The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27639363 |
141 |
Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics. |
Huazhong University of Science and Technology |
| 26820556 |
156 |
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus. |
Dipartimento Di Farmacia Universit£ |
| 26483200 |
100 |
Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics. |
Huazhong University of Science and Technology |
| 26164842 |
30 |
Bifunctional compounds targeting both D2 and non-a7 nACh receptors: design, synthesis and pharmacological characterization. |
Universit£ |
| 25936259 |
55 |
Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent. |
Jagiellonian University Medical College |
| 25461306 |
16 |
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells. |
Universit£ |
| 25435254 |
82 |
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT1A receptor functional profile. |
Jagiellonian University Medical College |
| 24559051 |
141 |
Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders. |
Intra-Cellular Therapies |
| 8201608 |
28 |
Molecular similarity, quantitative chirality, and QSAR for chiral drugs. |
University of Oxford |
| 1676759 |
12 |
Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone. |
University of Santiago De Compostela |
| 23353740 |
21 |
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
Universidade Federal De Goi£S |
| 1317923 |
48 |
Spiropiperidines as high-affinity, selective sigma ligands. |
Merck Sharp and Dohme Research Laboratories |
| 1317922 |
48 |
Benz[f]isoquinoline analogues as high-affinity sigma ligands. |
Merck Sharp and Dohme Research Laboratories |
| 3373482 |
50 |
Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor. |
Merrell Dow Research Institute |
| 15808487 |
137 |
The role of QSAR in dopamine interactions. |
Pomona College |
| 7907148 |
32 |
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. |
University of Li£Ge |
| 2824774 |
3 |
Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and sigma receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines. |
University of Lausanne |
| 12482418 |
18 |
New arylpiperazine derivatives with high affinity for alpha1A, D2 and 5-HT2A receptors. |
University of Santiago |
| 11755365 |
113 |
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2. |
Janssen-Cilag |
| 11755364 |
104 |
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1. |
Janssen-Cilag |
| 11454468 |
35 |
Discovery and SAR of org 24598-a selective glycine uptake inhibitor. |
Organon Research and Development Group |
| 9934473 |
16 |
Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors. |
Universidad De Santiago De Compostela |
| 9871765 |
14 |
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. |
University of Bologna |
| 23275802 |
32 |
Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. |
TBA |
| 22642365 |
62 |
Structure-activity relationship study of N6-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterizatio |
Wayne State University |
| 22537450 |
54 |
Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. |
Gedeon Richter |
| 21816515 |
93 |
Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1. |
Medical University of Warsaw |
| 21666830 |
82 |
Synthesis and Biological Evaluation of N-Fluoroalkyl and 2-Fluoroalkoxy Substituted Aporphines: Potential PET Ligands for Dopamine D(2) Receptors. |
Harvard Medical School |
| 19831400 |
47 |
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. |
European Research Centre For Drug Discovery and Development (Natsyndrugs) |
| 19053780 |
76 |
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. |
Universita Degli Studi Di Bari |
| 18278854 |
20 |
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. |
The University of Mississippi |
| 17228858 |
236 |
Advances in development of dopaminergic aporphinoids. |
Chinese Academy of Sciences |
| 17267226 |
46 |
Novel piperazines: potent melanocortin-4 receptor antagonists with anxiolytic-like activity. |
Taisho Pharmaceutical |
| 17154515 |
40 |
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
Purdue University |
| 16250647 |
71 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
Universit£ |
| 16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
| 15916415 |
150 |
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents. |
National Institute On Drug Abuse-Intramural Research Program |
| 15634021 |
113 |
Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. |
Universit£ |
| 15914001 |
16 |
New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects. |
Daiichi Suntory Biomedical Research |
| 15239663 |
60 |
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. |
Abbott Laboratories |
| 12593651 |
107 |
Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity. |
Dainippon Pharmaceutical |
| 12519065 |
243 |
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists. |
H. Lundbeck |
| 12930145 |
77 |
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors. |
Universit£ |
| 12361392 |
62 |
Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors. |
Universit£ |
| 11784139 |
82 |
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies. |
Universit£ |
| 11708905 |
20 |
N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy. |
Eli Lilly |
| 10715162 |
59 |
Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype. |
Cocensys |
| 11000009 |
23 |
Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists. |
University of Maastricht |
| 10978184 |
3 |
Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity. |
Suntory Biomedical Research |
| 10956209 |
79 |
CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors. |
