345 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28284805	10	Novel 2-phenyl-4,5,6,7-tetrahydro[b]benzothiophene analogues as selective COX-2 inhibitors: Design, synthesis, anti-inflammatory evaluation, and molecular docking studies.	Institute Of Chemical Technology
27837994	30	Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity.	Al-Azhar University
28089698	10	Novel 2,4-dichlorophenoxy acetic acid substituted thiazolidin-4-ones as anti-inflammatory agents: Design, synthesis and biological screening.	Jamia Hamdard (Hamdard University)
27889630	6	1,2,3-Triazolyl ester of Ketorolac: A"Click Chemistry"-based highly potent PAK1-blocking cancer-killer.	Kagoshima University
27894044	37	An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold.	University Of Kwazulu-Natal
28038322	38	Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.	Beni-Suef University
1995900	4	Romazarit: a potential disease-modifying antirheumatic drug.	Roche Products
2491889	1	Antiinflammatory 2,6-di-tert-butyl-4-(2-arylethenyl)phenols.	Boehringer Ingelheim Pharmaceuticals
3104589	2	Benzimidazole derivatives with atypical antiinflammatory activity.	TBA
28057407	76	Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.	Georgia Institute Of Technology
27916468	36	Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile.	Beni-Suef University
27842798	66	Synthesis, COX-1/2 inhibition activities and molecular docking study of isothiazolopyridine derivatives.	Wroclaw Medical University
27720548	16	Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents.	Kyung Hee University
27191614	4	The therapeutic voyage of pyrazole and its analogs: A review.	Jamia Hamdard
27349331	42	Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis.	Nanjing University
27019010	48	Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.	Guru Nanak Dev University
26898334	16	Design and synthesis of [(125)I]Pyricoxib: A novel (125)I-labeled cyclooxygenase-2 (COX-2) inhibitors.	University Of Alberta
26774927	120	Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.	Fondazione Istituto Italiano Di Tecnologia
26899595	32	A potent and selective inhibitor targeting human and murine 12/15-LOX.	University Of California
26850006	10	Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog.	University Of Alberta
26691756	38	Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.	Beni-Suef University
26372652	21	Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.	Rwth Aachen University
26316467	2	Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.	Hunan University Of Chinese Medicine
26088337	43	Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol.	University Of Innsbruck
26081289	14	Novel (pyrazolyl)benzenesulfonamides with a nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors.	Technische Universitat Dresden
26048794	22	Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2.	Bangalore University
25956953	51	Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.	Guru Nanak Dev University
25768707	17	General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.	Universit£
25980909	16	Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities.	Chinese Academy Of Sciences
25866240	56	Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors.	The First Affiliated Hospital Of Nanjing Medical University
25599836	14	Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.	Boehringer Ingelheim (Canada)
25868745	16	Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.	Hacettepe University
25819096	16	Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium.	Hunan University Of Chinese Medicine
25596758	5	Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.	Sapienza University Of Rome
25575659	124	SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.	Goethe-University Frankfurt
25016374	31	Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.	Griffith University
24938495	75	Pharmacological evaluation and docking studies ofa,ß-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines.	Universiti Kebangsaan Malaysia
24934992	50	Novel pyrazoline derivatives as bi-inhibitor of COX-2 and B-Raf in treating cervical carcinoma.	Second Affiliated Hospital Of Southeast University
24881566	140	Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).	Glaxosmithkline
24631898	17	Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.	Guru Nanak Dev University
25467164	20	Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.	Roseman University Of Health Sciences
25453800	3	Synthesis and PGE2 production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells.	TBA
25408841	108	Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.	Vanderbilt University School Of Medicine
25313331	34	Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties.	Institutes Of Biomedicine And Health
25221653	24	Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.	Minia University
24983538	16	Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.	Minia University
24920381	77	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.	University Jena
24900871	8	2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation.	National Institute Of Pharmaceutical Education And Research (Niper)
24844534	46	Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.	University Of Tuebingen
24836072	38	Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression.	Jamia Hamdard (Hamdard University)
24780593	46	Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.	Shoolini University
24745964	20	Design, synthesis, docking and anti-inflammatory evaluation of novel series of benzofuran based prodrugs.	Banaras Hindu University
