studies |
| 26524472 |
75 |
Further Optimization and Evaluation of Bioavailable, Mixed-Efficacyµ-Opioid Receptor (MOR) Agonists/d-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities. |
University of Michigan |
| 26411794 |
46 |
Conformationally restricted¿-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines. |
Mercachem |
| 25129170 |
20 |
'Carba'-carfentanil (trans isomer): aµ opioid receptor (MOR) partial agonist with a distinct binding mode. |
Clinical Research Institute of Montreal |
| 25996309 |
49 |
Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities atµ (MOR),d (DOR), and¿ (KOR) Opioid Receptors. |
Torrey Pines Institute For Molecular Studies |
| 26005537 |
72 |
Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines. |
Medical University of Lodz |
| 25898137 |
61 |
C7ß-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at mu opioid receptors. |
University of Bath |
| 25559207 |
92 |
Synthesis and biological evaluations of novel endomorphin analogues containinga-hydroxy-ß-phenylalanine (AHPBA) displaying mixedµ/d opioid receptor agonist andd opioid receptor antagonist activities. |
Zhejiang University |
| 25544687 |
60 |
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics. |
Vrije Universiteit Brussel |
| 25047937 |
9 |
Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2. |
Medical University of Lodz |
| 25456075 |
16 |
Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-D-alanine. |
TBA |
| 25221662 |
24 |
Novel cyclic biphalin analogue with improved antinociceptive properties. |
Universit£ |
| 24761755 |
76 |
Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity. |
University of Bath |
| 24839540 |
26 |
In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt |
Vrije Universiteit Brussel |
| 24613457 |
64 |
Endomorphin analogues with mixedµ-opioid (MOP) receptor agonism/d-opioid (DOP) receptor antagonism and lackingß-arrestin2 recruitment activity. |
Nanjing Medical University |
| 24602401 |
40 |
[Dmt(1)]DALDA analogues with enhancedµ opioid agonist potency and with a mixedµ/¿ opioid activity profile. |
Nanjing Medical University |
| 24641190 |
16 |
Development of a bioavailableµ opioid receptor (MOPr) agonist,d opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. |
University of Michigan |
| 15743203 |
272 |
3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies. |
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms) |
| 23547584 |
19 |
Biological active analogues of the opioid peptide biphalin: mixeda/ß(3)-peptides. |
Universit£ |
| 23419026 |
40 |
Opioid peptidomimetics: leads for the design of bioavailable mixed efficacyµ opioid receptor (MOR) agonist/d opioid receptor (DOR) antagonist ligands. |
University of Michigan |
| 22325949 |
28 |
Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at thed opioid receptor. Discovery of two highly potent and selectived opioid agonists. |
Clinical Research Institute of Montreal |
| 23102273 |
60 |
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution. |
Vrije Universiteit Brussel |
| 22957923 |
20 |
The effect of Pro(2) modifications on the structural and pharmacological properties of endomorphin-2. |
Biological Research Center of The Hungarian Academy of Sciences |
| 22695132 |
56 |
Identification of a duald OR antagonist/µ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d). |
Janssen Research and Development |
| 21978284 |
42 |
Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixedµ/d opioid receptor agonistic properties. |
Vrije Universiteit Brussel |
| 22677527 |
38 |
Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors. |
University of Maryland |
| 20599386 |
46 |
Evaluation of N-substitution in 6,7-benzomorphan compounds. |
University of Catania |
| 20580236 |
60 |
Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors. |
University of Innsbruck and Center For Molecular Biosciences Innsbruck-Cmbi |
| 20218625 |
27 |
"Carba"-analogues of fentanyl are opioid receptor agonists. |
Clinical Research Institute of Montreal |
| 19595591 |
37 |
Synthesis and opioid receptor activity of indolopropellanes. |
Chinese Academy of Sciences |
| 19362480 |
22 |
Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. |
Kitasato University |
| 18403056 |
8 |
Ligand binding to nucleic acids and proteins: Does selectivity increase with strength? |
Universit£T Des Saarlandes |
| 18370374 |
12 |
Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility. |
Vrije Universiteit Brussel |
| 18311909 |
10 |
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging. |
Stanford University School of Medicine |
| 18178091 |
24 |
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). |
University of Ferrara |
| 18062664 |
13 |
Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. |
Biological Research Center of The Hungarian Academy of Sciences |
| 17659872 |
15 |
3-Hydroxy-4-methoxyindolomorphinans as delta opioid selective ligands. |
University of Maryland |
| 17395470 |
40 |
Differential receptor binding characteristics of consecutive phenylalanines in micro-opioid specific peptide ligand endomorphin-2. |
Kyushu University |
| 17267226 |
46 |
