The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28218838 |
69 |
Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective¿-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo. |
Dr. August Wolff Gmbh & Co. Kg Arzneimittel |
| 28011222 |
16 |
Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands. |
West Virginia University School of Pharmacy |
| 27721146 |
22 |
(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/s |
University of Catania |
| 27676089 |
35 |
A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinityµ Opioid Receptor Antagonists. |
Clinical Research Institute of Montreal |
| 27301366 |
30 |
[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1. |
Nanjing Medical University |
| 27035422 |
46 |
Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain. |
Vrije Universiteit Brussel |
| 27234885 |
31 |
Evaluation of N-substituent structural variations in opioid receptor profile of LP1. |
University of Catania |
| 26713106 |
59 |
Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics. |
Vrije Universiteit Brussel |
| 26656913 |
85 |
Multitarget opioid ligands in pain relief: New players in an old game. |
University of Catania |
| 26712115 |
36 |
Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands. |
University of Arizona |
| 26411794 |
46 |
Conformationally restricted¿-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines. |
Mercachem |
| 26323872 |
49 |
Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. |
University of Arizona |
| 26299827 |
43 |
Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. |
University of Arizona |
| 26346669 |
53 |
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain. |
University of Tsukuba |
| 25129170 |
20 |
'Carba'-carfentanil (trans isomer): aµ opioid receptor (MOR) partial agonist with a distinct binding mode. |
Clinical Research Institute of Montreal |
| 25544687 |
60 |
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics. |
Vrije Universiteit Brussel |
| 24973818 |
70 |
Pyrrolo- and pyridomorphinans: non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists. |
University of Bath |
| 25221662 |
24 |
Novel cyclic biphalin analogue with improved antinociceptive properties. |
Universit£ |
| 24761755 |
76 |
Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity. |
University of Bath |
| 24690494 |
92 |
Antagonists of the kappa opioid receptor. |
The Scripps Research Institute |
| 24839540 |
26 |
In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt |
Vrije Universiteit Brussel |
| 24613457 |
64 |
Endomorphin analogues with mixedµ-opioid (MOP) receptor agonism/d-opioid (DOP) receptor antagonism and lackingß-arrestin2 recruitment activity. |
Nanjing Medical University |
| 24602401 |
40 |
[Dmt(1)]DALDA analogues with enhancedµ opioid agonist potency and with a mixedµ/¿ opioid activity profile. |
Nanjing Medical University |
| 23477419 |
64 |
Design, synthesis, and pharmacological characterization of novel endomorphin-1 analogues as extremely potentµ-opioid agonists. |
Lanzhou University |
| 23438330 |
174 |
Orvinols with mixed kappa/mu opioid receptor agonist activity. |
University of Bath |
| 23547584 |
19 |
Biological active analogues of the opioid peptide biphalin: mixeda/ß(3)-peptides. |
Universit£ |
| 23360448 |
18 |
Development of¿ opioid receptor antagonists. |
Research Triangle Institute |
| 16290934 |
51 |
Highly potent and selective zwitterionic agonists of the delta-opioid receptor. Part 1. |
Pfizer |
| 11133082 |
32 |
Assessment of substitution in the second pharmacophore of Dmt-Tic analogues. |
University of Naples |
| 23116891 |
15 |
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons. |
Kitasato University |
| 23102273 |
60 |
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution. |
Vrije Universiteit Brussel |
| 23043264 |
20 |
Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversibleµ opioid receptor antagonist effects. |
University of Bristol |
| 22966938 |
20 |
cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2. |
Universit£ |
| 22724433 |
76 |
A new class of highly potent and selective endomorphin-1 analogues containinga-methylene-ß-aminopropanoic acids (map). |
Lanzhou University |
| 22394120 |
7 |
The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues. |
Universit£ |
| 21641798 |
16 |
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1. |
Kitasato University |
| 21128594 |
93 |
Development of potent µ and d opioid agonists with high lipophilicity. |
University of Arizona |
| 20547453 |
122 |
Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. |
University of Arizona |
| 20218625 |
27 |
"Carba"-analogues of fentanyl are opioid receptor agonists. |
Clinical Research Institute of Montreal |
| 19962305 |
2 |
Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. |
Kitasato University |
| 20560643 |
71 |
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. |
University of Arizona |
| 19349178 |
4 |
Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction. |
Kitasato University |
| 19464172 |
74 |
Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. |
Adolor |
| 19253983 |
37 |
14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. |
University of Bath |
| 18755589 |
2 |
Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction. |
Kitasato University |
| 19027293 |
149 |
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. |
