272 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28318942	10	Cyclic mu-opioid receptor ligands containing multiple N-methylated amino acid residues.	Medical University of Lodz
28218838	69	Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective¿-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo.	Dr. August Wolff Gmbh & Co. Kg Arzneimittel
28011222	16	Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands.	West Virginia University School of Pharmacy
27721146	22	(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/s	University of Catania
27676089	35	A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinityµ Opioid Receptor Antagonists.	Clinical Research Institute of Montreal
27301366	30	[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.	Nanjing Medical University
26944625	26	Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs.	Medical University of Lodz
26785295	35	Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.	Medical University of Lodz
26789491	44	Potentµ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.	Torrey Pines Institute For Molecular Studies
26411794	46	Conformationally restricted¿-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.	Mercachem
25283554	43	Design, synthesis, and structure-activity relationship of novel opioid¿ receptor selective agonists:a-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton.	Kitasato University
25168746	28	Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin.	University of Monastir
25147605	52	Synthesis and Pharmacology of a Novel¿ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.	Kitasato University
25129170	20	'Carba'-carfentanil (trans isomer): aµ opioid receptor (MOR) partial agonist with a distinct binding mode.	Clinical Research Institute of Montreal
25996309	49	Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities atµ (MOR),d (DOR), and¿ (KOR) Opioid Receptors.	Torrey Pines Institute For Molecular Studies
26005537	72	Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.	Medical University of Lodz
25559207	92	Synthesis and biological evaluations of novel endomorphin analogues containinga-hydroxy-ß-phenylalanine (AHPBA) displaying mixedµ/d opioid receptor agonist andd opioid receptor antagonist activities.	Zhejiang University
25062506	102	Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted¿-opioid receptor agonists.	Westf£Lische Wilhelms-Universit£T M£Nster
25047937	9	Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2.	Medical University of Lodz
25456075	16	Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-D-alanine.	TBA
25248680	67	Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.	Kitasato University
24856182	23	Combination of cyclohexane and piperazine based¿-opioid receptor agonists: Synthesis and pharmacological evaluation of trans,trans-configured perhydroquinoxalines.	Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
24761755	76	Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity.	University of Bath
24690494	92	Antagonists of the kappa opioid receptor.	The Scripps Research Institute
24900842	71	Novel delta opioid receptor agonists with oxazatricyclodecane structure.	Kitasato University
24602401	40	[Dmt(1)]DALDA analogues with enhancedµ opioid agonist potency and with a mixedµ/¿ opioid activity profile.	Nanjing Medical University
15743203	272	3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies.	University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
23438330	174	Orvinols with mixed kappa/mu opioid receptor agonist activity.	University of Bath
23360448	18	Development of¿ opioid receptor antagonists.	Research Triangle Institute
23200250	36	The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives.	Kitasato University
16290934	51	Highly potent and selective zwitterionic agonists of the delta-opioid receptor. Part 1.	Pfizer
23131341	50	Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).	Kitasato University
23103094	39	Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.	Kitasato University
22325949	28	Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at thed opioid receptor. Discovery of two highly potent and selectived opioid agonists.	Clinical Research Institute of Montreal
23134120	72	Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective¿ opioid receptor agonist.	University of Innsbruck
23102273	60	Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.	Vrije Universiteit Brussel
23043264	20	Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversibleµ opioid receptor antagonist effects.	University of Bristol
22695132	56	Identification of a duald OR antagonist/µ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).	Janssen Research and Development
22967810	102	Synthesis of quinolinomorphinan derivatives as highly selectived opioid receptor ligands.	Kitasato University
22742909	24	Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.	Kitasato University
22583618	8	Kappa agonist CovX-Bodies.	Pfizer
22460026	39	Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.	Kitasato University
22445285	26	Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.	Kitasato University
21641798	16	Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.	Kitasato University
20931963	112	Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.	Aska Pharmaceutical
20599386	46	Evaluation of N-substitution in 6,7-benzomorphan compounds.	University of Catania
20580236	60	Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.	University of Innsbruck and Center For Molecular Biosciences Innsbruck-Cmbi
20441176	76	Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives.	Wilhelms-Universit£T M£Nster
20218625	27	"Carba"-analogues of fentanyl are opioid receptor agonists.	Clinical Research Institute of Montreal