University of Texas |
| 10956195 |
38 |
Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
University Centre For Pharmacy |
| 10821720 |
8 |
7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new heterocyclic system and a new lead compound for dopamine receptor antagonists. |
University of Bonn |
| 10090790 |
131 |
Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine sigma ligands as potential antipsychotic drugs. |
Taisho Pharmaceutical |
| 10602693 |
64 |
Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. |
Wyeth-Ayerst Research |
| 10508444 |
58 |
Synthesis and SAR of 1-alkyl-2-phenylethylamine derivatives designed from N,N-dipropyl-4-methoxy-3-(2-phenylethoxy)phenylethylamine to discover sigma(1) ligands. |
Taisho Pharmaceutical |
| 9804688 |
51 |
Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes. |
University of Minnesota |
| 9767652 |
12 |
N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies. |
University of Crete |
| 9748351 |
16 |
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure. |
Universita' Di Siena |
| 9622541 |
97 |
Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. |
R. W. Johnson Pharmaceutical Research Institute |
| 9572883 |
32 |
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties. |
University of Catania |
| 9111299 |
25 |
N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor. |
Yamanouchi Pharmaceutical |
| 9435894 |
206 |
New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans. |
Wyeth-Ayerst Research Laboratories |
| 9171869 |
114 |
Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
Abbott Laboratories |
| 8676355 |
90 |
Structure-activity relationships of a series of substituted benzamides: potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents. |
Glaxo Wellcome |
| 8632409 |
15 |
Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors. |
Va Medical Center |
| 8960552 |
58 |
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4. |
Universit£ |
| 8863803 |
22 |
Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives. |
Universit£ |
| 8863801 |
40 |
Synthesis, resolution, and preliminary evaluation of trans-2-amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes and related derivatives as dopamine receptors ligands. |
Universit£ |
| 8831770 |
136 |
Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate. |
Hoechst Marion Roussel |
| 8759642 |
53 |
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3. |
Universit£ |
| 7707315 |
58 |
3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873). |
Hoechst-Roussel Pharmaceuticals |
| 8523409 |
37 |
1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding. |
Neurogen |
| 7473556 |
30 |
(+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists. |
National Institutes of Health |
| 7473548 |
74 |
N-aryl-N'-benzylpiperazines as potential antipsychotic agents. |
R. W. Johnson Pharmaceutical Research Institute |
| 7473547 |
103 |
Piperazinylalkyl heterocycles as potential antipsychotic agents. |
R. W. Johnson Pharmaceutical Research Institute |
| 7783153 |
189 |
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology. |
Upjohn Laboratories |
| 7783131 |
78 |
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. |
H. Lundbeck |
| 8176710 |
24 |
Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. |
Cifa Universidad De Navarra |
| 7990124 |
11 |
Studies of the active conformation of a novel series of benzamide dopamine D2 agonists. |
Warner-Lambert |
| 8064801 |
232 |
Substituted (S)-phenylpiperidines and rigid congeners as preferential dopamine autoreceptor antagonists: synthesis and structure-activity relationships. |
University of G£Teborg |
| 8027978 |
50 |
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds. |
Albany Molecular Research |
| 8097538 |
69 |
Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives. |
Upjohn Laboratories |
| 8246241 |
34 |
18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. |
University of Pennsylvania |
| 7901417 |
5 |
Conformationally restricted analogues of remoxipride as potential antipsychotic agents. |
Burroughs Wellcome |
| 8230131 |
25 |
Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
Medicinaregatan |
| 8410990 |
141 |
Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans. |
H. Lundbeck |
| 8102651 |
53 |
Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity. |
University of North Carolina |
| 8098771 |
19 |
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand. |
University of Pennsylvania |
| 8496900 |
136 |
Comparison of 5-HT1A and dopamine D2 pharmacophores. X-ray structures and affinities of conformationally constrained ligands. |
Upjohn Laboratories |
| 1573641 |
60 |
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype. |
Searle Research and Development |
| 1348089 |
71 |
Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds. |
Upjohn Laboratories |
| 1346653 |
168 |
Pyrrole mannich bases as potential antipsychotic agents. |
R. W. Johnson Pharmaceutical Research Institute |
| 1361578 |
99 |
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. |
Bristol-Myers Squibb |
| 1360027 |
16 |
Synthesis and pharmacological characterization of 2-(4-chloro-3-hydroxyphenyl)ethylamine and N,N-dialkyl derivatives as dopamine receptor ligands. |
University of Camerino |
| 1354263 |
9 |
Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine. |
Universit£ |
| 1535660 |
14 |
Conformational analysis of dopamine D-2 receptor antagonists of the benzamide series in relation to a recently proposed D-2 receptor-interaction model. |
University of Lund |
| 1319493 |