Rensselaer Polytechnic Institute |
| 18637671 |
21 |
Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents. |
Toray Industries |
| 18370374 |
12 |
Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility. |
Vrije Universiteit Brussel |
| 18311909 |
10 |
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging. |
Stanford University School of Medicine |
| 18178091 |
24 |
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). |
University of Ferrara |
| 17420073 |
31 |
Synthesis of bridged piperazines with sigma receptor affinity. |
Institut F£R Pharmazeutische Und Medizinische Chemie |
| 17402725 |
9 |
Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors. |
University of Missouri-Columbia |
| 17004724 |
146 |
Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring. |
University of Bristol |
| 16942034 |
19 |
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. |
University of Cagliari |
| 16913723 |
78 |
Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones. |
University of Bristol |
| 16777416 |
80 |
Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. |
University of Kentucky |
| 16789756 |
25 |
New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. |
Vrije Universiteit Brussels |
| 16509592 |
101 |
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. |
University of Arizona |
| 15857143 |
48 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. |
Sapienza University of Rome |
| 15863299 |
8 |
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers. |
University of Arizona |
| 14998329 |
142 |
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. |
Southern Research Institute |
| 13678399 |
54 |
Peptide science: exploring the use of chemical principles and interdisciplinary collaboration for understanding life processes. |
University of Arizona |
| 12930147 |
96 |
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity. |
Universit£ |
| 12801235 |
5 |
Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. |
University of Vermont |
| 12747782 |
79 |
Structure-activity relationships of dynorphin a analogues modified in the address sequence. |
University of California |
| 12723940 |
145 |
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy. |
Research Triangle Institute |
| 12459023 |
46 |
Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore. |
University of Cagliari |
| 12431065 |
72 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans. |
University of Innsbruck |
| 11543672 |
24 |
[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists. |
Clinical Research Institute of Montreal |
| 11495592 |
12 |
Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional studies. |
Pharmazeutisches Institut Der Universit£T Freiburg |
| 11495579 |
24 |
Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity. |
Research Triangle Institute |
| 10794701 |
48 |
Structural determinants of opioid activity in the orvinols and related structures: ethers of orvinol and isoorvinol. |
University of Bristol |
| 11000010 |
27 |
Selective protection and functionalization of morphine: synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives. |
Rensselaer Polytechnic Institute |
| 10633042 |
30 |
Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. |
Harvard Medical School |
| 10229636 |
30 |
delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole. |
National Institute of Diabetes |
| 10639287 |
62 |
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 9857089 |
32 |
Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine. |
Research Triangle Institute |
| 9057861 |
33 |
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays. |
University of Washington |
| 9057856 |
53 |
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid r |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 9301674 |
60 |
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity. |
University of Ferrara |
| 8627605 |
10 |
Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide"address" recognition at kappa opioid receptors. |
University of Minnesota |
| 8648612 |
30 |
Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells. |
University of Minnesota |
| 8831778 |
22 |
The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid recepto |
University of Arizona |
| 8642567 |
64 |
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 7739011 |
90 |
Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 7853350 |
33 |
Isothiocyanate-substituted benzyl ether opioid receptor ligands derived from 6 beta-naltrexol. |
University of Washington |
| 7853332 |
27 |
7'-Substituted amino acid conjugates of naltrindole. Hydrophilic groups as determinants of selective antagonism of delta 1 opioid receptor-mediated antinociception in mice. |
University of Minnesota |
| 7636870 |
18 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-Hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. |
University of Innsbruck |
| 8164255 |
23 |
Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects. |
Clinical Research Institute of Montreal |
| 7996538 |
42 |
Synthesis and opioid receptor affinity of a series of aralkyl ethers of 6 alpha- and 6 beta-naltrexol. |
University of Washington |
| 8071934 |
30 |
Isothiocyanate-substituted kappa-selective opioid receptor ligands derived from N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl] phenylacetamide. |
University of Washington |