19962305	2	Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology.	Kitasato University
19362480	22	Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.	Kitasato University
19349178	4	Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction.	Kitasato University
19464172	74	Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208.	Adolor
19253983	37	14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity.	University of Bath
18755589	2	Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.	Kitasato University
19027293	149	Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.	Rensselaer Polytechnic Institute
18990576	11	Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.	Kitasato University
18829333	28	Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.	Toray Industries
18637671	21	Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.	Toray Industries
18468907	64	Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.	Torrey Pines Institute For Molecular Studies
18337104	7	Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.	Kitasato University
17420073	31	Synthesis of bridged piperazines with sigma receptor affinity.	Institut F£R Pharmazeutische Und Medizinische Chemie
17402725	9	Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors.	University of Missouri-Columbia
17004724	146	Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring.	University of Bristol
16913723	78	Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones.	University of Bristol
16777416	80	Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.	University of Kentucky
15857143	48	Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.	Sapienza University of Rome
14998329	142	Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].	Southern Research Institute
14761209	15	Importance of phenolic address groups in opioid kappa receptor selective antagonists.	Research Triangle Institute
12593647	49	2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists.	Harvard University
12930147	96	Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.	Universit£
12825951	54	Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.	Research Triangle Institute
12801235	5	Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents.	University of Vermont
12723940	145	2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.	Research Triangle Institute
12431065	72	Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans.	University of Innsbruck
12139463	24	Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.	Research Triangle Institute
11311071	53	Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.	National Institute of Diabetes and Digestive and Kidney Diseases
11543672	24	[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.	Clinical Research Institute of Montreal
11495592	12	Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional studies.	Pharmazeutisches Institut Der Universit£T Freiburg
11495579	24	Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.	Research Triangle Institute
10794701	48	Structural determinants of opioid activity in the orvinols and related structures: ethers of orvinol and isoorvinol.	University of Bristol
10753461	13	Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.	University of Minnesota
11000010	27	Selective protection and functionalization of morphine: synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives.	Rensselaer Polytechnic Institute
10956208	121	Nonpeptide analogues of dynorphin A(1-8): design, synthesis, and pharmacological evaluation of kappa-selective agonists.	University of Catania
10841791	8	Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations.	Universit£
10633042	30	Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence.	Harvard Medical School
10229636	30	delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.	National Institute of Diabetes
10639287	62	Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.	National Institute of Diabetes and Digestive and Kidney Diseases
10479286	53	Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.	Southern Research Institute
9857089	32	Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.	Research Triangle Institute
9857087	63	Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile.	Vrije Universiteit Brussel
9667975	86	Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.	Southern Research Institute
9057861	33	(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.	University of Washington
9288176	95	Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.	National Institute of Diabetes and Digestive and Kidney Diseases
8627605	10	Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide"address" recognition at kappa opioid receptors.	University of Minnesota
8648612	30	Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells.	University of Minnesota
8642567	64	Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.	National Institute of Diabetes and Digestive and Kidney Diseases
7739013	26	Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.	Research Triangle Institute
7739011	90	Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.	National Institute of Diabetes and Digestive and Kidney Diseases
7853350	33	Isothiocyanate-substituted benzyl ether opioid receptor ligands derived from 6 beta-naltrexol.	University of Washington
7853332	27	7'-Substituted amino acid conjugates of naltrindole. Hydrophilic groups as determinants of selective antagonism of delta 1 opioid receptor-mediated antinociception in mice.	University of Minnesota
7636870	18	Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-Hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime.	University of Innsbruck