31 |
Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 1680195 |
23 |
Dopamine autoreceptor agonists as potential antipsychotics. 3.6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine. |
Warner-Lambert |
| 1908521 |
106 |
Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. |
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer |
| 1648139 |
34 |
Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors. |
Virginia Commonwealth University |
| 1672158 |
40 |
Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners. |
Astra Research Centre |
| 1672156 |
81 |
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents. |
Hoechst-Roussel Pharmaceuticals |
| 1995885 |
15 |
Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds. |
Dainippon Pharmaceutical |
| 1833546 |
47 |
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. |
Abbott Laboratories |
| 1825115 |
16 |
Antidopaminergic effects of the stereoisomers of N-[(1-alkyl-2- pyrrolidinyl)methyl]-5-sulfamoylbenzamides and -2,3-dihydrobenzofuran-7-carboxamides. |
Yoshitomi Pharmaceutical Industries |
| 1671416 |
15 |
Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones. |
Warner-Lambert |
| 1671415 |
24 |
R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue. |
Northeastern University |
| 1975274 |
16 |
Synthesis and dopamine receptor affinities of 2-(4-fluoro-3- hydroxyphenyl)ethylamine and N-substituted derivatives. |
University of Camerino |
| 1971308 |
22 |
trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. |
Purdue University |
| 1969484 |
38 |
Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds. |
Astra Research Centre |
| 2172538 |
58 |
Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 1977907 |
33 |
(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
Abbott Laboratories |
| 2136919 |
33 |
Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain. |
Northeastern University |
| 1967314 |
35 |
4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties. |
Warner-Lambert |
| 2136916 |
26 |
Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents. |
University of Pennsylvania |
| 2547074 |
16 |
Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. |
National Institute of Digestive |
| 2569041 |
8 |
5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine. |
College of Pharmacy University of Iowa |
| 2542551 |
89 |
The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity. |
Bristol-Myers |
| 2565399 |
25 |
Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents. |
Wyeth-Ayerst Research |
| 2573732 |
84 |
Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. |
Eli Lilly |
| 2571729 |
15 |
Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties. |
University of G£Teborg |
| 3397992 |
73 |
Substituted benzamides. 1. Potential nondopaminergic antagonists of chemotherapy-induced nausea and emesis. |
Bristol-Myers |
| 2898533 |
50 |
Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies. |
Wyeth-Ayerst Research |
| 2966245 |
16 |
Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide. |
University of Pennsylvania |
| 2892932 |
8 |
Conformational analysis and structural comparisons of (1R,3S)-(+)- and (1S,3R)-(-)-tefludazine, (S)-(+)- and (R)-(-)-octoclothepin, and (+)-dexclamol in relation to dopamine receptor antagonism and amine-uptake inhibition. |
University of Lund |
| 2903929 |
143 |
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity. |
H. Lundbeck |
| 2903247 |
9 |
Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
State University of Groningen |
| 3172140 |
14 |
(S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo- 2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors. |
Vanderbilt University |
| 3050089 |
24 |
Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands. |
University of North Carolina |
| 3039136 |
328 |
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships. |
TBA |
| 2824773 |
92 |
N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors. |
University of G£Teborg |
| 2889830 |
26 |
2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1. |
Duphar Research Laboratories |
| 2888899 |
34 |
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds. |
Istituto Superiore Di Sanit£ |
| 2888898 |
41 |
Antipsychotic activity of substituted gamma-carbolines. |
Wyeth Laboratories |
| 2874226 |
27 |
Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives. |
TBA |
| 2869146 |
72 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents. |
TBA |
| 3761308 |
8 |
Enantiomers of 3-(3,4-dihydroxyphenyl)- and 3-(3-hydroxyphenyl)-N-n-propylpiperidine: central pre- and postsynaptic dopaminergic effects and pharmacokinetics. |
TBA |
| 4040977 |
26 |
Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides. |
TBA |
| 6317860 |
7 |
Synthesis, resolution, absolute stereochemistry, and enantioselectivity of 3',4'-dihydroxynomifensine. |
TBA |
| 15109634 |
129 |
SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis. |
Eli Lilly |
| 11814775 |
35 |
New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template. |
Wyeth-Ayerst Research Laboratories |
| 11755351 |
24 |
Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands. |
Universidad De Alcal£ |
| 11354357 |
61 |
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. |
Abbott Laboratories |
| 10571163 |
14 |
A novel class of Na+ and Ca2+ channel dual blockers with highly potent anti-ischemic effects. |
Institute For Bio-Medical Research |
| 9871571 |
44 |
A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin- 3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors. |
Dainippon Pharmaceutical |