Novel piperazines: potent melanocortin-4 receptor antagonists with anxiolytic-like activity. |
Taisho Pharmaceutical |
| 16942034 |
19 |
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. |
University of Cagliari |
| 15857143 |
48 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
Sapienza University of Rome |
| 16033285 |
24 |
Effect of a 6-cyano substituent in 14-oxygenated N-methylmorphinans on opioid receptor binding and antinociceptive potency. |
University of Innsbruck |
| 14998329 |
142 |
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. |
Southern Research Institute |
| 14761209 |
15 |
Importance of phenolic address groups in opioid kappa receptor selective antagonists. |
Research Triangle Institute |
| 12699394 |
30 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships. |
University of Innsbruck |
| 12570383 |
46 |
3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors. |
Glaxosmithkline |
| 13678399 |
54 |
Peptide science: exploring the use of chemical principles and interdisciplinary collaboration for understanding life processes. |
University of Arizona |
| 12954070 |
24 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic. |
University of Innsbruck |
| 12825951 |
54 |
Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist. |
Research Triangle Institute |
| 11806723 |
20 |
Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties. |
University of Cagliary |
| 12459023 |
46 |
Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore. |
University of Cagliari |
| 12431065 |
72 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans. |
University of Innsbruck |
| 12139463 |
24 |
Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans. |
Research Triangle Institute |
| 11300879 |
77 |
Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides. |
Research Triangle Institute |
| 11689075 |
20 |
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation. |
University of Lausanne |
| 11495579 |
24 |
Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity. |
Research Triangle Institute |
| 10691681 |
17 |
Novel ligands lacking a positive charge for the delta- and mu-opioid receptors. |
Clinical Research Institute of Montr£Al |
| 11052799 |
10 |
Synthesis and evaluation of N,N-dialkyl enkephalin-based affinity labels for delta opioid receptors. |
University of Maryland |
| 10956208 |
121 |
Nonpeptide analogues of dynorphin A(1-8): design, synthesis, and pharmacological evaluation of kappa-selective agonists. |
University of Catania |
| 10229636 |
30 |
delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole. |
National Institute of Diabetes |
| 10639287 |
62 |
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 10479286 |
53 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans. |
Southern Research Institute |
| 9719602 |
24 |
3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy. |
University of Bristol |
| 9667975 |
86 |
Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety. |
Southern Research Institute |
| 9057856 |
53 |
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid r |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 9397176 |
28 |
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors. |
University of Arizona |
| 9301674 |
60 |
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity. |
University of Ferrara |
| 9288177 |
20 |
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides. |
University of Ferrara |
| 9288176 |
95 |
Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 8642567 |
64 |
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 7739013 |
26 |
Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities. |
Research Triangle Institute |
| 7739011 |
90 |
Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 8164255 |
23 |
Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects. |
Clinical Research Institute of Montreal |
| 8126697 |
30 |
Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety. |
University of Minnesota |
| 8201592 |
27 |
[L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity. |
University of Arizona |
| 8289188 |
30 |
Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors. |
University of Arizona |
| 8230106 |
16 |
TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity. |
Clinical Research Institute of Montreal |
| 1311764 |
4 |
Systemic analgesic activity and delta-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin. |
Searle Research and Development |
| 1323677 |
18 |
Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. |
G.D. Searle And |
| 1322988 |
60 |
Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 1648137 |
30 |
Topographically designed analogues of [D-Pen,D-Pen5]enkephalin. |
University of Arizona |
| 1851843 |
96 |
Synthesis and structure-activity relationships of deltorphin analogues. |
University of Ferrara |
| 1849997 |
42 |
Function of negative charge in the"address domain" of deltorphins. |
National Institute of Environmental Health Sciences |
| 2167979 |
43 |
Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor. |
Universit£ |
| 2153205 |
10 |
[D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors. |
University of Arizona |