8126697	30	Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety.	University of Minnesota
7996538	42	Synthesis and opioid receptor affinity of a series of aralkyl ethers of 6 alpha- and 6 beta-naltrexol.	University of Washington
8071934	30	Isothiocyanate-substituted kappa-selective opioid receptor ligands derived from N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl] phenylacetamide.	University of Washington
8021929	13	Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety.	University of Minnesota
8182708	18	Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor.	University of Minnesota
8394935	4	A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists.	University of Minnesota
8360887	9	Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity.	University of Minnesota
8390575	28	Non-peptide ligands for opioid receptors. Design of kappa-specific agonists.	Universit£
8380614	6	A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists.	University of Minnesota
1315870	39	Substitution on the Phe3 aromatic ring in cyclic delta opioid receptor-selective dermorphin/deltorphin tetrapeptide analogues: electronic and lipophilic requirements for receptor affinity.	University of Michigan
1361580	25	N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors.	Oregon State University
1335078	76	O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.	University of Washington
1333014	12	Incorporation of a novel conformationally restricted tyrosine analog into a cyclic, delta opioid receptor selective tetrapeptide (JOM-13) enhances delta receptor binding affinity and selectivity.	University of Michigan
1333013	29	Opioid agonist and antagonist activities of morphindoles related to naltrindole.	University of Minnesota
1323679	21	Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for kappa and mu opioid receptors.	Zambeletti Research Laboratories
1322988	60	Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo	National Institute of Diabetes and Digestive and Kidney Diseases
1320121	48	Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol.	University of Washington
1319495	21	Selective reversible and irreversible ligands for the kappa opioid receptor.	National Taiwan University
1319493	31	Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.	National Institute of Diabetes and Digestive and Kidney Diseases
1648136	12	An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.	University of Minnesota
1851846	23	Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.	University of Minnesota
1849995	12	Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine.	University of Minnesota
1659636	51	Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists.	Ici Pharmaceuticals Group
1846919	26	Highly selective kappa opioid analgesics. 4. Synthesis of some conformationally restricted naphthalene derivatives with high receptor affinity and selectivity.	Parke-Davis Research Unit
2167979	43	Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.	Universit£
2160538	84	Design of peptidomimetic delta opioid receptor antagonists using the message-address concept.	University of Minnesota
2172538	58	Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.	National Institute of Diabetes and Digestive and Kidney Diseases
2153208	3	Highly selective kappa-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives.	Parke-Davis Research Unit
2547074	16	Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.	National Institute of Digestive
2542556	65	Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides.	Ciba-Geigy
2832603	68	Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.	Parke-Davis Research Unit
2831363	19	Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines.	Eli Lilly
2845084	22	Effects of addition of a 2-methyl group to ethyl nipecotates (beta-meperidines) on receptor affinities and opiate agonist/antagonist activities.	Sri International
2887656	48	Synthesis and activity profiles of new dermorphin-(1-4) peptide analogues.	TBA
2879914	30	Peptides as receptor selectivity modulators of opiate pharmacophores.	TBA
2409281	9	10-Ketonaltrexone and 10-ketooxymorphone.	TBA
12565965	45	Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.	Southern Research Institute
11294396	57	Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole.	University of Bristol
11591513	87	Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan.	Harvard Medical School
11425545	22	3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.	Pharmacia
11055333	21	Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series.	University of Bristol
10673107	63	8-Aminocyclazocine analogues: synthesis and structure-activity relationships.	Institute
10340622	47	Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin.	Organon Laboratories
10206545	40	Ring constrained analogues of the orvinols: the furanomorphides.	University of Bristol
10617086	21	Delta opioid binding selectivity of 3-ether analogs of naltrindole.	National Institute of Diabetes
10612597	31	Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.	Research Triangle Institute
10571174	25	(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.	Research Triangle Institute
9871544	24	Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.	National Institute of Diabetes
9873603	23	Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models.	University of Michigan
	9	Synthesis and biological evaluation of 14-alkoxymorphinans.12.1 A phenethyl analogue of the -selective opioid receptor antagonist cyprodime	TBA
	51	EMD 61 753 as a favourable representative of structurally novel arylacetamido-type K opiate receptor agonists	TBA
	21	Neurotensin receptor binding and antinociceptive activity for lipophilic N-amido neurotensin(913) analogs	TBA