| | 24 |
Synthesis and pharmacological activity of a macrocyclic benzamide |
TBA |
| | 8 |
Synthesis and pharmacological characterization of A-80426: A putative novel antidepressant combining -2 antagonism with 5-HT uptake inhibition |
TBA |
| | 12 |
Dopamine autoreceptor agonists: computational studies, synthesis and biological investigations |
TBA |
| | 22 |
Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385 |
TBA |
| | 34 |
(5S)-3-aryl-5-(1-piperidinylmethyl)-2-oxazolidinones, a new class of potential neuroleptics with a high affinity for sigma receptors |
TBA |
| | 13 |
Novel 4,5,6,7-tetrahydrobenzothiazole dopamine agonists display very low stereoselectivity in their interaction with dopamine receptors. |
TBA |
| 14695828 |
107 |
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents. |
Universit£ |
| 22277589 |
72 |
Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation. |
Jagiellonian University Medical College |
| 22133459 |
56 |
New potent 5-HT(2A) receptor ligands containing an N'-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation. |
Universit£ |
| 22029386 |
156 |
New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage. |
Universidad Complutense De Madrid |
| 21550699 |
24 |
New 2-thioether-substituted apomorphines as potent and selective dopamine D2 receptor agonists. |
University of Tartu |
| 21440338 |
36 |
Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents. |
Universit£ |
| 21366332 |
60 |
1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis. |
Pfizer |
| 21055848 |
10 |
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. |
University of Catania |
| 20812727 |
157 |
Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. |
National Institute of Mental Health |
| 20605099 |
42 |
Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol. |
Wayne State University |
| 20481570 |
81 |
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. |
Universita Di Siena |
| 20347301 |
32 |
New 5-HT(1A) receptor ligands containing a N'-cyanoisonicotinamidine nucleus: synthesis and in vitro pharmacological evaluation. |
Universit£ |
| 20060623 |
30 |
Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity. |
Jagiellonian University Medical College |
| 19679379 |
33 |
Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives. |
Jagiellonian University Medical College |
| 19540762 |
3 |
Tetrahydroisoquinolines as dopaminergic ligands: 1-Butyl-7-chloro-6-hydroxy-tetrahydroisoquinoline, a new compound with antidepressant-like activity in mice. |
Universidad De Valencia |
| 19454369 |
32 |
N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists. |
University of Tartu |
| 19427222 |
44 |
Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. |
Wayne State University |
| 1431946 |
28 |
Displacement Activity of Bisbenzylisoquinoline Alkaloids at Striatal 3H-SCH 23390 and 3H-Raclopride Binding Sites |
TBA |
| 15801844 |
54 |
Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors. |
TBA |
| | 52 |
Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity. |
TBA |
| | 40 |
(Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists |
TBA |
| | 53 |
5-HT1A and 5-HT2A ligands with anxiolytic and antipanic-like properties |
TBA |
| | 12 |
The synthesis and evaluation of the major metabolites of mazapertine |
TBA |
| | 48 |
(E) and (Z)-3-Styrylpiperidines as sigma ligands |
TBA |
| | 33 |
1-(2-METHOXYPHENYL)-4-ALKYLPIPERAZINES: EFFECT OF THE N-4 SUBSTITUENT ON THE AFFINITY AND SELECTIVITY FOR DOPAMINE D4 RECEPTOR |
TBA |
| | 43 |
2-[4-(o-methoxyphenyl)piperazin-1-ylmethyl]-1,3-dioxoperhydroimidazo[1,5-a]pyridine as a new selective 5-HT1A receptor ligand |
TBA |
| | 5 |
Suppression of morphine and cocaine self-administration in rats by a mixed mu antagonist-kappa agonist (N-CBM-TAMO) and a long-acting selective D1 antagonist (AS-300) |
TBA |
| | 68 |
N-(2-pyrrolidinylmethyl)benzoxazine-8-carboxamides exhibiting high affinities for All of D2, 5-HT1 A, and 5-HT2 receptors |
TBA |
| | 25 |
Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic properties |
TBA |
| | 6 |
Novel HO-DPAT (hydroxy-2-dipropylaminotetralin) isomers: Stereoselective synthesis and receptor binding studies |
TBA |
| | 4 |
Enhancement of binding of quaternary ammonium derivatives of chlorpromaxine to dopamine D-2 receptors by the addition of a H-bonding group |
TBA |
| | 16 |
4-Aminomethyl chromans: dependence of serotonin and dopamine binding upon aromatic ring substitution |
TBA |
| | 18 |
4-Aryltetrahydropyridines as selective σ ligands |
TBA |
| | 1 |
Substituted Benzamides with Conformationally Restricted Side Chains. 3. Azabicyclo[x.y.0] derivatives as gastric prokinetic agents. |
TBA |
| | 34 |
Dopamine receptor binding properties of some 2,3,4,5-tetrahydro-1H-3-benzazepine-7-ols with non-aromatic substituents in the 5-position |
TBA |
| | 10 |
Synthesis and dopaminergic activity of the enantiomers of 6-methyl-4,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine (PD 128483). |
TBA |
| 19425598 |
61 |
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships. |
European Research Centre For Drug Discovery and Development (Natsyndrugs) |
| 19072656 |
110 |
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior. |
University of Siena |
| 19058967 |
14 |
Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines. |
Harvard Medical School |
| 19053758 |
42 |
Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model. |
Wayne State University |
| 18785726 |
30 |
Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile. |
University of Michigan |
| 18598015 |
53 |