| 2537426 |
12 |
Synthesis of highly mu and delta opioid receptor selective peptides containing a photoaffinity group. |
University of Arizona |
| 2536436 |
24 |
Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5. |
Smith Kline and French Laboratories |
| 2828622 |
71 |
Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides. |
University of Paris |
| 2845084 |
22 |
Effects of addition of a 2-methyl group to ethyl nipecotates (beta-meperidines) on receptor affinities and opiate agonist/antagonist activities. |
Sri International |
| 2888899 |
34 |
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds. |
Istituto Superiore Di Sanit£ |
| 3007760 |
93 |
N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines. |
TBA |
| 2878079 |
22 |
Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. |
TBA |
| 2999408 |
11 |
Hybromet: a ligand for purifying opioid receptors. |
TBA |
| 2999401 |
20 |
Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers. |
TBA |
| 6150112 |
24 |
Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors. |
TBA |
| 6296388 |
68 |
Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. |
TBA |
| 15115401 |
24 |
Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia. |
National Institutes of Environmental Health Sciences |
| 12565965 |
45 |
Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans. |
Southern Research Institute |
| 11425550 |
62 |
Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor. |
R. W. Johnson Pharmaceutical Research Institute |
| 10782696 |
67 |
ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones. |
F. Hoffmann-La Roche |
| 11078198 |
12 |
N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. |
University of Maryland |
| 10091684 |
10 |
The LMC delta opioid recognition pharmacophore: comparison of SNC80 and oxymorphindole. |
National Institute of Diabetes |
| 10617086 |
21 |
Delta opioid binding selectivity of 3-ether analogs of naltrindole. |
National Institute of Diabetes |
| 9871544 |
24 |
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives. |
National Institute of Diabetes |
| 9873480 |
35 |
Syntheses of potent Leu-enkephalin analogs possessing beta-hydroxy-alpha,alpha-disubstituted-alpha-amino acid and their characterization to opioid receptors. |
Institute For Bioorganic Research |
| | 17 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 14.1 14-ethoxy-5-methyl substituted indolomorphinans with opioid receptor selectivity |
TBA |
| | 51 |
EMD 61 753 as a favourable representative of structurally novel arylacetamido-type K opiate receptor agonists |
TBA |
| 22197670 |
51 |
Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists. |
Kitasato University |
| 22047797 |
16 |
Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs. |
Medical University of Lodz |
| 21870874 |
30 |
Synthesis, biological evaluation, and automated docking of constrained analogues of the opioid peptide H-Dmt-D-Ala-Phe-Gly-NH2 using the 4- or 5-methyl substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold. |
Vrije Universiteit Brussel |
| 21481987 |
27 |
Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: fine tuning of the dihedral angle of the ethylenediamine pharmacophore. |
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster |
| 21413804 |
21 |
Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist. |
Vrije Universiteit Brussel |
| 21287991 |
43 |
Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications. |
Hungarian Academy of Sciences |
| 21235243 |
35 |
Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies. |
University of Innsbruck |
| 20637637 |
46 |
Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. |
University of Cagliari |
| 20413312 |
17 |
Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans. |
University of Debrecen |
| 20137938 |
28 |
Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds. |
Vrije Universiteit Brussel |
| 20045339 |
16 |
Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2). |
University of Pavia |
| 19932964 |
26 |
Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton. |
Fudan University |
| 19621878 |
19 |
Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors. |
The University of Kansas |
| 19827750 |
39 |
Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1). |
Clinical Research Institute of Montreal |
| 19788201 |
32 |
Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties. |
University of Michigan |
| 19576786 |
129 |
Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands. |
Institute For Molecular Studies |
| 19642675 |
60 |
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore. |
University of Cagliari |
| 19560919 |
28 |
Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. |
Universit£ |
| 1317407 |
7 |
Akuammine and Dihydroakuammine, Two Indolomonoterpene Alkaloids Displaying Affinity for Opioid Receptors |
TBA |
| 15984054 |
21 |
Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by alpha-aminoxy acids. |
TBA |
| | 35 |
Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective μ-opioid analgesic |
TBA |
| | 8 |
Specific affinity labeling of μ opioid receptors in rat brain by S-activated sulfhydryldihydromorphine analogs |