22197670	51	Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists.	Kitasato University
21967807	36	Identification of a potent and selectives¿? receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells.	University of Pavia
21889335	27	Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).	Kitasato University
21641219	12	Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons.	Kitasato University
21481987	27	Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: fine tuning of the dihedral angle of the ethylenediamine pharmacophore.	Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
21413804	21	Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.	Vrije Universiteit Brussel
21256034	58	Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies.	Kitasato University
20850307	27	Design and synthesis of KNT-127, ad-opioid receptor agonist effective by systemic administration.	Kitasato University
20685120	20	Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists.	Kitasato University
20483601	22	Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology.	Kitasato University
19818611	100	Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.	Schering-Plough Research Institute
20056539	14	Investigation of Beckett-Casy model 1: synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology.	Kitasato University
20045339	16	Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).	University of Pavia
19827750	39	Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).	Clinical Research Institute of Montreal
19576786	129	Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.	Institute For Molecular Studies
19620007	4	Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative.	Kitasato University
	21	Arylacetamide kappa-selective opioid ligands	TBA
	26	6N-Cinnamoyl-β-naltrexamine and its p-nitro derivative. High efficacy κ-opioid agonists with weak antagonist actions	TBA
	24	Morphinan cyclic imines and pyrrolidines containing a constrained phenyl group: High affinity opioid agonists	TBA
	9	Octahydro-1,2,3,4,4a,5,11,11a-pyrido[3,4-c][1,5]benzoxazepines: conformationally restricted fentanyl analogs	TBA
	22	Palladium-catalyzed synthesis of C3-substituted 3-deoxymorphines.	TBA
	6	New potent enkephalin analogs containing trifluoromethylamino acid residues	TBA
18800771	26	Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].	National University of Singapore
17497839	72	Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.	Kobe Gakuin University
17315860	40	Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.	Clinical Research Institute of Montreal
17166723	141	Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties.	Organon Laboratories
16913729	9	Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists.	National University of Singapore
15456245	44	Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.	Johnson & Johnson Pharmaceutical Research & Development
15324897	3	A novel cyclic enkephalin analogue with potent opioid antagonist activity.	Clinical Research Institute of Montreal
14695830	111	10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors.	Harvard Medical School
12749896	47	Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues.	Rensselaer Polytechnic Institute
12672226	9	A novel N-terminal cyclic dynorphin A analogue cyclo(N,5)[Trp(3),Trp(4),Glu(5)] dynorphin A-(1-11)NH(2) that lacks the basic N-terminus.	University of Maryland
12593663	146	Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.	Rensselaer Polytechnic Institute
12383009	2	Kappa-opioid receptor model in a phospholipid bilayer: molecular dynamics simulation.	University of Catania
12190304	10	Solid phase synthesis and evaluation of Tyr-Tic-Phe-Phe(p-NHCOCH(2)Br) ([Phe(p-bromoacetamide)(4)]TIPP), a potent affinity label for delta opioid receptors.	University of Maryland
11755345	45	Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives.	Niddk
11266156	42	8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines.	Rensselaer Polytechnic Institute
32435370	45	Novel	University of Catania
10866400	18	4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.	Research Triangle Institute
10841790	24	Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes.	Istituto Di Chimica Farmaceutica E Tossicologica
31857840	92	Discovery of Axelopran (TD-1211): A Peripherally Restricted ?-Opioid Receptor Antagonist.	Theravance Biopharma Us
31550662	109	Progress in the development of more effective and safer analgesics for pain management.	University of Catania
10479285	17	The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.	Clinical Research Institute of Montreal
10340623	31	Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis.	Organon Laboratories
30939014	143	Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety.	Universit£T M£Nster
30924650	73	Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic ?-Opioid Receptor (MOR) Agonist/?-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability.	University of Michigan
30543421	74	Development of Novel Quinoxaline-Based ?-Opioid Receptor Agonists for the Treatment of Neuroinflammation.	Universit£T M£Nster
9873693	24	N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.	Research Triangle Institute
9873439	18	C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study.	National Taiwan University
31220675	88	Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.	Biological Research Centre of The Hungarian Academy of Sciences
9767649	24	N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.	Research Triangle Institute
9599247	57	Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.	Research Triangle Institute