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands. |
Università |
| 18585036 |
18 |
Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines. |
Harvard Medical School |
| 18410082 |
50 |
Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity. |
Wayne State University |
| 18313931 |
33 |
Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. |
University of Debrecen |
| 18289859 |
24 |
Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines. |
University of Debrecen |
| 10785418 |
10 |
Halogenated boldine derivatives with enhanced monoamine receptor selectivity. |
Universidad De Chile |
| 9644051 |
4 |
Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine. |
Universidad De Valencia |
| 17720494 |
34 |
Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. |
Gedeon Richter |
| 17543523 |
17 |
R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. |
Harvard Medical School |
| 17434731 |
51 |
Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors. |
Eli Lilly |
| 17328523 |
36 |
Novel sigma receptor ligands: synthesis and biological profile. |
University of Catania |
| 17321139 |
48 |
Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation. |
University of Montpellier |
| 17234422 |
118 |
Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor. |
Taisho Pharmaceutical |
| 17149874 |
110 |
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. |
Abbott Laboratories |
| 16451052 |
2 |
Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. |
Johann Wolfgang Goethe University |
| 16250661 |
13 |
11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors. |
University of Milano/Bicocca |
| 16107148 |
44 |
New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation. |
Università |
| 15801839 |
51 |
CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists. |
Friedrich-Alexander University |
| 15801833 |
35 |
Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands. |
Università |
| 15771414 |
36 |
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies. |
Università |
| 15341484 |
159 |
Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors. |
Merck |
| 15341483 |
110 |
Indolebutylamines as selective 5-HT(1A) agonists. |
Merck |
| 15267230 |
50 |
Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists. |
Uppsala University |
| 15084129 |
52 |
4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity. |
Università |
| 14684327 |
60 |
Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands. |
Wake Forest University School of Medicine |
| 14592497 |
12 |
Synthesis and affinity of a possible byproduct of electrophilic radiolabeling of [123I]IBZM. |
Yale University |
| 12954065 |
8 |
Orally active oxime derivatives of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one. Synthesis and pharmacological activity. |
University Center For Pharmacy |
| 12798330 |
63 |
N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists. |
National Institute On Drug Abuse-Intramural Research Program |
| 12668005 |
21 |
Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist. |
Universidad Complutense |
| 12482441 |
45 |
Development of a presynaptic 5-HT1A antagonist. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 12166939 |
6 |
(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 12161137 |
39 |
Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725. |
Friedrich-Alexander University |
| 12109911 |
47 |
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine. |
University Center For Pharmacy |
| 12014970 |
42 |
Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2A ligands for PET or SPECT brain imaging. |
Yale University |
| 11934576 |
85 |
Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands. |
Université |
| 11784148 |
81 |
Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. |
Pharmazeutisches Institut Der UniversitäT Freiburg |
| 11741489 |
45 |
Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans. |
Pharmacia |
| 11728188 |
53 |
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines. |
Università |
| 32247749 |
119 |
Chemical puzzles in the search for new, flexible derivatives of lurasidone as antipsychotic drugs. |
Cracow University of Technology |
| 11462981 |
184 |
New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
Universidad De Navarra |
| 11462978 |
16 |
Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel. |
Astrazeneca Pharmaceuticals |
| 11378358 |
254 |
Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. |
Columbia University College of Physicians and Surgeons |
| 11356115 |
108 |
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands. |
Wake Forest University School of Medicine |
| 11356113 |
18 |
Enantioselective syntheses of dopaminergic (R)- and (S)-benzyltetrahydroisoquinolines. |
Universidad De Valencia |
| 11327592 |
9 |
1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors. |
Wyeth-Ayerst Research |
| 11294383 |
16 |
Cis- and trans-N-benzyl-octahydrobenzo[g]quinolines. Adrenergic and dopaminergic activity studies. |
University of Crete |
| 11229779 |
11 |
New 5-HT1A receptor agonists possessing 1,4-benzoxazepine scaffold exhibit highly potent anti-ischemic effects. |
Suntory Biomedical Research |
| 30685525 |
34 |
Benzimidazolone-based selective ? |
University of Florida |
| 11020279 |
42 |
New substituted 1-(2,3-dihydrobenzo[1, 4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with alpha(2)-adrenoceptor antagonist activity. |
Centre De Recherche Pierre Fabre |
| 10978188 |
85 |
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. |
Cocensys |
| 27567078 |
3 |
Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile. |