TBA |
| | 16 |
Synthesis and biological properties of quaternized N-methylation analogs of D-Arg-2-dermorphin tetrapeptide |
TBA |
| | 4 |
A new approach to enhance bioavailability of biologically active peptides: conjugation of a δ opioid agonist to β-cyclodextrin |
TBA |
| | 8 |
Topographical requirements for delta opioid ligands: The synthesis and biological properties of a cyclic analogue of deltorphin I |
TBA |
| | 6 |
New potent enkephalin analogs containing trifluoromethylamino acid residues |
TBA |
| | 4 |
Dermorphin sequence with high δ-afinity by fixing the phe sidechain to trans at ξ1 |
TBA |
| 19435668 |
20 |
Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2. |
Medical University of Lodz |
| 19062273 |
41 |
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold. |
Vrije Universiteit Brussel |
| 18800771 |
26 |
Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. |
National University of Singapore |
| 18680274 |
44 |
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. |
University of Cagliari |
| 18572932 |
64 |
New endomorphin analogues containing alicyclic beta-amino acids: influence on bioactive conformation and pharmacological profile. |
Hungarian Academy of Sciences |
| 18490168 |
32 |
Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. |
Lanzhou University |
| 18468445 |
26 |
Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides. |
University of Queensland |
| 18207400 |
17 |
Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure. |
Medical University of Lodz |
| 17851080 |
6 |
A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic. |
University of Ferrara |
| 17497839 |
72 |
Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands. |
Kobe Gakuin University |
| 17339114 |
27 |
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore. |
University of Cagliari |
| 17315860 |
40 |
Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. |
Clinical Research Institute of Montreal |
| 17266203 |
29 |
Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2). |
Medical University |
| 17234422 |
118 |
Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor. |
Taisho Pharmaceutical |
| 17228874 |
18 |
Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. |
Hungarian Academy of Sciences |
| 17188879 |
16 |
Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. |
Lanzhou University |
| 17142049 |
40 |
Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists. |
Kobe Gakuin University |
| 16949282 |
12 |
Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity. |
Kobe Gakuin University |
| 16913729 |
9 |
Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists. |
National University of Singapore |
| 16759107 |
18 |
6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. |
Universidad De Santiago De Compostela |
| 16682191 |
21 |
Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4. |
Lanzhou University |
| 16483774 |
66 |
Identification of potent phenyl imidazoles as opioid receptor agonists. |
Johnson & Johnson Pharmaceutical Research & Development |
| 16366592 |
33 |
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1). |
University of Cagliari |
| 16335927 |
48 |
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. |
Kobe Gakuin University |
| 16183273 |
12 |
New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. |
Kobe Gakuin University |
| 15887972 |
8 |
A new structural motif for mu-opioid antagonists. |
Vrije Universiteit Brussel |
| 15863298 |
20 |
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides. |
University of Catania |
| 15658871 |
28 |
Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2. |
Kobe Gakuin University |
| 15588089 |
10 |
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic. |
University of Cagliary |
| 15456245 |
44 |
Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders. |
Johnson & Johnson Pharmaceutical Research & Development |
| 15214786 |
64 |
Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties. |
Kobe Gakuin University |
| 15163203 |
45 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 21. Novel 4-alkoxy and 14-phenylpropoxy derivatives of the mu opioid receptor antagonist cyprodime. |
University of Innsbruck |
| 14736254 |
70 |
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. |
Biological Research Center of The Hungarian Academy of Sciences |
| 12852751 |
34 |
Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia. |
Kobe Gakuin University |
| 12672238 |
3 |
Mechanism of action of the diazabicyclononanone-type kappa-agonists. |
UniversitäT WüRzburg |
| 12672226 |
9 |
A novel N-terminal cyclic dynorphin A analogue cyclo(N,5)[Trp(3),Trp(4),Glu(5)] dynorphin A-(1-11)NH(2) that lacks the basic N-terminus. |
University of Maryland |
| 12657261 |
32 |
Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities. |
Tohoku Pharmaceutical University |
| 12459018 |
6 |
Crystal structures of dipeptides containing the Dmt-Tic pharmacophore. |
National Institute of Environmental Health Sciences |
| 12372513 |
102 |
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation. |
Neurogen |
| 11958984 |
24 |
Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity. |
Tohoku Pharmaceutical University |
| 11755345 |
45 |
Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives. |
Niddk |
| 32199689 |
64 |
Design, synthesis, and biological activity of new endomorphin analogs with multi-site modifications. |
Lanzhou University |
| 32435370 |
45 |
Novel |
University of Catania |
| 11212102 |
24 |
Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4. |
Tohoku Pharmaceutical University |
| 30685525 |
34 |
Benzimidazolone-based selective ? |
University of Florida |
| 30916966 |
116 |
Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. |
TBA |
| 10956228 |
13 |
Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 10893314 |
24 |
Potent and selective indolomorphinan antagonists of the kappa-opioid receptor. |
University of Minnesota |
| 10866400 |
18 |
4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity. |
Research Triangle Institute |
| 10843229 |
92 |
Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists. |
R. W. Johnson Pharmaceutical Research Institute |
| 10841790 |
24 |
Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes. |
Istituto Di Chimica Farmaceutica E Tossicologica |
| 10753473 |
14 |
Deltorphin II analogues with 6-hydroxy-2-aminotetralin-2-carboxylic acid in position 1. |
Hungarian Academy of Sciences |
| 10691683 |
22 |
Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays. |
University of Arizona |
| 10639279 |
26 |
Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. |
The University of Arizona |
| 10585210 |
60 |
Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism. |
University of Ferrara |
| 10479285 |
17 |
The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats. |
Clinical Research Institute of Montreal |
| 30939014 |
143 |
Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety. |
Universit£T M£Nster |
| 30924650 |
73 |
Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic ?-Opioid Receptor (MOR) Agonist/?-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability. |
University of Michigan |
| 30543421 |
74 |
Development of Novel Quinoxaline-Based ?-Opioid Receptor Agonists for the Treatment of Neuroinflammation. |
Universit£T M£Nster |
| 9873693 |
24 |
N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists. |
Research Triangle Institute |
| 31220675 |
88 |
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
Biological Research Centre of The Hungarian Academy of Sciences |
| 9822547 |
41 |
De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor. |
The University of Arizona |
| 9767649 |
24 |
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists. |
Research Triangle Institute |
| 9599247 |
57 |
Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists. |
Research Triangle Institute |
| 30822708 |
24 |
(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist. |
University of Catania |
| 31498617 |
29 |
Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. |
Eisai |
| 9276018 |
47 |
Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. |
Oregon State University |
| 9258365 |
28 |
Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues. |
National Institute of Environmental Health Sciences |
| 31738550 |
78 |
Discovery of a Highly Selective and Potent ? Opioid Receptor Agonist from |
Fudan University |
| 9083489 |
30 |
Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3. |
Hungarian Academy of Sciences |
| 8576920 |
34 |
Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides. |
University of Ferrara |
| 8411007 |
392 |
Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. |
Mayo Foundation |
| 8410999 |
81 |
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
Eli Lilly |
| 207868 |
36 |
Analgesics. 1. Synthesis and analgesic properties of N-sec-alkyl- and N-tert-alkylnormorphines. |
TBA |
| 209186 |
19 |
Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin. |
TBA |
| 206698 |
2 |
Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone. |
TBA |
| 73588 |
5 |
Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics. |
TBA |
| 218015 |
16 |
Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
TBA |
| 218012 |
12 |
Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions. |
TBA |
| 109618 |
9 |
N-(2-Cyanoethyl) derivatives of meperidine, ketobemidone, and a potent 6,7-benzomorphan. |
TBA |
| 8289187 |
47 |
Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. |
University of Arizona |
| 8254604 |
50 |
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors. |
University of Ferrara |
| 8246239 |
84 |
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. |
Solvay Duphar |
| 24365161 |
45 |
Synthesis and evaluation of 4-substituted piperidines and piperazines as balanced affinity ? opioid receptor (MOR) agonist/? opioid receptor (DOR) antagonist ligands. |
University of Michigan |
| 8097539 |
10 |
Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid. |
Oregon State University |
| 23988352 |
9 |
Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity. |
Universit£ |
| 8057274 |
18 |
Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders. |
Eli Lilly |
| 23974016 |
26 |
Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation. |
Universit£ |
| 23932788 |
60 |
N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile. |
Clinical Research Institute of Montreal |
| 23822516 |
142 |
Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations. |
Universit£ |
| 7932540 |
38 |
A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 7908696 |
45 |
Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide. |
Searle |
| 7608905 |
24 |
Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 1. Conformational constraint in the"message" sequence. |
Oregon State University |
| 7562933 |
24 |
Novel deltorphin heptapeptide analogs with potent delta agonist, delta antagonist, or mixed mu antagonist/delta agonist properties. |
Tohoku College of Pharmacy |
| 7490727 |
72 |
(E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 6313921 |
10 |
Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo. |
TBA |
| 15743210 |
16 |
Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist. |
University of Bath |
| 3746815 |
15 |
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin. |
TBA |
| 29107424 |
27 |
Selective kappa opioid antagonists for treatment of addiction, are we there yet? |
University of Science and Technology |
| 30054192 |
71 |
7?-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. |
Fudan University |
| 28835802 |
12 |
Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile. |
Universit£ |
| 29273415 |
15 |
Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl). |
University of Kansas |
| 28256374 |
10 |
Original endomorphin-1 analogues exhibit good analgesic effects. |
The First Hospital of Lanzhou University |
| 2903246 |
58 |
Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors. |
University of Arizona |
| 2876099 |
51 |
Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties. |
TBA |
| 2845081 |
24 |
Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors. |
Ua 498 Cnrs |
| 30350997 |
111 |
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic ? Receptor Ligands with Exocyclic Amino Moiety. |
Universit£T M£Nster |
| 2822930 |
48 |
Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position. |
Clinical Research Institute of Montreal |
| 2542560 |
4 |
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro. |
National Institutes of Health |
| 2537427 |
24 |
Dermorphin analogues carrying an increased positive net charge in their"message" domain display extremely high mu opioid receptor selectivity. |
Clinical Research Institute of Montreal |
| 29152051 |
40 |
?-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds. |
Vrije Universiteit Brussel |
| 29853330 |
106 |
Chemical space screening around Phe |
Vrije Universiteit Brussel |
| 2153212 |
87 |
Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom. |
Merck Sharp & Dohme Research Laboratories |
| 28734666 |
23 |
Development of novel LP1-based analogues with enhanced delta opioid receptor profile. |
University of Catania |
| 28377055 |
12 |
Original endomorphin-1 analogues exhibit good analgesic effects with minimal implications for human sperm motility. |
The Reproductive Medicine Special Hospital of The First Hospital of Lanzhou University |
| 28314512 |
33 |
Modulation of opioid receptor affinity and efficacy via N-substitution of 9?-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study. |
National Institute On Drug Abuse and The National Institute On Alcohol Abuse |
| 1714957 |
12 |
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity. |
Hebrew University of Jerusalem |
| 1656045 |
26 |
Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity. |
Clinical Research Institute of Montreal |
| 1360025 |
27 |
Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity. |
Oregon State University |
| 1346276 |
25 |
Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide. |
G.D. Searle And |
| 1335080 |
20 |
Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites. |
University of Ferrara |
| 1331455 |
9 |
Delta opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives of naltrindole: evidence for delta receptor subtypes. |
University of Minnesota |
| 1331451 |
68 |
Conformationally restricted deltorphin analogues. |
Clinical Research Institute of Montreal |
| 1323682 |
61 |
Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor. |
Upjohn |
| 1320122 |
55 |
Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity. |
University of Arizona |
| 1313878 |
36 |
Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors. |
National Institute of Environmental Health Sciences |
| 27863747 |
21 |
Symmetrical aryl linked bis-iminothiazolidinones as new chemical entities for the inhibition of monoamine oxidases: Synthesis, in vitro biological evaluation and molecular modelling analysis. |
Quaid-I-Azam University |
| 27128978 |
8 |
Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening. |
Icahn School of Medicine At Mount Sinai |
| 26032047 |
15 |
Novel 4-heteroaryl-antipyrines as DPP-IV inhibitors. |
Cairo University |
| 7774675 |
35 |
Characterisation of melanocortin receptor subtypes by radioligand binding analysis. |
Uppsala |
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