| 8035418 |
30 |
Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 8021929 |
13 |
Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety. |
University of Minnesota |
| 8021915 |
16 |
Newly discovered stereochemical requirements in the side-chain conformation of delta opioid agonists for recognizing opioid delta receptors. |
University of Arizona |
| 8201592 |
27 |
[L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity. |
University of Arizona |
| 8182708 |
18 |
Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor. |
University of Minnesota |
| 8289188 |
30 |
Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors. |
University of Arizona |
| 8246236 |
6 |
Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine. |
University of Minnesota |
| 8394935 |
4 |
A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
University of Minnesota |
| 8360887 |
9 |
Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity. |
University of Minnesota |
| 8380614 |
6 |
A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists. |
University of Minnesota |
| 1315870 |
39 |
Substitution on the Phe3 aromatic ring in cyclic delta opioid receptor-selective dermorphin/deltorphin tetrapeptide analogues: electronic and lipophilic requirements for receptor affinity. |
University of Michigan |
| 1361580 |
25 |
N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors. |
Oregon State University |
| 1335078 |
76 |
O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay. |
University of Washington |
| 1333014 |
12 |
Incorporation of a novel conformationally restricted tyrosine analog into a cyclic, delta opioid receptor selective tetrapeptide (JOM-13) enhances delta receptor binding affinity and selectivity. |
University of Michigan |
| 1333013 |
29 |
Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
University of Minnesota |
| 1323679 |
21 |
Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for kappa and mu opioid receptors. |
Zambeletti Research Laboratories |
| 1320121 |
48 |
Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol. |
University of Washington |
| 1319495 |
21 |
Selective reversible and irreversible ligands for the kappa opioid receptor. |
National Taiwan University |
| 1648137 |
30 |
Topographically designed analogues of [D-Pen,D-Pen5]enkephalin. |
University of Arizona |
| 1648136 |
12 |
An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists. |
University of Minnesota |
| 1851846 |
23 |
Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole. |
University of Minnesota |
| 1851843 |
96 |
Synthesis and structure-activity relationships of deltorphin analogues. |
University of Ferrara |
| 1849995 |
12 |
Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine. |
University of Minnesota |
| 1846919 |
26 |
Highly selective kappa opioid analgesics. 4. Synthesis of some conformationally restricted naphthalene derivatives with high receptor affinity and selectivity. |
Parke-Davis Research Unit |
| 2160538 |
84 |
Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. |
University of Minnesota |
| 2542556 |
65 |
Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides. |
Ciba-Geigy |
| 2832603 |
68 |
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives. |
Parke-Davis Research Unit |
| 2828622 |
71 |
Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides. |
University of Paris |
| 2887656 |
48 |
Synthesis and activity profiles of new dermorphin-(1-4) peptide analogues. |
TBA |
| 2444704 |
14 |
Hybrid bivalent ligands with opiate and enkephalin pharmacophores. |
University of Minnesota |
| 2879914 |
30 |
Peptides as receptor selectivity modulators of opiate pharmacophores. |
TBA |
| 2409281 |
9 |
10-Ketonaltrexone and 10-ketooxymorphone. |
TBA |
| 6296388 |
68 |
Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. |
TBA |
| 7154002 |
8 |
Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates and opioid peptides. |
TBA |
| 6276540 |
20 |
Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors. |
TBA |
| 15115401 |
24 |
Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia. |
National Institutes of Environmental Health Sciences |
| 12565965 |
45 |
Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans. |
Southern Research Institute |
| 11755357 |
14 |
Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity. |
University of Louisville |
| 11294396 |
57 |
Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole. |
University of Bristol |
| 11591513 |
87 |
Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. |
Harvard Medical School |
| 11425545 |
22 |
3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties. |
Pharmacia |
| 11055333 |
21 |
Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series. |
University of Bristol |
| 10673107 |
63 |
8-Aminocyclazocine analogues: synthesis and structure-activity relationships. |
Institute |
| 10206545 |
40 |
Ring constrained analogues of the orvinols: the furanomorphides. |
University of Bristol |
| 10612597 |
31 |
Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor. |
Research Triangle Institute |
| 10571174 |
25 |
(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor. |
Research Triangle Institute |
| 9873603 |
23 |
Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models. |
University of Michigan |
| 9873602 |
11 |
A high affinity, mu-opioid receptor-selective enkephalin analogue lacking an N-terminal tyrosine. |