University of British Columbia |
| 10937721 |
9 |
Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity. |
University of Tokyo |
| 27591013 |
44 |
Novel multifunctional dopamine D |
Wayne State University |
| 31518969 |
59 |
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems. |
University of Siena |
| 10498215 |
60 |
New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. |
Wyeth-Ayerst Research Laboratories |
| 10464021 |
59 |
N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents. |
Knoll Pharmaceuticals |
| 10395488 |
114 |
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines. |
Cocensys |
| 10377229 |
107 |
New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. |
University of GöTeborg |
| 31253535 |
115 |
Design, synthesis and molecular modelling of new bulky Fananserin derivatives with altered pharmacological profile as potential antidepressants. |
Cracow University of Technology |
| 10360740 |
35 |
N-substituted-3-arylpyrrolidines: potent and selective ligands at serotonin 1A receptor. |
Postech |
| 10354409 |
131 |
New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template. |
Wyeth-Ayerst Research Laboratories |
| 9986719 |
39 |
1-aryl-4-[(5-methoxy-1,2,3, 4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5. |
Università |
| 9986714 |
105 |
Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists. |
Recordati |
| 9888831 |
83 |
Synthesis and structure-activity relationships of a new model of arylpiperazines. 4. 1-[omega-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene) - 2, 5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2, 5-pyrrolidinediones: study of the steric requirements of the terminal amide fragment on 5-HT1A a |
Universidad Complutense |
| 9876110 |
58 |
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). |
Centro De InvestigacióN Grupo Ferrer |
| 9873601 |
45 |
New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. |
Wyeth-Ayerst Research Laboratory |
| 9873388 |
24 |
Synthesis of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)nicotinamides and their affinities for 5-HT3 and dopamine D2 receptors. |
Dainippon Pharmaceutical |
| 9871719 |
144 |
Serotonergic ergoline derivatives. |
Pharmacia & Upjohn |
| 9871673 |
79 |
New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates. |
Wyeth-Ayerst Research Laboratories |
| 9871564 |
60 |
1-[omega-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5- pyrrolidinediones as 5-HT1A receptor ligands: study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity. |
Universidad Complutense |
| 9871525 |
56 |
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors. |
R. W. Johnson Pharmaceutical Research Institute |
| 9836624 |
64 |
Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding. |
Virginia Commonwealth University |
| 9667967 |
65 |
Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists. |
Yamanouchi Pharmaceutical |
| 9572880 |
44 |
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand. |
University of Camerino |
| 9406603 |
49 |
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. |
University of Groningen |
| 9046348 |
45 |
[[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT1A receptor ligands. |
Università |
| 9022796 |
57 |
5-HT1A-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines. |
Solvay Pharma |
| 9003524 |
23 |
3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as dopamine D2 partial agonists and autoreceptor agonists. |
Division of Warner Lambert |
| 8941384 |
51 |
5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates. |
University of Groningen |
| 8893838 |
106 |
Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist. |
Universidad Complutense |
| 8809161 |
90 |
Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. |
H. Lundbeck |
| 31547945 |
88 |
Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives. |
Cracow University of Technology |
| 8765528 |
16 |
(+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs: novel dopamine D1 receptor antagonists. |
National Institutes of Health |
| 8759640 |
61 |
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships. |
Warner-Lambert |
| 8709107 |
99 |
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds. |
Yamanouchi Pharmaceutical |
| 8691438 |
48 |
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist. |
Pharmacia & Upjohn |
| 8667368 |
42 |
Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist. |
University of Camerino |
| 26555041 |
42 |
Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson's Disease. |
Wayne State University |
| 8568802 |
42 |
Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives. |
Glaxo Wellcome |
| 8568801 |
13 |
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. |
Pfizer |
| 8558529 |
195 |
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease. |
Hoechst-Roussel Pharmaceuticals |
| 8496920 |
14 |
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. |
Wyeth Research (Uk) |
| 8496917 |
72 |
Bridged gamma-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors. |
Scios Nova |
| 8487257 |
57 |
New indole derivatives as potent and selective serotonin uptake inhibitors. |
Centre De Recherches De Vitry-Alfortville |
| 8426363 |
134 |
Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site. |
Scios Nova |
| 8411003 |
12 |
A structure-activity study of four dopamine D-1 and D-2 receptor antagonists, representing the phenylindan, -indene, and -indole structural classes of compounds. |
University of Lund |
| 8410999 |
81 |
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
Eli Lilly |
| 8340910 |
32 |