24661847	8	Synthesis of thio-heterocyclic analogues from Baylis-Hillman bromides as potent cyclooxygenase-2 inhibitors.	Csir-Indian Institute Of Chemical Technology
24656662	33	Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.	Kyung Hee University
24650702	16	Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.	Keio University
24631895	14	1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.	Minia University
23473947	28	Synthesis, cyclooxygenase inhibitory effects, and molecular modeling study of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and -2-alkylsulfonyl-1H-imidazole derivatives.	Tehran University Of Medical Sciences
23534442	32	Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.	Universit£
23454516	92	Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.	University Of Auckland
23353741	117	Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents.	Hefei University Of Technology
23266122	47	Novel benzoxazole inhibitors of mPGES-1.	Pfizer
23237838	1	Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.	The University Of Arizona
23200247	30	Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.	University Of Alberta
15808476	15	QSAR analyses of conformationally restricted 1,5-diaryl pyrazoles as selective COX-2 inhibitors: application of connection table representation of ligands.	Devi Ahilya Vishwavidyalaya
15603946	67	QSAR studies on structurally similar 2-(4-methanesulfonylphenyl)pyran-4-ones as selective COX-2 inhibitors: a Hansch approach.	Devi Ahilya Vishwavidyalaya
11563921	305	Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.	Universit£
14552773	59	Exploring selectivity requirements for COX-2 versus COX-1 binding of 3,4-diaryloxazolones using E-state index.	Jadavpur University
23146282	3	Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones.	Devi Ahilya Vishwavidyalaya
23059546	2	Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents.	Jamia Hamdard (Hamdard University)
21413808	170	Synopsis of some recent tactical application of bioisosteres in drug design.	Bristol-Myers Squibb Pharmaceutical Research And Development
23043222	125	Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.	Istituto Italiano Di Tecnologia
22652053	6	Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins.	Rwth Aachen University
23062711	42	Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors.	Nanjing University
23010270	25	Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.	University Of Hyderabad Campus
24900267	9	Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable ¿-Secretase Modulator.	TBA
23047224	24	Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.	Hacettepe University
22819942	2	Synthesis of benzo-annulated tryptanthrins and their biological properties.	Yeungnam University
22404396	16	Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity.	Keio University
22263894	23	Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.	Vanderbilt Institute Of Chemical Biology
22749420	13	Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.	University Of Hamburg
22263837	262	Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17ß-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.	University Of Pennsylvania
22560838	7	Radiosynthesis of a¹8F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo.	Helmholtz-Zentrum Dresden-Rossendorf
22236250	16	Exploring activity cliffs in medicinal chemistry.	Rheinische Friedrich-Wilhelms-Universit£T
22091869	6	Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.	Faculdade De Ci�Ncias E Tecnologia-Unl
22516282	23	Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.	The University Of Arizona
22507964	17	Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.	Perelman School Of Medicine University Of Pennsylvania
22469703	32	Isoquinoline derivatives as potent CRTH2 receptor antagonists: synthesis and SAR.	Taisho Pharmaceutical
22475926	39	Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.	University Of Hacettepe
22386242	13	N-Caffeoyl serotonin as selective COX-2 inhibitor.	Kinki University
21280601	18	Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.	University Of Alberta
20576329	14	3-Formylchromones: potential antiinflammatory agents.	University Of Karachi
20451397	55	Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines.	Universit£
19791801	86	Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors.	University Of Liege
19884005	17	Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.	University Of Alberta
19500994	18	Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.	University Of Alberta
19053751	89	Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.	Eberhard Karls University Tuebingen
17976864	11	Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles.	Johannes Gutenberg University
11858749	32	Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.	University Of Illinois At Chicago
9784154	12	Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis.	Uppsala University
16038536	88	Expanding the ChemGPS chemical space with natural products.	Uppsala University
18363350	60	Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.	Okayama University Graduate School Of Medicine
17434872	38	Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.	Vanderbilt Institute For Chemical Biology
18158247	122	Novel 2-(4-methylsulfonylphenyl)pyrimidine derivatives as highly potent and specific COX-2 inhibitors.	Faes Farma
18063374	68	Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides.	Taipei Medical University
17994684	48	Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.	Nitromed
17517512	33	Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system.	Universitat De Barcelona