30822708	24	(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist.	University of Catania
9276018	47	Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.	Oregon State University
9111295	48	Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the"address" sequence.	Oregon State University
8893842	6	Aspartic acid conjugates of 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1(3-aminophenyl)-2-(1-pyrrolidi nyl) ethyl]acetamide: kappa opioid receptor agonists with limited access to the central nervous system.	University of Minnesota
8691442	52	Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.	University of Arizona
8676350	39	Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.	University of Arizona
8642554	42	Asymmetric syntheses, opioid receptor affinities, and antinociceptive effects of 8-amino-5,9-methanobenzocyclooctenes, a new class of structural analogues of the morphine alkaloids.	Institute
8632410	33	Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.	Universitá
8558529	195	Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.	Hoechst-Roussel Pharmaceuticals
8410999	81	3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.	Eli Lilly
8410998	129	Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors.	Eli Lilly
8201586	3	2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice.	University of Minnesota
24262888	105	The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, ? opioid receptor agonists.	Kitasato University
8097539	10	Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid.	Oregon State University
8096246	70	Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.	University of Arizona
8057274	18	Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.	Eli Lilly
23932788	60	N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.	Clinical Research Institute of Montreal
7966152	57	Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11.	University of Arizona
23822516	142	Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations.	Universit£
7932540	38	A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.	National Institute of Diabetes and Digestive and Kidney Diseases
7932535	40	Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols.	National Taiwan University
23517479	13	Orally active opioid compounds from a non-poppy source.	Temple University
23623711	82	Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies.	Kitasato University
7861405	9	Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2.	University of Arizona
7799399	8	kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists.	University of Minnesota
7731019	16	Electrophilic N-benzylnaltrindoles as delta opioid receptor-selective antagonists.	University of Minnesota
7707326	39	Opioid receptor binding requirements for the delta-selective peptide deltorphin. I: Phe3 replacement with ring-substituted and heterocyclic amino acids.	Eastern Michigan University
7658433	27	Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1.	University of Arizona
7608905	24	Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 1. Conformational constraint in the"message" sequence.	Oregon State University
7490727	72	(E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype.	National Institute of Diabetes and Digestive and Kidney Diseases
18249547	69	Structure-activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties.	Organon Laboratories
11960505	18	Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.	Chiba University
29107424	27	Selective kappa opioid antagonists for treatment of addiction, are we there yet?	University of Science and Technology
29477074	79	Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review.	University of Catania
3020244	45	Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors.	TBA
2876099	51	Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties.	TBA
30350997	111	Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic ? Receptor Ligands with Exocyclic Amino Moiety.	Universit£T M£Nster
28734666	23	Development of novel LP1-based analogues with enhanced delta opioid receptor profile.	University of Catania
1972964	40	Design and synthesis of highly potent and selective cyclic dynorphin A analogues.	University of Arizona
1895300	15	Modification of the enkephalin"message" with an artificial polycationic C-terminus.	Case Western Reserve University
1847432	13	New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics.	Anaquest
1846921	56	(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics.	Zambeletti Research Laboratories
1846918	12	2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists.	Ici Pharmaceuticals Group
1652025	45	(1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics.	Zambeletti Research Laboratories
28522254	42	Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities.	Kitasato University
1652019	12	Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers.	University of Washington
28499731	100	Discovery of N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenol and -phenyl carboxamide series of?-opioid receptor antagonists.	Theravance Biopharma Us
1360025	27	Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity.	Oregon State University
1315868	44	Phenylmorphans and analogues: opioid receptor subtype selectivity and effect of conformation on activity.	Harvard Medical School
26496515	11	Iminothiazoline-Sulfonamide Hybrids as Jack Bean Urease Inhibitors; Synthesis, Kinetic Mechanism and Computational Molecular Modeling.	Quaid-I-Azam University
26520885	21	Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents.	Hazara University
25996453	4	Synthesis of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives and their biological evaluation against protein tyrosine phosphatase 1B.	Jiangnan University