(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
University of GöTeborg |
| 8289207 |
30 |
Mixed 5-HT1A/D-2 activity of a new model of arylpiperazines: 1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines. 1. Synthesis and structure-activity relationships. |
Università |
| 8246239 |
84 |
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. |
Solvay Duphar |
| 8230107 |
61 |
Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists. |
University of GöTeborg |
| 24211020 |
35 |
Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands. |
University of Maryland |
| 8151622 |
22 |
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors. |
H. Lundbeck |
| 8101877 |
80 |
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
University of LièGe |
| 8097537 |
91 |
Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives. |
Upjohn Laboratories |
| 8093734 |
11 |
Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. |
University of Pennsylvania |
| 23974015 |
44 |
2,3,9- and 2,3,11-trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands. |
Universidad De Valencia |
| 8021913 |
9 |
Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells. |
George Washington University Medical Center |
| 23886690 |
24 |
3,4-Dihydroxy- and 3,4-methylenedioxy- phenanthrene-type alkaloids with high selectivity for D2 dopamine receptor. |
Universidad De Valencia |
| 23792350 |
53 |
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
Universidade Federal Do Rio De Janeiro |
| 7932581 |
32 |
The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
Parke-Davis Pharmaceutical Research |
| 7932553 |
42 |
6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
GöTeborg University |
| 7914539 |
36 |
Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents. |
Burroughs Wellcome |
| 7914538 |
9 |
Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. |
Purdue University |
| 7914536 |
96 |
Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents. |
Hoechst-Roussel Pharmaceuticals |
| 7909336 |
27 |
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. |
R. W. Johnson Pharmaceutical Research Institute |
| 7901415 |
36 |
Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics. |
Scios Nova |
| 7861420 |
62 |
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability. |
Upjohn Laboratories |
| 7830274 |
22 |
Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands. |
Purdue University |
| 7783152 |
170 |
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
GöTeborg University |
| 7699710 |
84 |
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2. |
Università |
| 7658443 |
5 |
Computer-aided design and synthesis of 5-substituted tryptamines and their pharmacology at the 5-HT1D receptor: discovery of compounds with potential anti-migraine properties. |
Wellcome Research Laboratories |
| 7608904 |
2 |
Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H- benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy- 1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10- dihydro-1,2-dihydroxyanthracene as conformationally restricted analogs of beta-phenyldopamin |
Purdue University |
| 7473566 |
152 |
Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity. |
H. Lundbeck |
| 17870534 |
21 |
Two new phenylpiperazines with atypical antipsychotic potential. |
Institute For Biological Research |
| 17869521 |
15 |
Rational design, synthesis and evaluation of (6aR( *),11bS( *))-1-(4-fluorophenyl)-4-{7-[4-(4-fluorophenyl)-4-oxobutyl]1,2,3,4,6,6a,7,11b,12,12a(RS)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indol-2-yl}-butan-1-one as a potential neuroleptic agent. |
Central Drug Research Institute |
| 17300168 |
81 |
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities. |
Pierre Fabre Research Center |
| 10691686 |
51 |
Binding and preliminary evaluation of 5-hydroxy- and 10-hydroxy-2,3, 12,12a-tetrahydro-1H-[1]benzoxepino[2,3,4-ij]isoquinolines as dopamine receptor ligands. |
Universit£ |
| 10229633 |
130 |
Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT1A receptors. |
Pierre Fabre Research Center |
| 10052959 |
20 |
Tetrahydrobenzindoles: selective antagonists of the 5-HT7 receptor. |
Meiji Seika Kaisha |
| 10514291 |
51 |
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors. |
University of Bologna |
| 10425105 |
51 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes. |
University of Camerino |
| 10425088 |
101 |
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics. |
Universidad De Santiago |
| 9046349 |
87 |
New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation. |
Faes |
| 9240350 |
9 |
A novel series of 2,5-substituted tryptamine derivatives as vascular 5HT1B/1D receptor antagonists. |
Monash University |
| 8917649 |
60 |
Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
University of Camerino |
| 7914540 |
16 |
Synthesis and atypical antipsychotic profile of some 2-(2-piperidinoethyl)benzocycloalkanones as analogues of butyrophenone. |
University of Santiago De Compostela |
| 30383372 |
190 |
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics. |
Huazhong University of Science and Technology |
| 3950903 |
12 |
Troponoids. 7. Chemistry and dopamine agonist activity of ciladopa and related aralkyltroponylpiperazines. |
TBA |
| 3746815 |
15 |
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin. |
TBA |
| 3385732 |
12 |
Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
Northeastern University |
| 2968456 |
2 |
Preparation of 7-oxaaporphine derivatives and evaluation of their dopaminergic activity. |
Cns Line |
| 2902227 |
10 |
Serotonergic properties of spiroxatrine enantiomers. |