17346963	12	Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).	Institute For Natural Product Research And Infection Biology
16220969	219	Designed multiple ligands. An emerging drug discovery paradigm.	Organon Laboratories
15780608	12	Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.	National Institute Of Pharmaceutical Education And Research (Niper)
11906292	32	4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1).	Central Pharmaceutical Research Institute
11101350	72	1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite.	Institut De Recherche Servier
10649977	72	Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors.	RhôNe-Poulenc Rorer
10197970	88	2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
7562922	48	Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.	Dupont Pharmaceuticals
1635053	47	5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.	Wyeth-Ayerst Research
3918169	24	Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors.	TBA
10406640	31	The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.	Merck Frosst Centre For Therapeutic Research
9871729	7	Synthesis and anti-inflammatory activity of chalcone derivatives.	Universidad De Valencia
22386983	25	Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2).	University Of Alberta
22361134	26	N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.	University Of Alberta
22341941	34	Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors.	University Of Alberta
22148253	12	Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.	University Of Alberta
22373734	42	Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug.	Pfizer
21602044	6	Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo.	Shanghai Haini Pharmaceutical
24900317	11	Indomethacin Analogues that Enhance Doxorubicin Cytotoxicity in Multidrug Resistant Cells without Cox Inhibitory Activity.	TBA
22217871	6	Enzymatic transformation of caffeic acid with enhanced cyclooxygenase-2 inhibitory activity.	Kyungpook National University
22189137	2	Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation.	University Of Genoa
21992176	52	Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.	Sapienza University Of Rome
22119153	64	Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.	Alexander Technological Education Institute Of Thessaloniki
22059882	206	5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.	Amira Pharmaceuticals
22000948	50	Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors.	Nanjing University
21958738	6	Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.	Universiti Putra Malaysia
21958737	24	Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.	National Taiwan University
21868137	69	Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.	Gazi University
21873070	29	SAR studies of acidic dual¿-secretase/PPAR¿ modulators.	Goethe-University Frankfurt
21775152	1	Effects ofß-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.	Shanghai University Of Traditional Chinese Medicine
21752640	6	Bioactive sulfoximines: syntheses and properties of Vioxx analogs.	Rwth Aachen University
21739938	72	Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.	National Human Genome Research Institute
21570308	55	Synthesis and biological evaluation of loxoprofen derivatives.	Kumamoto University
21641217	10	A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.	University Of Alberta
19476340	2	Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.	Ghent University-Ugent
21524587	6	Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors.	Universit£T Leipzig
21542630	135	Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase.	Peking University
21319773	8	Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro.	University Of Veterinary And Pharmaceutical Sciences Brno
21434686	48	Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.	University Of California
21345672	28	Synthesis, biological evaluation and molecular docking studies of stellatin derivatives as cyclooxygenase (COX-1, COX-2) inhibitors and anti-inflammatory agents.	National Institute Of Pharmaceutical Education And Research (Niper)
21316237	12	Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors.	University Of Alberta
21215625	40	Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors.	Pfizer
21211969	42	Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.	Amira Pharmaceuticals
20970223	10	Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents.	Alexandria University
20709553	72	The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life.	Pfizer
20974503	13	Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors.	Sapienza University Of Rome
21055613	31	The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate.	Pfizer
20728356	68	The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: the three microdose candidates.	Pfizer
20954731	18	Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities.	Kumamoto University
20727750	9	Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.	University Of Alberta
20813948	63	Spiroindolones, a potent compound class for the treatment of malaria.	Swiss Tropical And Public Health Institute
20655211	18	Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease.	University Of Alberta
20576432	16	Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.	University Of Alberta
20566292	6	5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.	Amira Pharmaceuticals
20540535	48	Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity.	Peking University Health Science Center
20527891	7	Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.	Purdue University
20503989	29	Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.	Zafes/Liff/Goethe University Frankfurt