University of Michigan |
| | 9 |
Synthesis and biological evaluation of 14-alkoxymorphinans.12.1 A phenethyl analogue of the -selective opioid receptor antagonist cyprodime |
TBA |
| | 21 |
Neurotensin receptor binding and antinociceptive activity for lipophilic N-amido neurotensin(913) analogs |
TBA |
| 21967807 |
36 |
Identification of a potent and selectives¿? receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. |
University of Pavia |
| 21925887 |
10 |
Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. |
University of Arizona |
| 21870874 |
30 |
Synthesis, biological evaluation, and automated docking of constrained analogues of the opioid peptide H-Dmt-D-Ala-Phe-Gly-NH2 using the 4- or 5-methyl substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold. |
Vrije Universiteit Brussel |
| 21641219 |
12 |
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons. |
Kitasato University |
| 21481987 |
27 |
Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: fine tuning of the dihedral angle of the ethylenediamine pharmacophore. |
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster |
| 21413804 |
21 |
Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist. |
Vrije Universiteit Brussel |
| 21366266 |
66 |
Discovery of a potent and efficacious peptide derivative ford/µ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. |
University of Arizona |
| 21256034 |
58 |
Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies. |
Kitasato University |
| 20692738 |
34 |
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. |
Sapienza University of Rome |
| 20685120 |
20 |
Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists. |
Kitasato University |
| 20637637 |
46 |
Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. |
University of Cagliari |
| 20617791 |
70 |
Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. |
University of Arizona |
| 20483601 |
22 |
Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology. |
Kitasato University |
| 20476738 |
14 |
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues. |
Universit£ |
| 20137938 |
28 |
Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds. |
Vrije Universiteit Brussel |
| 20056539 |
14 |
Investigation of Beckett-Casy model 1: synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology. |
Kitasato University |
| 20045339 |
16 |
Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2). |
University of Pavia |
| 19762245 |
69 |
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. |
University of Arizona |
| 19540763 |
4 |
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. |
University of Arizona |
| 19621878 |
19 |
Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors. |
The University of Kansas |
| 19827750 |
39 |
Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1). |
Clinical Research Institute of Montreal |
| 19642675 |
60 |
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore. |
University of Cagliari |
| 19620007 |
4 |
Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative. |
Kitasato University |
| 19560919 |
28 |
Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. |
Universit£ |
| | 12 |
The stereochemical requirements of the novel δ-opioid selective dipeptide antagonist TMT-Tic |
TBA |
| | 21 |
Arylacetamide kappa-selective opioid ligands |
TBA |
| | 26 |
6N-Cinnamoyl-β-naltrexamine and its p-nitro derivative. High efficacy κ-opioid agonists with weak antagonist actions |
TBA |
| | 24 |
Morphinan cyclic imines and pyrrolidines containing a constrained phenyl group: High affinity opioid agonists |
TBA |
| | 9 |
Octahydro-1,2,3,4,4a,5,11,11a-pyrido[3,4-c][1,5]benzoxazepines: conformationally restricted fentanyl analogs |
TBA |
| | 22 |
Palladium-catalyzed synthesis of C3-substituted 3-deoxymorphines. |
TBA |
| | 8 |
Topographical requirements for delta opioid ligands: The synthesis and biological properties of a cyclic analogue of deltorphin I |
TBA |
| 19062273 |
41 |
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold. |
Vrije Universiteit Brussel |
| 18821747 |
45 |
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. |
University of Arizona |
| 18800771 |
26 |
Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. |
National University of Singapore |
| 17851080 |
6 |
A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic. |
University of Ferrara |
| 17826995 |
48 |
Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform. |
Kobe Gakuin University |
| 17497839 |
72 |
Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands. |
Kobe Gakuin University |
| 17339114 |
27 |
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore. |
University of Cagliari |
| 17329100 |
34 |
Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. |
University of Arizona |
| 17315860 |
40 |
Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. |
Clinical Research Institute of Montreal |
| 17266203 |
29 |
Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2). |
Medical University |
| 17201419 |
93 |
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. |
University of Arizona |
| 17188879 |
16 |
Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. |
Lanzhou University |
| 17142049 |
40 |
Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists. |
Kobe Gakuin University |
| 16949282 |
12 |
Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity. |