University of Arizona |
| 2902226 |
39 |
2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 2. |
Duphar Research Laboratories |
| 2900897 |
2 |
Substituted benzamides with conformationally restricted side chains. 2. Indolizidine derivatives as central dopamine receptor antagonists. |
Beecham Pharmaceuticals Research Division |
| 2894466 |
39 |
Atypical antipsychotic agents: patterns of activity in a series of 3-substituted 2-pyridinyl-1-piperazine derivatives. |
Bristol-Myers |
| 2892936 |
21 |
Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
Warner-Lambert |
| 2888897 |
20 |
1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents. |
Warner-Lambert/Parke-Davis Pharmaceutical Research |
| 2887659 |
3 |
Charged analogues of chlorpromazine as dopamine antagonists. |
TBA |
| 2884314 |
28 |
Psychotropic agents: synthesis and antipsychotic activity of substituted beta-carbolines. |
TBA |
| 2666667 |
30 |
Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl- 1H-3-benzazepin-7-ol. |
Schering-Plough |
| 2571732 |
26 |
Substituted 5-amino-4,5,6,7-tetrahydroindazoles as partial ergoline structures with dopaminergic activity. |
Eli Lilly |
| 2571728 |
21 |
Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
Vanderbilt University |
| 2565400 |
132 |
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. |
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide |
| 2522993 |
2 |
Synthesis and D2 dopaminergic activity of pyrrolidinium, tetrahydrothiophenium, and tetrahydrothiophene analogues of sulpiride. |
Ohio State University |
| 2405158 |
38 |
Aporphines as antagonists of dopamine D-1 receptors. |
Eli Lilly |
| 2391685 |
10 |
N-fluoroalkylated and N-alkylated analogues of the dopaminergic D-2 receptor antagonist raclopride. |
Washington University |
| 2147956 |
18 |
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist. |
Research Biochemicals |
| 1973734 |
16 |
Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study. |
Astra Research Centre |
| 1971309 |
31 |
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. |
Northeastern University |
| 1968512 |
18 |
Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model. |
University of Lund |
| 1967652 |
27 |
Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
Vanderbilt University |
| 1967318 |
8 |
Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
Warner-Lambert |
| 1827843 |
27 |
Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors. |
University of California |
| 1683407 |
32 |
Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 1676758 |
12 |
Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists. |
H. Lundbeck |
| 1676427 |
21 |
1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents. |
Pfizer |
| 1671414 |
10 |
Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds. |
Istituto Superiore Di Sanità |
| 1662725 |
48 |
Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands. |
Virginia Commonwealth University |
| 1656044 |
18 |
Synthesis and receptor binding of enantiomeric N-substituted cis-N-[2-(3,4-dichlorophenyl)ethyl]-2-(1-pyrrolidinyl)cyclohexylamines as high-affinity sigma receptor ligands. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 1652023 |
179 |
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
Abbott Laboratories |
| 29220177 |
31 |
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties. |
Universit£ |
| 1533424 |
20 |
Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue. |
Research Biochemicals |
| 1531364 |
42 |
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. |
University of Pennsylvania |
| 1433207 |
22 |
6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists. |
University of GöTeborg |
| 1359142 |
40 |
Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1-pyridylalkyl)indoles. A novel conformational model to explain structure-activity relationships. |
E. Merck Darmstadt |
| 1353116 |
10 |
3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia. |
Hoechst-Roussel Pharmaceuticals |
| 1348090 |
64 |
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles. |
H. Lundbeck |
| 1336054 |
63 |
Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles. |
H. Lundbeck |
| 1336053 |
86 |
Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles. |
H. Lundbeck |
| 1315869 |
231 |
(Aminoalkoxy)chromones. Selective sigma receptor ligands. |
Nova Pharmaceutical |
| 1310114 |
30 |
Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 27049670 |
47 |
Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. |
Max Planck Institute of Molecular Physiology |
| 27038849 |
21 |
Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies. |
Universiti Teknologi Mara (Uitm), Puncak Alam Campus |
| 26684482 |
20 |
Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase. |
North-West University |
| 26851737 |
36 |
One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies. |
University of Karachi |
| 26218629 |
26 |
Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). |
Oregon Health & Science University |
| 26364932 |
22 |
Structure and Inhibition of Microbiome ß-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. |
University of North Carolina At Chapel Hill |
| 26073618 |
12 |
Synthesis of benzimidazole derivatives as potent ß-glucuronidase inhibitors. |
Universiti Teknologi Mara (Uitm) |
| 25462625 |
58 |
Salicylanilide diethyl phosphates as cholinesterases inhibitors. |
Charles University In Prague |
| 9089668 |
95 |
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. |
Northwestern University |
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