20202839	13	Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.	University Of Alberta
20144869	90	Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template.	Pfizer
20056549	12	Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.	National Taiwan University
20045320	14	Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.	University Of Alberta
19957931	66	Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.	Sapienza University Of Rome
20097072	14	Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.	University Of Alberta
20004572	11	Synthesis and PGE(2) production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives.	Kyung Hee University
19540763	4	Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.	University Of Arizona
19523822	33	Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.	Glaxosmithkline
19520573	108	Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.	Glaxosmithkline
19592244	61	7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.	Novartis Institutes Of Biomedical Research
19427206	5	The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives.	Vanderbilt University School Of Medicine
	22	3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2	TBA
	49	A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles	TBA
	46	Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors	TBA
	50	Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitors	TBA
	30	Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors	TBA
	25	Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors	TBA
	2	Syntheses and biological evaluation of two new naproxen analogs	TBA
	48	Synthesis and biological evaluation of 2,3-diarylthiophenes as selective cox-2 inhibitors. part II: Replacing the heterocycle	TBA
	20	Selective cyclooxygenase inhibitors: Novel 4-spiro 1,2-diarylcyclopentenes are potent and orally active cox-2 inhibitors	TBA
	18	3,4-diarylthiophenes are selective COX-2 inhibitors	TBA
	16	Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors	TBA
	51	Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors	TBA
	21	1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitor	TBA
19423356	1	Synthesis and biological evaluation of 3,4,6-triaryl-2-pyranones as a potential new class of anti-breast cancer agents.	Central Drug Research Institute
19419861	18	Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.	University Of Alberta
19296694	12	Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.	University Of Alberta
19286379	8	Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.	Chinese Academy Of Medical Sciences
19233646	7	Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.	University Of Medicine And Pharmacy At Ho Chi Minh City
19200742	3	Inhibition of iNOS and COX-2 in human whole blood ex vivo and monocyte-macrophage J774 cells by a new group of aminothiopyrimidone derivatives.	University Of Catania
19188072	1	Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones.	UniversitäT Bayreuth
19157881	28	Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives.	University Of Alberta
19136259	14	Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.	University Of Alberta
19135376	4	Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.	Universidade Federal Do Rio De Janeiro
19097798	50	Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.	Johannes Gutenberg University
19059783	3	Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes.	Federal University Of Rio De Janeiro
19056264	6	Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors.	Institute
19053765	15	New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide.	Martin-Luther-Universitaet
18976930	10	Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.	National Institute Of Advanced Industrial Science And Technology (Aist)
18752957	44	Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.	Sapienza University Of Rome
18667313	22	New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines.	Université
18650097	4	Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor.	Institute Of Radiopharmacy
18598017	28	Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.	Universita Di Siena
18487053	55	Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB.	Purdue University
18262309	24	2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols.	Guru Nanak Dev University
17714833	31	Exploration of physicochemical properties and molecular modelling studies of 2-sulfonyl-phenyl-3-phenyl-indole analogs as cyclooxygenase-2 inhibitors.	Institute Of Technology And Science
17532544	10	Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.	University Of Alexandria
16792405	11	Nitrogen-containing phorbol esters from Croton ciliatoglandulifer and their effects on cyclooxygenases-1 and -2.	Centro De Investigaciones QuíMicas De La Universidad AutóNoma Del Estado De Morelos
16562850	1	Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.	Mahidol University
16252917	8	Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum.	Chinese Academy Of Sciences
12444669	10	Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.	Uppsala University
11170689	6	Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures.	University Of Illinois At Chicago
10075763	6	Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries.	Department Of Horticulture And National Food Safety And Toxicology Center
18072726	4	New celecoxib derivatives as anti-inflammatory agents.	Gedeon Richter
17915854	38	Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.	Sapienza University Of Rome
17822894	10	Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.	Shaheed Beheshti University Of Medical Sciences
17604631	22	'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.	University Of Vienna