Kobe Gakuin University |
| 16828552 |
20 |
Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. |
University of Arizona |
| 16759107 |
18 |
6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. |
Universidad De Santiago De Compostela |
| 16750366 |
104 |
Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries. |
Institute For Molecular Studies |
| 16483774 |
66 |
Identification of potent phenyl imidazoles as opioid receptor agonists. |
Johnson & Johnson Pharmaceutical Research & Development |
| 16366592 |
33 |
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1). |
University of Cagliari |
| 16335927 |
48 |
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. |
Kobe Gakuin University |
| 16275086 |
18 |
Synthesis and biological activity of the first cyclic biphalin analogues. |
University of Arizona |
| 16183273 |
12 |
New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. |
Kobe Gakuin University |
| 16107162 |
10 |
From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. |
University of Cagliari |
| 15780619 |
15 |
Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2. |
Lanzhou University |
| 15664820 |
1 |
Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3). |
Kobe Gakuin University |
| 15658871 |
28 |
Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2. |
Kobe Gakuin University |
| 15588089 |
10 |
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic. |
University of Cagliary |
| 15456245 |
44 |
Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders. |
Johnson & Johnson Pharmaceutical Research & Development |
| 15324897 |
3 |
A novel cyclic enkephalin analogue with potent opioid antagonist activity. |
Clinical Research Institute of Montreal |
| 15267245 |
10 |
Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism. |
University of Cagliary |
| 14736254 |
70 |
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. |
Biological Research Center of The Hungarian Academy of Sciences |
| 14695830 |
111 |
10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. |
Harvard Medical School |
| 12852751 |
34 |
Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia. |
Kobe Gakuin University |
| 12749896 |
47 |
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues. |
Rensselaer Polytechnic Institute |
| 12657261 |
32 |
Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities. |
Tohoku Pharmaceutical University |
| 12593663 |
146 |
Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines. |
Rensselaer Polytechnic Institute |
| 12166947 |
30 |
Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands. |
University of California |
| 11958984 |
24 |
Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity. |
Tohoku Pharmaceutical University |
| 11755345 |
45 |
Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives. |
Niddk |
| 11266156 |
42 |
8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines. |
Rensselaer Polytechnic Institute |
| 11212102 |
24 |
Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4. |
Tohoku Pharmaceutical University |
| 10753473 |
14 |
Deltorphin II analogues with 6-hydroxy-2-aminotetralin-2-carboxylic acid in position 1. |
Hungarian Academy of Sciences |
| 10639279 |
26 |
Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. |
The University of Arizona |
| 10617088 |
15 |
Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA. |
University of Louisville |
| 31550662 |
109 |
Progress in the development of more effective and safer analgesics for pain management. |
University of Catania |
| 30939014 |
143 |
Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety. |
Universit£T M£Nster |
| 30924650 |
73 |
Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic ?-Opioid Receptor (MOR) Agonist/?-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability. |
University of Michigan |
| 30543421 |
74 |
Development of Novel Quinoxaline-Based ?-Opioid Receptor Agonists for the Treatment of Neuroinflammation. |
Universit£T M£Nster |
| 9873693 |
24 |
N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists. |
Research Triangle Institute |
| 9873439 |
18 |
C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study. |
National Taiwan University |
| 9871617 |
24 |
Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide. |
University of Arizona |
| 9822547 |
41 |
De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor. |
The University of Arizona |
| 9767649 |
24 |
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists. |
Research Triangle Institute |
| 9599247 |
57 |
Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists. |
Research Triangle Institute |
| 9258365 |
28 |
Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues. |
National Institute of Environmental Health Sciences |
| 9111295 |
48 |
Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the"address" sequence. |
Oregon State University |
| 8893842 |
6 |
Aspartic acid conjugates of 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1(3-aminophenyl)-2-(1-pyrrolidi nyl) ethyl]acetamide: kappa opioid receptor agonists with limited access to the central nervous system. |
University of Minnesota |
| 8691442 |
52 |
Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency. |
University of Arizona |
| 8676350 |
39 |
Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2. |
University of Arizona |
| 26611918 |
45 |
Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations. |
University of Arizona |
| 8632410 |
33 |
Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors. |
Universitá |
| 8576920 |
34 |
Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides. |
University of Ferrara |
| 26465170 |
87 |
Discovery of Novel Multifunctional Ligands with ?/? Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. |
University of Arizona |
| 26212775 |
77 |
Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. |
University of Arizona |
| 8384662 |
20 |
A topochemical approach to explain morphiceptin bioactivity. |
University of California |
| 8289187 |
47 |
Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. |
University of Arizona |
| 8201586 |
3 |
2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
University of Minnesota |
| 24220171 |
5 |
Novel glycosylated endomorphin-2 analog produces potent centrally-mediated antinociception in mice after peripheral administration. |
Medical University of Lodz |
| 8096246 |
70 |
Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. |
University of Arizona |
| 8057274 |
18 |
Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders. |
Eli Lilly |
| 23932788 |
60 |
N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile. |
Clinical Research Institute of Montreal |
| 7996550 |
12 |
Development of a model for the delta opioid receptor pharmacophore. 2. Conformationally restricted Phe3 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). |
University of Michigan |
| 7996549 |
40 |
Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). |
University of Michigan |
| 7966152 |
57 |
Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11. |
University of Arizona |
| 24648867 |
58 |
Chiral Effect of a Phe Residue in Position 3 of the Dmt |
University of Arizona |
| 23822516 |
142 |
Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations. |
Universit£ |
| 7932535 |
40 |
Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols. |
National Taiwan University |
| 23517479 |
13 |
Orally active opioid compounds from a non-poppy source. |
Temple University |
| 23623418 |
140 |
Effect of anchoring 4-anilidopiperidines to opioid peptides. |
University of Arizona |
| 7861405 |
9 |
Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2. |
University of Arizona |
| 7799399 |
8 |
kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
University of Minnesota |
| 7731019 |
16 |
Electrophilic N-benzylnaltrindoles as delta opioid receptor-selective antagonists. |
University of Minnesota |
| 7707326 |
39 |
Opioid receptor binding requirements for the delta-selective peptide deltorphin. I: Phe3 replacement with ring-substituted and heterocyclic amino acids. |
Eastern Michigan University |
| 7658433 |
27 |
Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1. |
University of Arizona |
| 17555306 |
6 |
o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label. |
University of Minnesota |
| 6313921 |
10 |
Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo. |
TBA |
| 11960505 |
18 |
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
Chiba University |
| 29107424 |
27 |
Selective kappa opioid antagonists for treatment of addiction, are we there yet? |
University of Science and Technology |
| 29477074 |
79 |
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review. |
University of Catania |
| 3020244 |
45 |
Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors. |
TBA |
| 2876099 |
51 |
Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties. |
TBA |
| 30350997 |
111 |
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic ? Receptor Ligands with Exocyclic Amino Moiety. |
Universit£T M£Nster |
| 2822930 |
48 |
Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position. |
Clinical Research Institute of Montreal |
| 29152051 |
40 |
?-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds. |
Vrije Universiteit Brussel |
| 29853330 |
106 |
Chemical space screening around Phe |
Vrije Universiteit Brussel |
| 28734666 |
23 |
Development of novel LP1-based analogues with enhanced delta opioid receptor profile. |
University of Catania |
| 1972964 |
40 |
Design and synthesis of highly potent and selective cyclic dynorphin A analogues. |
University of Arizona |
| 1967312 |
91 |
Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogues. |
Eisai |
| 1895300 |
15 |
Modification of the enkephalin"message" with an artificial polycationic C-terminus. |
Case Western Reserve University |
| 1847432 |
13 |
New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics. |
Anaquest |
| 1846921 |
56 |
(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics. |
Zambeletti Research Laboratories |
| 1652025 |
45 |
(1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics. |
Zambeletti Research Laboratories |
| 1331451 |
68 |
Conformationally restricted deltorphin analogues. |
Clinical Research Institute of Montreal |
| 28291693 |
1 |
Synthesis and evaluation of a ligand targeting the? and? opioid receptors for drug delivery to lung cancer. |
Purdue University |
| 26496515 |
11 |
Iminothiazoline-Sulfonamide Hybrids as Jack Bean Urease Inhibitors; Synthesis, Kinetic Mechanism and Computational Molecular Modeling. |
Quaid-I-Azam University |
| 26520885 |
21 |
Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents. |
Hazara University |
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