17480099	14	Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities.	Chiang Mai University
17378609	29	Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.	Tahitian Noni International
17341061	21	Structural and functional basis of cyclooxygenase inhibition.	Institute For Chemical Biology And Center In Molecular Toxicology
17335184	26	NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties.	Università
16814546	41	Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.	National Research Institute Of Chinese Medicine
16806914	6	Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.	Tehran University Of Medical Sciences
16753296	25	Discovery of potent CRTh2 (DP2) receptor antagonists.	Astrazeneca R&D Charnwood
16647258	11	Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors.	RhôNe-Poulenc Rorer
16616494	4	Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx and Arcoxia.	RhôNe-Poulenc Rorer
16275075	63	5-heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure-activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog.	Veterinary Medicine Research And Development Pfizer
16250658	8	Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors.	Johann Wolfgang Goethe-UniversitäT
16190777	6	Synthesis and pharmacological evaluation of 1H-imidazoles as ligands for the estrogen receptor and cytotoxic inhibitors of the cyclooxygenase.	Free University Of Berlin
16153836	7	Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography.	University Of California Los Angeles
16134939	67	Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.	Chiesi Farmaceutici
15993594	4	In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I.	Università
15936193	4	Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia.	Merck Research Laboratories
15916445	8	3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone as a potent and orally active cyclooxygenase-2 selective inhibitor: synthesis and biological evaluation.	Nitromed
15887968	13	Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1.	Vanderbilt University
15837305	4	Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.	Merck Research Laboratories
15808467	1	A general carbometalation, three component coupling strategy for the synthesis of alpha,beta-unsaturated gamma-sultines including thio-rofecoxib, a selective COX-2 inhibitor.	Methylgene
15615524	58	Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.	Université
15566290	60	New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.	Université
15546727	6	3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.	Nitromed
15454242	48	Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.	Glaxosmithkline
15369392	22	Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal.	Università
15324899	83	Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors.	Roche Palo Alto
15324885	56	Exploring QSAR with E-state index: selectivity requirements for COX-2 versus COX-1 binding of terphenyl methyl sulfones and sulfonamides.	Jadavpur University
15239665	83	Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors.	RhôNe-Poulenc Rorer
15084117	10	Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazoles.	Nitromed
15026050	31	Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.	Discovery Research-Dr. Reddy'S Laboratories
14980665	33	Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.	Merck Frosst Centre For Therapeutic Research
14698190	44	Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.	Discovery Research-Dr. Reddy'S Laboratories
14698178	8	1,2-Diaryl-1-ethanone and pyrazolo [4,3-c] quinoline-4-one as novel selective cyclooxygenase-2 inhibitors.	Dr. Reddy'S Laboratories
14640557	19	Synthesis and structure-activity relationship of novel, highly potent metharyl and methcycloalkyl cyclooxygenase-2 (COX-2) selective inhibitors.	Nitromed
12954051	10	Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.	Dr. Reddy'S Laboratories
12877584	182	Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.	Domp&Egrove
12729631	16	Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors.	Dr. Reddy'S Laboratories
12643942	82	3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.	Merck Frosst Centre For Therapeutic Research
12639552	25	Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors.	Vittal Mallya Scientific Research Foundation
12639538	90	Pyridazinones as selective cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
12408728	6	Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.	Université
12392741	7	Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.	Merck Frosst Centre For Therapeutic Research
12217369	16	Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors.	University Of Alberta
11965379	94	Enantiospecific, selective cyclooxygenase-2 inhibitors.	Vanderbilt University School Of Medicine
11906281	22	Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.	Laboratorios Menarini
11859001	30	Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.	Laboratoires Innothera
11844666	31	Structure-based design of cyclooxygenase-2 selectivity into ketoprofen.	Laboratorios Menarini
11844663	54	Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.	Vanderbilt University School Of Medicine
11814774	50	Estimation of binding affinities for celecoxib analogues with COX-2 via Monte Carlo-extended linear response.	Yale University
11738574	36	4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.	Central Pharmaceutical Research Institute
11520213	12	Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere.	University Of Alberta
11520200	17	Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity.	University Of Alberta
11462976	20	Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.	J. Uriach & CíA.
11412982	2	Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata.	University Of Illinois At Chicago
11392547	15	Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.	Abbott Laboratories
11327589	11	In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).	Merck Frosst Centre For Therapeutic Research
11262075	3	Perspectives in animal health: old targets and new opportunities.	Merck Research Laboratories
11128651	18	Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).	Merck Frosst Centre For Therapeutic Research
10956225	106	Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.	Pfizer
10956194	152	Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.	Vanderbilt University School Of Medicine
10937738	38	Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors.	University Of Barcelona
10841807	6	Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity of ketoprofen analogues.	Laboratorios Menarini
10794682	4	N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.	Pfizer
10741562	60	1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2.	The R. W. Johnson Pharmaceutical Research Institute
10715145	9	4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.	Searle Research And Development
10576685	63	Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
10576684	67	A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
10465547	24	SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.	Merck Frosst Centre For Therapeutic Research
10397507	42	2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
10328307	24	Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors.	G.D. Searle-Monsanto
10328306	58	Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors.	G.D. Searle-Monsanto
10230611	48	Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.	Dupont Pharmaceuticals
10197960	171	Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.	Warner-Lambert
10197959	92	Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.	Warner-Lambert
10091674	36	Structure-based design of COX-2 selectivity into flurbiprofen.	Merck Frosst Canada
10021918	59	Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.	Merck Frosst Centre For Therapeutic Research
9873621	48	2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.	Merck Frosst Centre For Therapeutic Research
9871731	14	Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2.	Boehringer Ingelheim Pharmaceuticals
9871612	8	Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.	Abbott Laboratories
9822550	98	Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.	Center In Molecular Toxicology And The Vanderbilt Cancer Center
9719605	62	New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.	Procter & Gamble Pharmaceuticals
9544212	37	New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.	Procter & Gamble Pharmaceuticals
9544211	39	New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent.	Procter & Gamble Pharmaceuticals
9171873	192	1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.	Searle Research And Development
9171872	85	1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.	Searle Research And Development
9135032	217	Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).	Searle Research And Development
9083488	29	Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.	Boehringer Ingelheim Pharmaceuticals
9057869	25	Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.	Abbott Laboratories
8627608	100	Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.	Searle Research And Development
8568815	70	Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships.	Searle Research And Development
8523403	50	Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives.	Merck Frosst Centre For Therapeutic Research
8254620	62	3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.	Tokushima Bunri University
8246226	89	Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.	Ciba-Geigy
7966148	40	Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.	Searle Research & Development
7473585	70	1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.	Searle Research And Development
3669017	8	Phenylephrine derivatives as leukotriene D4 antagonists.	Wyeth Laboratories
3346867	6	Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.	Wellcome Research Laboratories
2113949	126	Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors.	Boehringer Ingelheim Pharmaceuticals
26642829	34	Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects.	Atat£Rk University
19374401	103	Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.	Kalypsys
18294849	11	Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity.	Astrazeneca